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AMPP - Xaa-Pro aminopeptidase
UniProt: P15034 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10697
Length: 441 (434)
Sequences: 3155
Seq/Len: 7.27

AMPP
Paralog alert: 0.47 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: AMPP MAP1 PEPQ YPDF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
186_R 418_E 6.67 1.00
377_P 414_E 5.329 1.00
182_I 411_V 4.701 1.00
305_Y 412_I 4.559 1.00
187_R 190_E 2.904 1.00
78_F 117_Q 2.844 1.00
290_I 404_I 2.706 1.00
292_D 428_P 2.706 1.00
176_F 376_E 2.639 1.00
292_D 296_E 2.553 1.00
322_M 387_L 2.52 1.00
254_D 280_N 2.505 1.00
299_E 303_R 2.422 1.00
185_L 380_V 2.362 1.00
54_T 63_L 2.347 1.00
194_M 223_H 2.339 1.00
212_L 258_V 2.308 1.00
310_S 313_E 2.247 1.00
406_I 426_K 2.244 1.00
299_E 427_K 2.239 1.00
238_E 250_C 2.226 1.00
215_E 218_H 2.177 1.00
284_T 287_Q 2.158 1.00
193_A 424_V 2.12 1.00
357_L 409_D 2.042 1.00
293_I 325_G 2.037 1.00
16_L 53_F 2.034 1.00
48_S 360_D 2.01 1.00
198_R 219_E 2.01 1.00
382_T 409_D 1.972 1.00
411_V 420_L 1.956 1.00
208_F 251_E 1.945 1.00
315_T 319_V 1.942 1.00
300_T 303_R 1.93 1.00
304_L 317_E 1.922 1.00
192_T 273_I 1.873 1.00
286_A 289_E 1.867 1.00
301_S 318_V 1.861 1.00
285_Q 289_E 1.84 1.00
236_S 252_M 1.808 1.00
234_V 258_V 1.789 1.00
413_T 416_G 1.772 1.00
300_T 321_I 1.762 1.00
298_L 302_L 1.743 1.00
327_V 336_V 1.736 1.00
229_S 270_A 1.73 1.00
294_V 404_I 1.728 1.00
257_L 287_Q 1.718 1.00
210_Y 249_E 1.7 1.00
253_R 256_D 1.693 1.00
219_E 222_R 1.692 1.00
261_D 272_D 1.689 1.00
200_M 277_F 1.675 1.00
392_D 402_I 1.675 1.00
286_A 392_D 1.668 1.00
127_V 162_T 1.667 1.00
272_D 407_E 1.66 1.00
252_M 279_V 1.656 1.00
410_I 419_N 1.645 1.00
290_I 389_I 1.636 1.00
335_D 338_E 1.618 1.00
217_H 221_N 1.613 1.00
320_R 324_S 1.603 1.00
49_D 171_H 1.598 1.00
288_R 292_D 1.59 1.00
290_I 402_I 1.589 1.00
213_E 217_H 1.588 1.00
312_L 372_S 1.566 1.00
182_I 186_R 1.563 1.00
324_S 328_K 1.556 1.00
261_D 407_E 1.552 1.00
383_V 410_I 1.538 1.00
197_T 201_E 1.536 1.00
235_G 240_G 1.527 0.99
13_R 17_V 1.526 0.99
186_R 190_E 1.511 0.99
297_S 321_I 1.511 0.99
191_I 225_A 1.505 0.99
8_E 178_S 1.502 0.99
218_H 222_R 1.501 0.99
113_E 116_Q 1.485 0.99
291_Y 406_I 1.478 0.99
295_L 406_I 1.467 0.99
211_H 222_R 1.466 0.99
288_R 428_P 1.459 0.99
236_S 250_C 1.457 0.99
14_Q 18_E 1.451 0.99
250_C 256_D 1.445 0.99
375_L 412_I 1.437 0.99
301_S 314_V 1.428 0.99
53_F 170_V 1.416 0.99
212_L 252_M 1.414 0.99
413_T 418_E 1.402 0.99
296_E 300_T 1.399 0.99
198_R 201_E 1.399 0.99
196_H 273_I 1.398 0.99
11_R 15_A 1.397 0.99
375_L 381_L 1.393 0.99
192_T 271_G 1.388 0.99
318_V 349_F 1.388 0.99
37_S 40_S 1.388 0.99
214_G 218_H 1.371 0.99
186_R 411_V 1.37 0.99
327_V 339_L 1.364 0.99
307_P 417_N 1.353 0.98
411_V 418_E 1.352 0.98
191_I 268_G 1.346 0.98
183_A 187_R 1.338 0.98
380_V 420_L 1.338 0.98
265_E 270_A 1.328 0.98
