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BIOH - Pimelyl-[acyl-carrier protein] methyl ester esterase
UniProt: P13001 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10122
Length: 256 (253)
Sequences: 23425
Seq/Len: 92.59

BIOH
Paralog alert: 0.80 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: BIOH DLHH MENH MHPC PLDB RUTD YBFF YCJY YFHR YGHX YJFP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_I 101_A 4.335 1.00
8_T 41_T 4.087 1.00
48_P 67_A 3.704 1.00
32_I 246_C 3.274 1.00
205_Y 231_A 3.104 1.00
200_L 252_L 2.914 1.00
241_H 244_E 2.887 1.00
75_K 100_Q 2.711 1.00
228_Y 248_L 2.677 1.00
105_V 245_F 2.544 1.00
77_I 100_Q 2.518 1.00
69_L 91_I 2.275 1.00
106_A 207_D 2.253 1.00
230_F 248_L 2.247 1.00
39_H 250_V 2.234 1.00
91_I 95_H 2.184 1.00
205_Y 229_I 2.18 1.00
219_D 225_S 2.116 1.00
66_E 94_T 2.005 1.00
226_E 255_R 2 1.00
78_W 88_A 1.993 1.00
85_G 107_S 1.983 1.00
199_F 222_W 1.938 1.00
90_Q 94_T 1.924 1.00
233_A 241_H 1.911 1.00
92_A 102_L 1.888 1.00
69_L 95_H 1.876 1.00
103_V 249_L 1.837 1.00
35_E 246_C 1.827 1.00
212_R 229_I 1.82 1.00
15_H 43_H 1.816 1.00
77_I 103_V 1.808 1.00
3_N 54_R 1.787 1.00
19_L 47_L 1.744 1.00
15_H 41_T 1.74 1.00
88_A 102_L 1.736 1.00
7_Q 26_A 1.725 1.00
248_L 251_A 1.706 1.00
77_I 253_K 1.705 1.00
5_W 52_R 1.69 1.00
23_G 82_S 1.681 1.00
69_L 98_R 1.676 1.00
72_A 76_A 1.642 1.00
18_L 79_L 1.613 1.00
33_D 44_L 1.604 1.00
217_M 221_L 1.592 1.00
45_V 68_V 1.579 1.00
247_H 251_A 1.577 1.00
26_A 52_R 1.551 1.00
244_E 248_L 1.542 1.00
62_A 94_T 1.535 1.00
19_L 88_A 1.534 1.00
104_T 107_S 1.531 1.00
230_F 233_A 1.528 1.00
191_P 194_N 1.521 1.00
47_L 87_V 1.52 1.00
68_V 91_I 1.517 1.00
73_P 98_R 1.503 1.00
8_T 43_H 1.5 1.00
18_L 42_L 1.485 1.00
20_H 50_F 1.482 1.00
24_L 28_V 1.48 1.00
65_A 90_Q 1.452 1.00
5_W 26_A 1.442 1.00
19_L 68_V 1.439 1.00
91_I 99_V 1.423 1.00
35_E 250_V 1.412 1.00
200_L 228_Y 1.39 0.99
9_K 44_L 1.388 0.99
14_V 77_I 1.378 0.99
90_Q 93_L 1.377 0.99
95_H 98_R 1.375 0.99
6_W 71_Q 1.362 0.99
43_H 71_Q 1.353 0.99
26_A 46_D 1.341 0.99
216_P 220_K 1.338 0.99
103_V 200_L 1.326 0.99
245_F 249_L 1.32 0.99
81_W 238_F 1.316 0.99
244_E 247_H 1.316 0.99
40_F 77_I 1.312 0.99
4_I 53_S 1.311 0.99
20_H 47_L 1.294 0.99
222_W 225_S 1.291 0.99
102_L 199_F 1.289 0.99
60_S 63_D 1.288 0.99
203_Y 215_V 1.284 0.99
202_L 248_L 1.28 0.99
89_S 104_T 1.269 0.99
233_A 237_P 1.264 0.99
91_I 98_R 1.255 0.99
233_A 240_S 1.249 0.99
193_Q 221_L 1.241 0.98
26_A 44_L 1.23 0.98
35_E 243_A 1.217 0.98
35_E 38_S 1.195 0.98
65_A 87_V 1.184 0.98
79_L 105_V 1.175 0.98
46_D 51_G 1.174 0.98
40_F 254_Q 1.173 0.98
205_Y 232_K 1.17 0.97
93_L 191_P 1.164 0.97
212_R 216_P 1.164 0.97
14_V 100_Q 1.163 0.97
216_P 227_S 1.15 0.97
202_L 230_F 1.149 0.97
79_L 249_L 1.145 0.97
234_A 240_S 1.125 0.97
23_G 50_F 1.12 0.96
243_A 247_H 1.106 0.96
21_G 82_S 1.103 0.96
17_V 76_A 1.098 0.96
103_V 253_K 1.09 0.96
203_Y 229_I 1.088 0.96
16_L 40_F 1.083 0.96
16_L 79_L 1.08 0.95
216_P 229_I 1.069 0.95
219_D 227_S 1.066 0.95
17_V 68_V 1.066 0.95
40_F 253_K 1.066 0.95
226_E 248_L 1.064 0.95
79_L 103_V 1.062 0.95
78_W 91_I 1.045 0.94
203_Y 212_R 1.044 0.94
216_P 219_D 1.044 0.94
76_A 99_V 1.042 0.94
217_M 220_K 1.039 0.94
69_L 94_T 1.034 0.94
200_L 226_E 1.034 0.94
28_V 238_F 1.029 0.94
37_S 42_L 1.024 0.93
39_H 254_Q 1.024 0.93
228_Y 244_E 1.022 0.93
101_A 198_P 1.016 0.93
230_F 244_E 1.012 0.93
101_A 252_L 1.01 0.93
215_V 227_S 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1m33A111000.042Contact Map0.795
3om8A20.96481000.115Contact Map0.779
1womA20.98441000.119Contact Map0.741
1ehyA40.97661000.12Contact Map0.799
2xuaA20.96481000.127Contact Map0.858
2pujA10.98441000.134Contact Map0.819
3oosA10.98051000.135Contact Map0.73
3hssA20.98051000.143Contact Map0.783
2xmzA10.97271000.149Contact Map0.762
3bf7A20.96091000.153Contact Map0.76

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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