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BIOA - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
UniProt: P12995 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10117
Length: 429 (415)
Sequences: 9665
Seq/Len: 23.29

BIOA
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
69_K 73_D 4.772 1.00
386_Q 419_R 4.542 1.00
232_R 236_D 4.374 1.00
36_E 44_R 4.001 1.00
191_M 230_R 3.987 1.00
342_Q 411_Q 3.83 1.00
94_K 325_A 3.483 1.00
331_D 334_Q 3.455 1.00
31_S 38_I 3.287 1.00
66_A 70_S 3.174 1.00
256_K 262_H 3.083 1.00
342_Q 407_P 2.997 1.00
406_L 409_Q 2.927 1.00
63_Q 329_S 2.909 1.00
335_Q 339_I 2.842 1.00
63_Q 322_A 2.737 1.00
338_D 407_P 2.663 1.00
322_A 325_A 2.587 1.00
346_Q 414_T 2.487 1.00
233_K 237_R 2.482 1.00
195_A 237_R 2.456 1.00
230_R 233_K 2.439 1.00
94_K 328_E 2.417 1.00
382_F 385_E 2.403 1.00
30_V 40_S 2.392 1.00
61_H 326_I 2.361 1.00
48_G 413_L 2.352 1.00
63_Q 326_I 2.338 1.00
341_V 345_E 2.266 1.00
209_I 243_I 2.25 1.00
388_V 416_A 2.184 1.00
36_E 409_Q 2.183 1.00
38_I 44_R 1.987 1.00
86_A 90_E 1.979 1.00
194_F 231_I 1.973 1.00
382_F 386_Q 1.959 1.00
210_I 231_I 1.945 1.00
68_M 319_A 1.941 1.00
93_R 97_A 1.932 1.00
412_R 416_A 1.93 1.00
346_Q 411_Q 1.924 1.00
94_K 321_N 1.923 1.00
30_V 74_A 1.92 1.00
105_C 290_R 1.917 1.00
91_L 320_A 1.914 1.00
346_Q 415_A 1.902 1.00
65_N 69_K 1.895 1.00
353_A 418_N 1.891 1.00
344_R 348_A 1.881 1.00
208_V 235_C 1.872 1.00
136_R 204_E 1.865 1.00
109_A 284_S 1.859 1.00
140_F 227_W 1.832 1.00
39_L 43_R 1.823 1.00
326_I 330_G 1.79 1.00
176_P 193_G 1.784 1.00
33_E 62_P 1.782 1.00
346_Q 349_P 1.776 1.00
43_R 387_G 1.755 1.00
68_M 72_I 1.754 1.00
92_C 108_L 1.726 1.00
290_R 294_E 1.725 1.00
386_Q 423_D 1.709 1.00
44_R 412_R 1.708 1.00
116_V 271_C 1.663 1.00
226_E 229_K 1.655 1.00
36_E 412_R 1.649 1.00
272_L 285_A 1.632 1.00
104_E 290_R 1.63 1.00
256_K 337_A 1.624 1.00
195_A 199_A 1.624 1.00
339_I 410_L 1.595 1.00
335_Q 338_D 1.588 1.00
192_V 195_A 1.561 1.00
29_V 37_L 1.558 1.00
66_A 69_K 1.556 1.00
70_S 74_A 1.543 1.00
90_E 321_N 1.539 1.00
198_M 240_I 1.538 1.00
277_T 283_L 1.53 1.00
94_K 97_A 1.528 1.00
123_A 243_I 1.526 1.00
334_Q 338_D 1.525 1.00
272_L 287_L 1.521 1.00
339_I 342_Q 1.511 1.00
39_L 45_L 1.507 1.00
119_A 271_C 1.496 1.00
322_A 326_I 1.485 1.00
232_R 242_L 1.483 1.00
244_A 260_C 1.477 1.00
67_A 322_A 1.475 1.00
276_L 283_L 1.458 1.00
382_F 423_D 1.454 1.00
232_R 235_C 1.449 1.00
62_P 66_A 1.446 1.00
244_A 265_I 1.446 1.00
31_S 74_A 1.438 1.00
35_C 409_Q 1.434 1.00
256_K 261_E 1.43 1.00
99_T 287_L 1.428 1.00
386_Q 420_A 1.427 1.00
383_F 390_I 1.426 1.00
35_C 404_I 1.412 1.00
154_V 172_N 1.411 1.00
339_I 407_P 1.407 0.99
353_A 422_Q 1.407 0.99
210_I 228_L 1.401 0.99
60_N 65_N 1.401 0.99
61_H 330_G 1.4 0.99
118_V 286_T 1.398 0.99
90_E 325_A 1.396 0.99
136_R 173_L 1.387 0.99
382_F 420_A 1.386 0.99
