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BIOB - Biotin synthase
UniProt: P12996 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10118
Length: 346 (313)
Sequences: 2956
Seq/Len: 9.44

BIOB
Paralog alert: 0.58 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: BIOB THIH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
114_E 141_R 4.243 1.00
158_P 171_Q 4.017 1.00
136_E 182_D 3.826 1.00
121_K 148_D 3.369 1.00
30_V 252_I 3.3 1.00
159_E 201_D 3.015 1.00
78_V 115_Q 2.939 1.00
77_E 80_Q 2.885 1.00
9_L 204_G 2.829 1.00
110_M 114_E 2.775 1.00
28_Q 32_R 2.561 1.00
219_V 254_M 2.528 1.00
207_L 253_M 2.528 1.00
178_E 217_E 2.52 1.00
171_Q 175_D 2.511 1.00
136_E 179_K 2.43 1.00
111_P 141_R 2.338 1.00
81_V 116_M 2.296 1.00
78_V 119_G 2.261 1.00
136_E 140_Q 2.212 1.00
83_E 86_R 2.208 1.00
157_S 201_D 2.167 1.00
115_Q 118_Q 2.137 1.00
82_L 119_G 2.095 1.00
159_E 204_G 2.077 1.00
199_V 242_D 2.058 1.00
15_L 249_V 2.038 1.00
13_T 200_K 2.029 1.00
291_L 294_P 1.887 1.00
26_E 252_I 1.861 1.00
258_Y 282_N 1.84 1.00
202_R 242_D 1.838 1.00
140_Q 144_N 1.831 1.00
9_L 207_L 1.829 1.00
154_L 205_L 1.792 1.00
119_G 122_A 1.775 1.00
7_W 252_I 1.773 1.00
88_A 93_S 1.752 1.00
28_Q 278_M 1.716 1.00
189_S 209_L 1.711 1.00
259_V 281_A 1.695 1.00
303_Q 307_K 1.672 1.00
56_D 66_Y 1.671 1.00
13_T 17_E 1.655 1.00
32_R 38_R 1.637 1.00
80_Q 83_E 1.634 1.00
114_E 118_Q 1.626 1.00
86_R 90_A 1.618 1.00
175_D 179_K 1.613 1.00
206_L 250_A 1.584 1.00
149_Y 186_K 1.558 1.00
143_A 185_I 1.537 1.00
13_T 203_A 1.524 1.00
16_F 249_V 1.506 1.00
87_K 90_A 1.505 1.00
141_R 144_N 1.503 1.00
86_R 123_M 1.476 1.00
85_A 120_V 1.475 1.00
82_L 86_R 1.468 1.00
288_C 294_P 1.458 1.00
12_V 253_M 1.452 1.00
270_E 307_K 1.444 1.00
302_L 306_R 1.442 1.00
140_Q 143_A 1.44 1.00
306_R 312_P 1.437 1.00
159_E 163_N 1.428 0.99
117_V 147_L 1.427 0.99
137_S 140_Q 1.42 0.99
261_L 276_C 1.418 0.99
143_A 183_A 1.416 0.99
9_L 200_K 1.414 0.99
9_L 203_A 1.367 0.99
172_E 175_D 1.363 0.99
240_A 272_T 1.362 0.99
83_E 87_K 1.357 0.99
18_K 26_E 1.357 0.99
118_Q 145_A 1.342 0.99
24_L 279_A 1.34 0.99
207_L 211_N 1.333 0.99
244_I 276_C 1.324 0.99
12_V 207_L 1.317 0.99
8_T 11_Q 1.312 0.99
12_V 203_A 1.291 0.99
159_E 198_T 1.283 0.99
139_A 183_A 1.268 0.99
7_W 12_V 1.267 0.99
178_E 182_D 1.264 0.98
23_L 245_R 1.262 0.98
198_T 201_D 1.253 0.98
39_Q 311_N 1.251 0.98
9_L 13_T 1.25 0.98
152_H 173_R 1.248 0.98
193_V 246_T 1.24 0.98
204_G 207_L 1.239 0.98
117_V 127_A 1.239 0.98
160_F 163_N 1.236 0.98
47_S 50_T 1.234 0.98
111_P 115_Q 1.229 0.98
114_E 145_A 1.228 0.98
179_K 182_D 1.228 0.98
169_T 172_E 1.221 0.98
202_R 246_T 1.219 0.98
193_V 243_F 1.209 0.98
239_D 242_D 1.208 0.98
118_Q 144_N 1.206 0.98
17_E 199_V 1.202 0.98
50_T 101_A 1.202 0.98
29_Q 33_Q 1.201 0.98
74_R 104_N 1.196 0.98
113_L 131_L 1.185 0.97
28_Q 31_H 1.182 0.97
136_E 183_A 1.175 0.97
6_R 215_P 1.172 0.97
94_T 314_Q 1.165 0.97
303_Q 306_R 1.158 0.97
170_Y 174_L 1.155 0.97
206_L 209_L 1.154 0.97
16_F 246_T 1.153 0.97
25_F 29_Q 1.149 0.97
158_P 162_G 1.148 0.97
134_L 142_L 1.143 0.97
299_D 303_Q 1.136 0.96
206_L 253_M 1.136 0.96
226_K 237_D 1.135 0.96
113_L 142_L 1.133 0.96
76_M 81_V 1.133 0.96
19_P 22_D 1.133 0.96
135_S 138_Q 1.131 0.96
21_L 24_L 1.125 0.96
300_K 303_Q 1.124 0.96
42_V 302_L 1.1 0.96
82_L 123_M 1.1 0.96
6_R 216_P 1.099 0.96
107_E 141_R 1.097 0.95
297_E 300_K 1.09 0.95
6_R 255_P 1.083 0.95
158_P 208_Q 1.079 0.95
58_K 164_I 1.076 0.95
12_V 249_V 1.07 0.95
247_I 276_C 1.052 0.94
47_S 73_E 1.049 0.94
44_T 93_S 1.047 0.94
178_E 212_L 1.036 0.93
203_A 249_V 1.026 0.93
52_A 72_A 1.02 0.93
262_S 265_R 1.015 0.92
14_E 17_E 1.009 0.92
140_Q 183_A 1.007 0.92
84_S 87_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1r30A20.99711000.421Contact Map0.7
3t7vA10.90751000.504Contact Map0.64
3iixA10.91621000.52Contact Map0.746
1oltA10.959599.80.803Contact Map0.472
2qgqA80.800699.70.82Contact Map0.687
4jc0A20.92299.70.822Contact Map0.603
1tv8A20.849799.70.826Contact Map0.641
3rfaA20.826699.60.838Contact Map0.444
3c8fA10.647499.60.843Contact Map0.539
2yx0A10.809299.50.846Contact Map0.525

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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