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AROE - Shikimate dehydrogenase
UniProt: P15770 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10077
Length: 272 (265)
Sequences: 2888
Seq/Len: 10.90

AROE
Paralog alert: 0.33 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: AROE YDIB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_K 227_E 4.74 1.00
9_N 37_L 4.054 1.00
85_V 98_G 3.29 1.00
76_T 99_D 3.284 1.00
210_C 222_F 2.87 1.00
250_L 256_L 2.803 1.00
74_E 95_R 2.747 1.00
74_E 97_L 2.614 1.00
66_E 132_R 2.597 1.00
19_I 245_A 2.437 1.00
104_V 247_H 2.378 1.00
123_L 181_F 2.323 1.00
72_A 98_G 2.294 1.00
247_H 250_L 2.255 1.00
72_A 88_L 2.228 1.00
68_A 88_L 2.215 1.00
221_P 225_W 2.152 1.00
134_V 213_M 2.139 1.00
91_L 96_L 2.114 1.00
124_L 135_L 2.102 1.00
8_G 61_T 2.093 1.00
121_R 144_A 2.083 1.00
79_A 85_V 2.079 1.00
219_K 224_A 2.066 1.00
106_L 211_Y 2.035 1.00
156_E 160_K 2.002 1.00
67_E 70_A 1.983 1.00
59_N 248_A 1.976 1.00
58_A 88_L 1.925 1.00
68_A 72_A 1.922 1.00
72_A 85_V 1.901 1.00
69_F 75_L 1.887 1.00
89_M 251_L 1.865 1.00
4_Y 24_A 1.828 1.00
106_L 134_V 1.824 1.00
9_N 40_I 1.805 1.00
223_L 234_N 1.796 1.00
152_V 156_E 1.785 1.00
127_A 149_N 1.748 1.00
10_P 13_H 1.746 1.00
210_C 226_C 1.717 1.00
7_F 58_A 1.693 1.00
87_T 101_T 1.649 1.00
9_N 64_F 1.599 1.00
109_D 239_G 1.583 1.00
109_D 211_Y 1.581 1.00
77_E 80_A 1.58 1.00
130_A 213_M 1.575 1.00
3_T 34_G 1.551 1.00
108_S 111_E 1.55 1.00
75_L 98_G 1.534 1.00
149_N 189_S 1.533 1.00
191_G 214_F 1.523 1.00
64_F 67_E 1.506 1.00
49_A 52_S 1.501 1.00
249_F 253_H 1.493 1.00
76_T 97_L 1.492 1.00
123_L 148_T 1.482 1.00
6_V 11_I 1.473 1.00
9_N 39_P 1.472 1.00
24_A 31_H 1.461 1.00
73_D 95_R 1.449 1.00
108_S 243_A 1.448 1.00
106_L 185_I 1.445 1.00
88_L 96_L 1.438 1.00
5_A 36_V 1.421 1.00
205_H 208_I 1.414 1.00
82_A 103_G 1.407 0.99
132_R 161_L 1.398 0.99
151_T 154_R 1.393 0.99
78_R 99_D 1.389 0.99
42_D 45_N 1.384 0.99
144_A 169_Q 1.368 0.99
224_A 228_Q 1.338 0.99
75_L 85_V 1.334 0.99
121_R 182_D 1.333 0.99
142_D 145_V 1.325 0.99
99_D 251_L 1.323 0.99
6_V 35_R 1.319 0.99
121_R 146_T 1.313 0.99
78_R 140_S 1.307 0.99
122_I 142_D 1.306 0.99
4_Y 56_K 1.296 0.99
29_I 253_H 1.291 0.99
38_A 46_T 1.271 0.99
103_G 137_P 1.27 0.99
4_Y 31_H 1.265 0.99
45_N 48_N 1.257 0.99
44_I 48_N 1.257 0.99
50_F 58_A 1.255 0.99
188_T 191_G 1.254 0.99
243_A 259_V 1.246 0.98
75_L 80_A 1.238 0.98
8_G 11_I 1.205 0.98
62_V 189_S 1.193 0.98
138_L 185_I 1.191 0.98
122_I 138_L 1.18 0.98
69_F 72_A 1.18 0.98
89_M 92_E 1.173 0.98
11_I 37_L 1.17 0.97
225_W 229_R 1.168 0.97
22_Q 26_Q 1.162 0.97
131_S 187_A 1.16 0.97
208_I 232_K 1.159 0.97
92_E 97_L 1.157 0.97
18_F 22_Q 1.146 0.97
72_A 75_L 1.141 0.97
33_Y 59_N 1.134 0.97
43_F 68_A 1.13 0.97
5_A 58_A 1.129 0.97
92_E 95_R 1.127 0.97
136_L 140_S 1.125 0.97
113_L 235_A 1.108 0.96
66_E 154_R 1.106 0.96
12_A 37_L 1.094 0.96
81_L 136_L 1.093 0.96
155_A 159_A 1.089 0.96
227_E 234_N 1.087 0.96
89_M 99_D 1.081 0.95
5_A 35_R 1.078 0.95
39_P 42_D 1.073 0.95
20_H 245_A 1.07 0.95
3_T 32_P 1.056 0.95
50_F 55_G 1.052 0.95
135_L 162_F 1.049 0.94
11_I 14_S 1.049 0.94
123_L 184_I 1.047 0.94
21_Q 32_P 1.034 0.94
7_F 60_V 1.032 0.94
242_V 246_A 1.028 0.94
75_L 79_A 1.021 0.93
38_A 64_F 1.018 0.93
129_G 133_G 1.013 0.93
146_T 181_F 1.011 0.93
149_N 155_A 1.01 0.93
46_T 49_A 1.008 0.93
187_A 213_M 1.005 0.93
20_H 87_T 1.002 0.92
36_V 55_G 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1npyA40.94851000.18Contact Map0.778
3t4eA20.97791000.198Contact Map0.785
3phhA10.93381000.221Contact Map0.772
3tnlA40.96691000.231Contact Map0.821
2o7sA10.97431000.239Contact Map0.772
3pwzA10.98161000.24Contact Map0.764
3fbtA40.96691000.252Contact Map0.835
3jyoA10.97431000.257Contact Map0.778
2d5cA20.95591000.261Contact Map0.767
3donA10.96691000.274Contact Map0.762

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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