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BIOC - Malonyl-CoA O-methyltransferase BioC
UniProt: P12999 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10119
Length: 251 (247)
Sequences: 2412
Seq/Len: 9.77

BIOC
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: BIOC CMOA SMTA TAM TEHB UBIE UBIG YAFE YJHP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_H 66_Q 3.357 1.00
99_L 104_F 3.103 1.00
125_E 128_R 3.083 1.00
130_V 136_V 2.773 1.00
47_L 104_F 2.68 1.00
125_E 129_V 2.668 1.00
51_C 69_A 2.616 1.00
105_D 131_R 2.538 1.00
66_Q 88_H 2.514 1.00
77_L 91_A 2.36 1.00
109_S 112_A 2.293 1.00
74_P 78_V 2.287 1.00
48_D 69_A 2.248 1.00
68_T 104_F 2.157 1.00
193_D 196_S 2.089 1.00
21_E 53_P 2.078 1.00
130_V 134_G 2.042 1.00
126_L 136_V 2.016 1.00
70_L 92_G 2.011 1.00
107_A 126_L 2.005 1.00
45_H 68_T 1.926 1.00
77_L 89_Y 1.905 1.00
69_A 89_Y 1.899 1.00
177_G 180_Y 1.849 1.00
107_A 130_V 1.753 1.00
118_N 121_T 1.75 1.00
50_G 112_A 1.74 1.00
46_V 106_L 1.736 1.00
49_A 94_I 1.717 1.00
49_A 126_L 1.701 1.00
138_F 246_G 1.695 1.00
94_I 116_C 1.657 1.00
29_Q 33_A 1.64 1.00
219_T 222_Q 1.623 1.00
110_N 139_T 1.601 1.00
175_L 248_I 1.598 1.00
95_E 116_C 1.574 1.00
114_Q 206_A 1.536 1.00
101_T 128_R 1.519 1.00
8_A 12_A 1.518 1.00
141_L 145_S 1.5 1.00
34_L 137_A 1.467 1.00
31_A 56_M 1.463 1.00
195_L 227_Q 1.46 1.00
80_A 89_Y 1.444 1.00
225_R 228_L 1.431 1.00
142_V 244_F 1.422 1.00
74_P 91_A 1.421 1.00
6_K 93_D 1.418 1.00
33_A 185_Q 1.41 0.99
101_T 125_E 1.387 0.99
111_L 141_L 1.369 0.99
127_Y 250_R 1.354 0.99
68_T 90_L 1.353 0.99
30_S 110_N 1.352 0.99
220_R 224_Q 1.351 0.99
97_L 129_V 1.349 0.99
27_Q 115_W 1.347 0.99
51_C 80_A 1.341 0.99
23_H 203_G 1.337 0.99
186_P 242_H 1.33 0.99
6_K 95_E 1.328 0.99
97_L 125_E 1.323 0.99
58_R 83_K 1.309 0.99
71_D 77_L 1.299 0.99
71_D 76_M 1.293 0.99
30_S 111_L 1.286 0.99
98_P 125_E 1.276 0.99
14_G 73_S 1.261 0.99
70_L 90_L 1.247 0.98
119_L 171_I 1.241 0.98
47_L 107_A 1.241 0.98
45_H 131_R 1.24 0.98
218_L 222_Q 1.237 0.98
78_V 82_Q 1.231 0.98
57_S 89_Y 1.228 0.98
50_G 115_W 1.223 0.98
95_E 117_G 1.221 0.98
14_G 75_P 1.216 0.98
43_Y 65_A 1.211 0.98
172_E 176_N 1.205 0.98
95_E 112_A 1.202 0.98
192_D 196_S 1.193 0.98
48_D 54_G 1.171 0.97
30_S 243_L 1.171 0.97
92_G 98_P 1.168 0.97
148_E 240_T 1.168 0.97
33_A 37_M 1.158 0.97
57_S 69_A 1.147 0.97
127_Y 178_V 1.147 0.97
14_G 17_A 1.146 0.97
101_T 129_V 1.141 0.97
104_F 107_A 1.14 0.97
37_M 183_H 1.139 0.97
100_A 103_T 1.139 0.97
79_Q 82_Q 1.137 0.97
228_L 232_Q 1.134 0.97
33_A 245_L 1.121 0.96
116_C 122_A 1.113 0.96
71_D 93_D 1.11 0.96
20_Y 27_Q 1.11 0.96
202_K 205_G 1.101 0.96
107_A 129_V 1.1 0.96
167_P 170_E 1.096 0.96
191_F 200_S 1.09 0.96
137_A 247_V 1.088 0.95
179_H 249_A 1.077 0.95
48_D 52_G 1.075 0.95
24_A 27_Q 1.061 0.95
139_T 243_L 1.055 0.94
94_I 112_A 1.049 0.94
48_D 67_V 1.045 0.94
50_G 109_S 1.035 0.94
48_D 70_L 1.026 0.93
111_L 114_Q 1.022 0.93
221_S 225_R 1.02 0.93
13_F 20_Y 1.019 0.93
185_Q 245_L 1.018 0.93
51_C 71_D 1.016 0.93
44_T 65_A 1.004 0.92
200_S 204_I 1.004 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2p35A20.94021000.384Contact Map0.654
3ccfA20.97211000.402Contact Map0.732
2yqzA20.94421000.421Contact Map0.719
4hg2A20.95221000.441Contact Map0.634
4fsdA10.96411000.444Contact Map0.65
1vl5A40.94021000.448Contact Map0.797
3busA20.96411000.459Contact Map0.728
3egeA10.92431000.46Contact Map0.689
1xxlA20.90041000.469Contact Map0.744
2o57A40.94821000.471Contact Map0.772

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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