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FECE - Fe(3+) dicitrate transport ATP-binding protein FecE
UniProt: P15031 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10290
Length: 255 (236)
Sequences: 74532
Seq/Len: 315.81

FECE
Paralog alert: 0.94 [within 20: 0.85] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_A 205_C 3.265 1.00
4_R 24_S 3.148 1.00
29_K 207_Q 3.121 1.00
131_L 134_R 2.948 1.00
7_N 20_D 2.936 1.00
6_E 58_T 2.921 1.00
58_T 65_P 2.896 1.00
124_N 129_N 2.785 1.00
31_T 209_V 2.724 1.00
16_K 19_N 2.719 1.00
4_R 60_F 2.629 1.00
77_R 158_P 2.607 1.00
207_Q 219_Q 2.604 1.00
26_P 29_K 2.57 1.00
19_N 215_H 2.503 1.00
9_T 20_D 2.287 1.00
220_G 224_E 2.264 1.00
5_T 8_L 2.261 1.00
11_S 16_K 2.228 1.00
9_T 16_K 2.186 1.00
10_V 47_C 2.136 1.00
93_V 139_L 2.12 1.00
9_T 56_S 2.114 1.00
118_R 156_N 2.112 1.00
6_E 60_F 2.072 1.00
62_G 158_P 2.031 1.00
221_T 224_E 2.029 1.00
123_M 132_A 2.023 1.00
120_N 132_A 1.897 1.00
156_N 189_K 1.874 1.00
209_V 216_V 1.833 1.00
94_Q 132_A 1.793 1.00
27_T 158_P 1.791 1.00
125_Q 183_E 1.787 1.00
29_K 206_D 1.753 1.00
209_V 219_Q 1.743 1.00
94_Q 133_V 1.738 1.00
94_Q 120_N 1.738 1.00
12_Y 17_V 1.731 1.00
7_N 22_S 1.708 1.00
121_V 125_Q 1.699 1.00
10_V 55_Q 1.623 1.00
94_Q 98_S 1.596 1.00
183_E 186_T 1.585 1.00
45_L 194_V 1.583 1.00
94_Q 119_V 1.563 1.00
116_N 120_N 1.562 1.00
45_L 161_L 1.555 1.00
11_S 55_Q 1.542 1.00
94_Q 116_N 1.538 1.00
91_I 95_E 1.488 1.00
83_Q 141_G 1.466 1.00
118_R 121_V 1.461 1.00
23_L 209_V 1.442 1.00
25_L 31_T 1.429 1.00
18_L 47_C 1.426 1.00
125_Q 187_Q 1.416 1.00
134_R 138_E 1.401 0.99
10_V 52_L 1.398 0.99
6_E 24_S 1.384 0.99
5_T 48_F 1.382 0.99
60_F 65_P 1.358 0.99
129_N 132_A 1.344 0.99
47_C 54_P 1.337 0.99
120_N 124_N 1.332 0.99
9_T 19_N 1.326 0.99
220_G 225_V 1.322 0.99
120_N 129_N 1.306 0.99
5_T 23_L 1.301 0.99
70_S 73_Q 1.282 0.99
162_L 181_M 1.271 0.99
117_A 121_V 1.266 0.99
195_L 201_A 1.265 0.99
131_L 143_Q 1.261 0.99
96_L 151_M 1.248 0.99
98_S 119_V 1.244 0.98
8_L 54_P 1.241 0.98
62_G 77_R 1.237 0.98
97_V 154_A 1.232 0.98
31_T 219_Q 1.22 0.98
92_T 95_E 1.218 0.98
26_P 207_Q 1.206 0.98
10_V 43_T 1.203 0.98
118_R 122_A 1.183 0.98
44_L 211_M 1.178 0.98
98_S 116_N 1.176 0.98
6_E 22_S 1.171 0.98
97_V 123_M 1.149 0.97
5_T 44_L 1.124 0.97
93_V 147_A 1.114 0.96
79_S 157_T 1.109 0.96
49_S 80_L 1.108 0.96
127_R 176_D 1.106 0.96
31_T 207_Q 1.1 0.96
46_N 52_L 1.095 0.96
123_M 128_I 1.094 0.96
128_I 131_L 1.091 0.96
178_M 200_Q 1.089 0.96
30_I 191_V 1.084 0.96
65_P 68_M 1.078 0.95
212_A 217_M 1.077 0.95
174_Q 200_Q 1.071 0.95
11_S 17_V 1.065 0.95
121_V 124_N 1.063 0.95
184_L 189_K 1.062 0.95
12_Y 43_T 1.062 0.95
126_T 150_A 1.055 0.95
158_P 189_K 1.054 0.95
180_L 183_E 1.051 0.94
33_L 44_L 1.051 0.94
27_T 62_G 1.046 0.94
21_V 44_L 1.04 0.94
64_N 77_R 1.039 0.94
30_I 193_A 1.029 0.94
122_A 150_A 1.019 0.93
92_T 96_L 1.018 0.93
122_A 154_A 1.017 0.93
98_S 115_D 1.017 0.93
48_F 192_V 1.01 0.93
81_L 149_L 1.007 0.93
121_V 156_N 1.003 0.93
50_R 53_M 1.003 0.93
174_Q 197_D 1.003 0.93
49_S 161_L 1.003 0.93
125_Q 186_T 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9843100-0.001Contact Map0.859
2it1A20.97651000.002Contact Map0.858
1v43A10.97651000.003Contact Map0.813
2yyzA10.97651000.003Contact Map0.808
1oxxK10.98431000.005Contact Map0.785
1g29120.98431000.005Contact Map0.88
1z47A20.97651000.006Contact Map0.829
4hziA20.99221000.006Contact Map0.859
4g1uC20.97651000.006Contact Map0.739
3fvqA20.98431000.007Contact Map0.773

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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