305_Y 383_V 1.319 0.98
185_L 189_G 1.314 0.98
17_V 65_L 1.31 0.98
196_H 424_V 1.309 0.98
175_L 379_M 1.292 0.98
257_L 276_T 1.288 0.98
299_E 426_K 1.28 0.98
291_Y 426_K 1.265 0.97
396_P 399_Y 1.262 0.97
32_P 44_Y 1.247 0.97
15_A 18_E 1.24 0.97
302_L 419_N 1.239 0.97
320_R 337_D 1.239 0.97
202_K 215_E 1.231 0.97
261_D 274_T 1.231 0.97
12_R 178_S 1.225 0.97
109_L 113_E 1.215 0.96
264_C 271_G 1.205 0.96
184_V 267_K 1.203 0.96
183_A 186_R 1.196 0.96
243_L 351_H 1.191 0.96
306_R 309_T 1.19 0.96
179_P 183_A 1.183 0.96
356_W 365_G 1.18 0.96
236_S 256_D 1.178 0.95
76_V 109_L 1.176 0.95
13_R 75_S 1.176 0.95
237_G 256_D 1.175 0.95
239_N 250_C 1.174 0.95
127_V 164_I 1.17 0.95
15_A 173_M 1.167 0.95
296_E 324_S 1.166 0.95
10_Q 14_Q 1.165 0.95
298_L 408_D 1.163 0.95
356_W 363_D 1.148 0.95
172_E 376_E 1.148 0.95
74_H 107_R 1.148 0.95
33_E 41_E 1.146 0.95
225_A 264_C 1.143 0.94
315_T 353_L 1.139 0.94
54_T 75_S 1.138 0.94
313_E 316_G 1.135 0.94
380_V 411_V 1.133 0.94
172_E 373_R 1.132 0.94
205_P 254_D 1.13 0.94
285_Q 288_R 1.13 0.94
239_N 245_Y 1.128 0.94
318_V 353_L 1.128 0.94
323_V 339_L 1.127 0.94
50_F 61_A 1.126 0.94
21_Q 67_K 1.124 0.94
217_H 228_P 1.124 0.94
388_Y 403_G 1.123 0.94
293_I 296_E 1.122 0.94
189_G 193_A 1.121 0.94
357_L 380_V 1.119 0.94
376_E 379_M 1.116 0.93
307_P 413_T 1.114 0.93
244_H 362_H 1.102 0.93
302_L 410_I 1.101 0.93
219_E 223_H 1.091 0.92
302_L 383_V 1.086 0.92
189_G 409_D 1.075 0.92
278_P 283_F 1.069 0.91
317_E 320_R 1.069 0.91
343_N 346_R 1.068 0.91
309_T 317_E 1.063 0.91
75_S 105_V 1.063 0.91
410_I 417_N 1.06 0.91
257_L 278_P 1.058 0.91
203_C 277_F 1.057 0.91
25_A 164_I 1.054 0.91
300_T 317_E 1.049 0.90
212_L 234_V 1.048 0.90
272_D 355_H 1.046 0.90
381_L 412_I 1.043 0.90
203_C 212_L 1.041 0.90
197_T 425_V 1.038 0.90
305_Y 314_V 1.037 0.90
388_Y 405_R 1.036 0.90
240_G 259_L 1.034 0.90
291_Y 295_L 1.033 0.89
274_T 407_E 1.03 0.89
339_L 344_A 1.029 0.89
301_S 304_L 1.028 0.89
20_M 24_S 1.026 0.89
192_T 195_A 1.025 0.89
293_I 322_M 1.024 0.89
81_V 110_A 1.024 0.89
17_V 20_M 1.022 0.89
301_S 317_E 1.017 0.88
198_R 222_R 1.017 0.88
298_L 426_K 1.016 0.88
183_A 190_E 1.016 0.88
322_M 345_H 1.016 0.88
63_L 105_V 1.016 0.88
179_P 378_G 1.011 0.88
317_E 321_I 1.01 0.88
408_D 426_K 1.006 0.88
181_E 269_Y 1.005 0.88
316_G 320_R 1.005 0.88
314_V 317_E 1.004 0.88
187_R 191_I 1.003 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2v3zA10.99771000.119Contact Map0.835
2iw2A20.97051000.192Contact Map0.828
3ig4A60.93881000.206Contact Map0.829
3q6dA40.79371000.307Contact Map0.827
3l24A30.93651000.308Contact Map0.736
4fkcA10.82541000.311Contact Map0.754
3cb6A10.90021000.312Contact Map0.655
2zsgA20.78911000.314Contact Map0.839
3rvaA10.92521000.315Contact Map0.684
4egeA10.82091000.317Contact Map0.725

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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