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PROV - Glycine betaine/L-proline transport ATP-binding protein ProV
UniProt: P14175 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10771
Length: 400 (391)
Sequences: 1124
Seq/Len: 2.87

PROV
Paralog alert: 0.38 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
247_G 251_E 4.423 1.00
8_K 84_Q 4.315 1.00
74_L 219_V 4.09 1.00
6_E 50_A 4.044 1.00
9_N 46_D 3.922 1.00
150_R 155_E 3.625 1.00
84_Q 91_D 3.501 1.00
45_K 242_E 3.409 1.00
96_S 99_E 2.971 1.00
76_R 79_E 2.897 1.00
71_V 221_I 2.886 1.00
137_N 140_E 2.673 1.00
259_D 262_R 2.652 1.00
146_L 158_A 2.542 1.00
91_D 94_K 2.528 1.00
315_E 319_K 2.505 1.00
206_E 209_K 2.426 1.00
44_V 47_A 2.41 1.00
49_L 246_V 2.395 1.00
244_V 258_N 2.384 1.00
124_L 146_L 2.359 1.00
55_E 234_R 2.331 1.00
374_D 378_Q 2.283 1.00
143_E 147_D 2.259 1.00
90_V 99_E 2.256 1.00
29_L 37_K 2.239 1.00
59_I 221_I 2.164 1.00
6_E 86_L 2.145 1.00
205_D 230_R 2.077 1.00
4_K 88_D 2.062 1.00
47_A 243_V 2.024 1.00
5_L 219_V 1.988 1.00
51_I 219_V 1.975 1.00
136_I 140_E 1.953 0.99
276_A 359_L 1.934 0.99
124_L 159_H 1.896 0.99
144_K 147_D 1.814 0.99
10_L 85_V 1.737 0.98
239_Q 258_N 1.727 0.98
62_L 65_S 1.725 0.98
107_K 184_D 1.716 0.98
88_D 107_K 1.7 0.98
102_E 106_K 1.699 0.98
18_P 40_L 1.663 0.98
138_A 142_R 1.66 0.98
122_T 161_Y 1.617 0.97
90_V 107_K 1.609 0.97
106_K 134_A 1.6 0.97
23_K 27_Q 1.591 0.97
236_A 243_V 1.59 0.97
33_Q 37_K 1.565 0.97
90_V 95_I 1.546 0.96
5_L 87_I 1.536 0.96
118_M 121_M 1.52 0.96
30_S 33_Q 1.51 0.95
125_D 128_A 1.505 0.95
132_E 141_R 1.504 0.95
205_D 252_I 1.498 0.95
128_A 142_R 1.472 0.95
121_M 132_E 1.466 0.94
57_F 246_V 1.456 0.94
4_K 53_E 1.439 0.94
149_L 158_A 1.436 0.94
141_R 145_A 1.431 0.93
140_E 143_E 1.423 0.93
124_L 145_A 1.41 0.93
75_N 188_M 1.407 0.93
24_Y 29_L 1.399 0.92
52_E 55_E 1.391 0.92
130_G 175_L 1.381 0.92
56_I 208_V 1.349 0.91
53_E 215_Q 1.336 0.90
7_I 10_L 1.334 0.90
277_K 352_A 1.331 0.90
5_L 103_V 1.33 0.90
116_A 127_T 1.324 0.89
122_T 125_D 1.322 0.89
109_A 183_P 1.321 0.89
56_I 207_L 1.314 0.89
8_K 86_L 1.314 0.89
153_G 173_V 1.3 0.88
101_R 108_I 1.297 0.88
186_L 232_G 1.293 0.88
6_E 89_G 1.289 0.88
125_D 142_R 1.288 0.88
324_V 342_A 1.288 0.88
47_A 238_M 1.287 0.88
151_Q 213_K 1.286 0.88
209_K 213_K 1.284 0.87
26_E 82_R 1.281 0.87
5_L 185_I 1.278 0.87
34_I 38_T 1.277 0.87
142_R 146_L 1.277 0.87
350_V 370_V 1.274 0.87
259_D 263_T 1.27 0.87
139_E 143_E 1.258 0.86
234_R 246_V 1.247 0.85
175_L 232_G 1.245 0.85
8_K 50_A 1.244 0.85
120_H 222_S 1.236 0.85
193_S 276_A 1.214 0.83
34_I 42_L 1.214 0.83
207_L 218_I 1.206 0.83
130_G 181_I 1.195 0.82
29_L 33_Q 1.195 0.82
7_I 49_L 1.192 0.82
124_L 142_R 1.162 0.79
29_L 34_I 1.159 0.79
50_A 137_N 1.156 0.79
186_L 207_L 1.154 0.79
65_S 70_M 1.143 0.78
354_T 358_E 1.139 0.77
7_I 51_I 1.132 0.77
53_E 88_D 1.131 0.77
178_A 188_M 1.127 0.76
161_Y 164_E 1.124 0.76
324_V 329_L 1.124 0.76
101_R 105_R 1.116 0.75
47_A 148_A 1.116 0.75
384_S 387_M 1.1 0.74
9_N 48_S 1.099 0.74
143_E 150_R 1.094 0.73
85_V 95_I 1.093 0.73
75_N 187_L 1.088 0.73
72_R 77_L 1.088 0.73
95_I 103_V 1.079 0.72
178_A 187_L 1.07 0.71
371_P 385_K 1.063 0.70
237_I 252_I 1.062 0.70
57_F 234_R 1.062 0.70
24_Y 34_I 1.06 0.70
65_S 72_R 1.06 0.70
352_A 380_V 1.058 0.70
355_P 358_E 1.057 0.70
146_L 150_R 1.056 0.69
7_I 74_L 1.056 0.69
134_A 216_R 1.055 0.69
349_A 371_P 1.055 0.69
78_I 233_D 1.052 0.69
235_I 248_T 1.052 0.69
17_H 20_R 1.046 0.68
108_I 133_L 1.046 0.68
52_E 234_R 1.044 0.68
119_P 235_I 1.04 0.68
95_I 99_E 1.04 0.68
160_S 164_E 1.039 0.68
57_F 236_A 1.038 0.68
60_M 203_M 1.038 0.68
31_K 157_Y 1.035 0.67
183_P 206_E 1.032 0.67
44_V 73_L 1.032 0.67
136_I 144_K 1.031 0.67
350_V 359_L 1.03 0.67
157_Y 169_M 1.03 0.67
87_I 103_V 1.029 0.67
21_A 40_L 1.029 0.67
73_L 148_A 1.027 0.66
239_Q 270_I 1.023 0.66
76_R 175_L 1.02 0.66
173_V 176_A 1.018 0.65
75_N 178_A 1.015 0.65
124_L 127_T 1.015 0.65
58_V 220_F 1.014 0.65
147_D 150_R 1.009 0.64
191_A 203_M 1.002 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1oxxK10.851000.516Contact Map0.571
2it1A20.86251000.517Contact Map0.672
1v43A10.85251000.52Contact Map0.629
1g29120.8751000.524Contact Map0.659
2yyzA10.83751000.527Contact Map0.621
3rlfA20.83251000.527Contact Map0.623
3fvqA20.881000.53Contact Map0.546
3tuiC40.8351000.534Contact Map0.747
3d31A20.8451000.536Contact Map0.609
1z47A20.8551000.537Contact Map0.675

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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