350_A 414_T 1.379 0.99
68_M 315_L 1.376 0.99
33_E 44_R 1.373 0.99
283_L 317_C 1.364 0.99
98_M 328_E 1.36 0.99
352_D 418_N 1.359 0.99
269_I 288_T 1.357 0.99
96_V 106_V 1.355 0.99
208_V 231_I 1.355 0.99
405_I 410_L 1.354 0.99
138_L 205_I 1.352 0.99
407_P 411_Q 1.35 0.99
196_R 200_A 1.349 0.99
226_E 263_A 1.347 0.99
231_I 242_L 1.342 0.99
195_A 230_R 1.339 0.99
120_M 137_F 1.33 0.99
33_E 60_N 1.329 0.99
105_C 294_E 1.321 0.99
134_R 239_G 1.32 0.99
321_N 325_A 1.317 0.99
106_V 287_L 1.311 0.99
192_V 196_R 1.308 0.99
346_Q 418_N 1.308 0.99
342_Q 346_Q 1.305 0.99
36_E 46_V 1.304 0.99
229_K 233_K 1.302 0.99
344_R 361_V 1.284 0.99
344_R 366_G 1.283 0.99
70_S 73_D 1.28 0.99
283_L 320_A 1.279 0.99
260_C 270_L 1.278 0.99
116_V 209_I 1.274 0.99
418_N 422_Q 1.272 0.99
69_K 72_I 1.262 0.99
57_H 326_I 1.257 0.99
97_A 328_E 1.249 0.99
241_L 292_V 1.247 0.99
266_A 289_T 1.243 0.98
257_L 261_E 1.238 0.98
325_A 329_S 1.236 0.98
139_T 174_F 1.224 0.98
383_F 388_V 1.221 0.98
386_Q 416_A 1.221 0.98
154_V 209_I 1.22 0.98
415_A 419_R 1.214 0.98
276_L 285_A 1.2 0.98
409_Q 412_R 1.188 0.98
141_R 176_P 1.182 0.98
30_V 42_G 1.18 0.98
65_N 72_I 1.174 0.98
195_A 238_E 1.174 0.98
191_M 234_I 1.172 0.98
65_N 73_D 1.165 0.97
137_F 207_A 1.161 0.97
383_F 420_A 1.159 0.97
345_E 349_P 1.159 0.97
175_A 197_L 1.156 0.97
411_Q 415_A 1.156 0.97
233_K 236_D 1.155 0.97
333_Q 336_V 1.154 0.97
263_A 362_L 1.147 0.97
252_G 333_Q 1.144 0.97
199_A 238_E 1.134 0.97
327_L 332_W 1.13 0.97
327_L 333_Q 1.128 0.97
281_M 316_A 1.124 0.97
108_L 317_C 1.123 0.97
255_G 261_E 1.118 0.96
269_I 286_T 1.111 0.96
383_F 416_A 1.11 0.96
113_S 151_A 1.101 0.96
412_R 415_A 1.096 0.96
262_H 362_L 1.093 0.96
64_L 319_A 1.089 0.96
348_A 351_R 1.085 0.96
109_A 286_T 1.077 0.95
153_S 169_L 1.068 0.95
388_V 413_L 1.062 0.95
234_I 238_E 1.06 0.95
195_A 233_K 1.06 0.95
198_M 205_I 1.059 0.95
229_K 264_E 1.056 0.95
195_A 234_I 1.055 0.95
91_L 321_N 1.053 0.95
278_G 323_S 1.051 0.94
98_M 257_L 1.05 0.94
120_M 154_V 1.049 0.94
115_A 271_C 1.047 0.94
113_S 148_T 1.045 0.94
408_Q 411_Q 1.04 0.94
251_F 327_L 1.039 0.94
57_H 323_S 1.037 0.94
337_A 341_V 1.036 0.94
35_C 46_V 1.036 0.94
258_F 272_L 1.035 0.94
126_Y 295_T 1.031 0.94
350_A 418_N 1.028 0.94
358_D 369_E 1.027 0.94
29_V 32_A 1.02 0.93
326_I 329_S 1.01 0.93
378_A 382_F 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a0gA40.9931000.319Contact Map0.581
3tfuA20.9861000.357Contact Map0.713
4e3qA40.9931000.398Contact Map0.786
3hmuA20.9861000.399Contact Map0.813
3i5tA20.99531000.413Contact Map0.75
3oksA40.9511000.421Contact Map0.737
4atqA120.94871000.424Contact Map0.724
2epjA10.93941000.424Contact Map0.697
4ffcA40.95571000.425Contact Map0.66
1sffA40.95341000.434Contact Map0.768

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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