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ZRAS - Sensor protein ZraS
UniProt: P14377 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10008
Length: 465 (435)
Sequences: 2168
Seq/Len: 4.98

ZRAS
Paralog alert: 0.57 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
394_T 449_T 3.991 1.00
372_I 376_G 3.919 1.00
436_G 454_L 3.916 1.00
440_V 450_F 3.713 1.00
395_D 399_G 3.588 1.00
409_F 438_I 3.374 1.00
405_L 442_S 3.165 1.00
97_D 101_I 3.126 1.00
372_I 396_S 2.947 1.00
431_V 436_G 2.84 1.00
431_V 452_L 2.835 1.00
342_T 381_T 2.676 1.00
321_I 361_L 2.619 1.00
352_A 357_L 2.521 1.00
407_A 410_T 2.496 1.00
324_S 365_Y 2.392 1.00
408_I 440_V 2.385 1.00
376_G 396_S 2.383 1.00
442_S 448_S 2.344 1.00
315_V 357_L 2.33 1.00
428_H 432_E 2.311 1.00
427_V 438_I 2.308 1.00
431_V 438_I 2.304 1.00
364_L 393_V 2.246 1.00
381_T 394_T 2.22 1.00
395_D 447_G 2.212 1.00
340_R 379_S 2.194 1.00
431_V 454_L 2.188 1.00
316_D 319_T 2.149 1.00
441_A 451_T 2.128 1.00
314_A 349_E 2.105 1.00
350_I 389_V 2.08 1.00
443_Q 446_K 2.062 1.00
401_A 404_Q 2.048 1.00
392_S 449_T 2.035 1.00
360_V 430_I 2.024 1.00
400_I 408_I 1.986 1.00
392_S 451_T 1.973 1.00
267_A 287_M 1.972 1.00
404_Q 413_F 1.953 1.00
441_A 449_T 1.95 1.00
338_Q 377_V 1.937 1.00
360_V 452_L 1.922 1.00
371_A 414_T 1.874 1.00
409_F 450_F 1.872 1.00
379_S 394_T 1.862 1.00
360_V 431_V 1.861 1.00
361_L 393_V 1.824 1.00
408_I 450_F 1.807 1.00
264_K 292_D 1.771 1.00
321_I 380_V 1.751 1.00
10_S 14_W 1.749 1.00
388_G 453_W 1.743 1.00
340_R 377_V 1.728 1.00
381_T 392_S 1.725 1.00
405_L 440_V 1.716 1.00
440_V 448_S 1.701 1.00
251_G 411_P 1.685 0.99
372_I 378_I 1.667 0.99
436_G 455_P 1.644 0.99
322_N 341_F 1.634 0.99
332_A 369_I 1.634 0.99
315_V 352_A 1.603 0.99
422_L 426_V 1.576 0.99
352_A 434_H 1.575 0.99
439_Q 451_T 1.572 0.99
400_I 404_Q 1.562 0.99
409_F 428_H 1.561 0.99
383_S 390_K 1.56 0.99
438_I 450_F 1.552 0.99
323_H 354_P 1.531 0.99
389_V 456_V 1.509 0.99
325_L 380_V 1.508 0.99
385_S 390_K 1.501 0.98
390_K 453_W 1.484 0.98
313_Q 354_P 1.482 0.98
245_L 249_A 1.478 0.98
342_T 379_S 1.476 0.98
404_Q 415_T 1.459 0.98
400_I 448_S 1.456 0.98
442_S 445_G 1.455 0.98
321_I 391_I 1.451 0.98
46_R 144_L 1.45 0.98
218_S 222_Y 1.45 0.98
411_P 414_T 1.446 0.98
437_T 453_W 1.443 0.98
384_E 456_V 1.44 0.98
95_V 181_I 1.438 0.98
361_L 452_L 1.437 0.98
399_G 447_G 1.423 0.98
409_F 440_V 1.406 0.97
100_G 103_I 1.398 0.97
361_L 391_I 1.386 0.97
379_S 396_S 1.366 0.97
271_A 288_A 1.364 0.97
295_N 299_S 1.36 0.97
337_I 372_I 1.35 0.97
310_L 353_D 1.346 0.96
