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BIOD1 - ATP-dependent dethiobiotin synthetase BioD 1
UniProt: P13000 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10120
Length: 225 (223)
Sequences: 1355
Seq/Len: 6.08

BIOD1
Paralog alert: 0.29 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: BIOD1 BIOD2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
144_L 159_T 3.862 1.00
161_Q 166_A 2.911 1.00
142_V 163_I 2.597 1.00
146_V 152_C 2.491 1.00
160_A 170_L 2.44 1.00
19_A 174_V 2.367 1.00
78_A 90_E 2.33 1.00
11_D 155_H 2.146 1.00
79_E 89_Q 2.141 1.00
154_N 158_L 2.118 1.00
161_Q 165_H 2.029 1.00
27_A 112_W 2.019 1.00
77_F 92_R 1.963 1.00
88_A 127_D 1.956 1.00
147_G 152_C 1.912 1.00
5_Y 171_A 1.874 1.00
95_E 98_V 1.833 1.00
5_Y 143_I 1.824 1.00
79_E 90_E 1.799 1.00
33_R 111_D 1.784 1.00
146_V 156_A 1.764 1.00
148_V 175_A 1.761 1.00
24_L 34_T 1.757 1.00
153_I 192_L 1.75 1.00
47_T 50_G 1.717 1.00
37_Y 102_G 1.712 1.00
126_S 129_F 1.71 1.00
121_W 163_I 1.65 1.00
152_C 156_A 1.626 1.00
136_T 166_A 1.59 0.99
8_T 117_G 1.573 0.99
147_G 155_H 1.551 0.99
142_V 168_L 1.541 0.99
20_S 114_L 1.504 0.99
44_S 76_T 1.49 0.99
134_W 138_E 1.48 0.99
132_A 166_A 1.477 0.99
37_Y 103_L 1.452 0.99
160_A 196_I 1.44 0.99
10_T 152_C 1.42 0.98
11_D 147_G 1.411 0.98
163_I 168_L 1.406 0.98
7_V 20_S 1.401 0.98
68_D 71_T 1.384 0.98
28_K 34_T 1.359 0.98
36_G 59_L 1.329 0.97
24_L 114_L 1.317 0.97
11_D 149_K 1.302 0.97
8_T 159_T 1.299 0.97
59_L 62_N 1.293 0.97
146_V 175_A 1.291 0.97
122_F 162_V 1.289 0.97
100_S 138_E 1.288 0.97
148_V 152_C 1.288 0.97
11_D 74_P 1.286 0.97
6_F 117_G 1.271 0.96
36_G 63_S 1.26 0.96
213_N 216_T 1.259 0.96
74_P 102_G 1.251 0.96
173_W 196_I 1.234 0.95
153_I 175_A 1.228 0.95
154_N 159_T 1.228 0.95
46_K 78_A 1.22 0.95
85_I 187_E 1.216 0.95
161_Q 164_Q 1.209 0.95
130_T 195_M 1.199 0.94
115_V 141_P 1.194 0.94
77_F 93_P 1.19 0.94
159_T 162_V 1.187 0.94
73_N 76_T 1.175 0.94
192_L 196_I 1.172 0.94
42_S 77_F 1.169 0.93
19_A 204_I 1.165 0.93
115_V 140_L 1.153 0.93
71_T 109_Q 1.151 0.93
55_D 61_R 1.15 0.93
82_S 85_I 1.141 0.92
149_K 152_C 1.134 0.92
157_M 195_M 1.134 0.92
40_V 125_L 1.131 0.92
145_V 176_N 1.13 0.92
96_S 129_F 1.117 0.91
42_S 81_T 1.116 0.91
4_R 140_L 1.111 0.91
122_F 132_A 1.107 0.91
24_L 36_G 1.1 0.90
163_I 170_L 1.083 0.89
198_A 201_L 1.08 0.89
175_A 200_L 1.076 0.89
19_A 176_N 1.074 0.89
135_V 168_L 1.069 0.89
27_A 34_T 1.068 0.89
212_E 216_T 1.068 0.89
22_A 202_G 1.059 0.88
37_Y 74_P 1.05 0.87
122_F 161_Q 1.049 0.87
121_W 159_T 1.049 0.87
193_T 200_L 1.048 0.87
144_L 170_L 1.047 0.87
221_N 224_L 1.036 0.86
40_V 99_M 1.03 0.86
121_W 135_V 1.03 0.86
160_A 164_Q 1.026 0.86
162_V 166_A 1.026 0.86
81_T 188_Y 1.025 0.86
215_A 218_K 1.023 0.86
187_E 190_T 1.019 0.85
104_R 107_E 1.019 0.85
122_F 166_A 1.014 0.85
211_P 214_A 1.01 0.85
75_Y 98_V 1.007 0.84
81_T 84_H 1.005 0.84
47_T 52_R 1.003 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a0gA40.97331000.329Contact Map0.627
2obnA40.81000.53Contact Map0.424
3fgnA40.95561000.568Contact Map0.738
3of5A20.96441000.604Contact Map0.717
1byiA10.99111000.607Contact Map0.7
3zq6A40.991199.90.62Contact Map0.588
3qxcA10.946799.90.633Contact Map0.68
1s1mA20.991199.90.635Contact Map0.41
3ug7A40.991199.90.644Contact Map0.545
2g0tA20.6899.90.661Contact Map0.513

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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