390_K 451_T 1.328 0.96
332_A 339_L 1.321 0.96
321_I 382_A 1.321 0.96
405_L 441_A 1.317 0.96
348_P 382_A 1.314 0.96
394_T 443_Q 1.314 0.96
256_I 294_L 1.304 0.96
388_G 437_T 1.3 0.95
256_I 298_V 1.296 0.95
377_V 396_S 1.291 0.95
366_L 370_Q 1.291 0.95
317_L 389_V 1.286 0.95
276_A 279_E 1.283 0.95
264_K 288_A 1.271 0.95
314_A 351_Q 1.258 0.94
395_D 448_S 1.25 0.94
363_N 427_V 1.247 0.94
247_H 251_G 1.242 0.94
325_L 339_L 1.237 0.94
361_L 365_Y 1.223 0.93
419_G 447_G 1.223 0.93
260_L 298_V 1.222 0.93
321_I 341_F 1.214 0.93
240_E 243_V 1.201 0.92
328_V 366_L 1.194 0.92
236_M 246_G 1.186 0.92
400_I 409_F 1.169 0.91
328_V 362_L 1.163 0.91
296_R 355_D 1.161 0.90
373_G 396_S 1.158 0.90
356_R 434_H 1.155 0.90
317_L 357_L 1.155 0.90
317_L 350_I 1.154 0.90
343_A 382_A 1.153 0.90
385_S 388_G 1.152 0.90
96_T 102_I 1.151 0.90
364_L 450_F 1.145 0.90
370_Q 411_P 1.136 0.89
107_D 110_K 1.136 0.89
12_A 223_R 1.129 0.89
332_A 378_I 1.125 0.88
318_N 322_N 1.123 0.88
316_D 346_T 1.123 0.88
370_Q 414_T 1.122 0.88
402_A 443_Q 1.12 0.88
22_V 54_N 1.118 0.88
228_S 426_V 1.118 0.88
107_D 111_V 1.116 0.88
11_L 14_W 1.114 0.88
265_G 293_R 1.108 0.87
364_L 427_V 1.097 0.87
257_R 372_I 1.092 0.86
394_T 444_E 1.088 0.86
96_T 182_F 1.088 0.86
246_G 416_K 1.085 0.86
262_S 269_Y 1.077 0.85
303_E 359_Q 1.074 0.85
399_G 419_G 1.071 0.85
442_S 446_K 1.068 0.85
268_K 288_A 1.067 0.85
251_G 414_T 1.066 0.85
389_V 454_L 1.061 0.84
263_I 291_A 1.06 0.84
287_M 380_V 1.057 0.84
21_V 36_R 1.056 0.84
251_G 370_Q 1.052 0.84
250_A 426_V 1.051 0.83
405_L 409_F 1.05 0.83
385_S 453_W 1.047 0.83
396_S 399_G 1.044 0.83
248_L 255_E 1.044 0.83
395_D 419_G 1.043 0.83
428_H 438_I 1.033 0.82
195_S 199_R 1.033 0.82
325_L 341_F 1.028 0.82
431_V 450_F 1.027 0.81
328_V 364_L 1.026 0.81
15_L 56_L 1.025 0.81
364_L 452_L 1.012 0.80
318_N 343_A 1.012 0.80
262_S 289_K 1.01 0.80
382_A 389_V 1.009 0.80
293_R 297_V 1.009 0.80
430_I 434_H 1.008 0.80
257_R 290_E 1.005 0.79
337_I 374_Q 1.005 0.79
248_L 412_Y 1.005 0.79
246_G 371_A 1.003 0.79
336_E 374_Q 1.003 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.59571000.508Contact Map0.739
4gczA20.78061000.517Contact Map0.629
3a0rA10.74191000.52Contact Map0.596
3d36A20.49891000.534Contact Map0.718
3jz3A20.46241000.539Contact Map0.695
4ew8A20.55051000.541Contact Map0.739
2btzA10.61000.548Contact Map0.566
2q8gA10.60651000.558Contact Map0.565
4e01A10.63661000.559Contact Map0.636
2c2aA10.50971000.562Contact Map0.711

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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