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CYSA - Sulfate/thiosulfate import ATP-binding protein CysA
UniProt: P16676 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10183
Length: 365 (345)
Sequences: 8989
Seq/Len: 26.06

CYSA
Paralog alert: 0.82 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_D 223_Q 4.607 1.00
32_A 204_A 4.426 1.00
122_E 127_A 4.137 1.00
29_Q 206_R 3.829 1.00
58_H 65_D 3.751 1.00
216_E 230_T 3.682 1.00
4_E 24_D 3.407 1.00
294_V 310_V 3.317 1.00
6_A 58_H 3.163 1.00
114_K 118_T 3.139 1.00
109_N 112_A 2.978 1.00
297_L 311_Q 2.855 1.00
7_N 20_D 2.827 1.00
129_L 132_R 2.753 1.00
121_L 130_A 2.73 1.00
19_N 214_N 2.693 1.00
92_F 131_D 2.649 1.00
92_F 96_A 2.58 1.00
7_N 22_S 2.568 1.00
116_K 154_E 2.547 1.00
92_F 118_T 2.526 1.00
208_V 215_I 2.455 1.00
181_Q 185_E 2.452 1.00
62_H 156_Q 2.452 1.00
120_L 152_A 2.44 1.00
31_V 208_V 2.425 1.00
92_F 117_V 2.418 1.00
47_I 59_I 2.401 1.00
220_A 223_Q 2.401 1.00
295_Q 335_R 2.401 1.00
293_P 335_R 2.345 1.00
18_L 47_I 2.306 1.00
92_F 114_K 2.263 1.00
61_F 66_V 2.243 1.00
64_T 156_Q 2.212 1.00
48_I 191_V 2.168 1.00
208_V 218_A 2.133 1.00
3_I 157_I 2.126 1.00
16_Q 19_N 2.104 1.00
211_S 216_E 2.066 1.00
4_E 60_R 2.053 1.00
75_K 156_Q 2.035 1.00
26_P 29_Q 2.004 1.00
96_A 117_V 2.002 1.00
5_I 8_I 1.967 1.00
331_Q 334_E 1.964 1.00
231_R 272_D 1.958 1.00
124_V 148_A 1.954 1.00
60_R 65_D 1.941 1.00
295_Q 311_Q 1.914 1.00
160_L 190_S 1.911 1.00
9_K 20_D 1.9 1.00
46_R 52_E 1.878 1.00
11_S 16_Q 1.854 1.00
115_A 119_K 1.847 1.00
125_Q 174_E 1.837 1.00
95_I 148_A 1.826 1.00
5_I 48_I 1.824 1.00
86_F 98_G 1.809 1.00
9_K 56_S 1.8 1.00
9_K 16_Q 1.796 1.00
6_A 60_R 1.792 1.00
112_A 115_A 1.792 1.00
209_V 233_V 1.774 1.00
10_K 47_I 1.766 1.00
293_P 337_F 1.763 1.00
113_I 117_V 1.722 1.00
96_A 113_I 1.712 1.00
240_V 274_F 1.701 1.00
64_T 69_L 1.7 1.00
231_R 242_R 1.659 1.00
10_K 52_E 1.628 1.00
231_R 235_E 1.623 1.00
225_W 278_W 1.614 1.00
111_A 115_A 1.599 1.00
47_I 54_Q 1.581 1.00
18_L 44_L 1.574 1.00
235_E 242_R 1.563 1.00
108_P 113_I 1.544 1.00
31_V 218_A 1.541 1.00
5_I 23_L 1.532 1.00
95_I 121_L 1.53 1.00
108_P 112_A 1.529 1.00
90_T 93_D 1.523 1.00
98_G 153_V 1.497 1.00
118_T 130_A 1.489 1.00
60_R 63_G 1.482 1.00
66_V 69_L 1.466 1.00
70_H 73_D 1.455 1.00
119_K 154_E 1.453 1.00
39_S 210_M 1.451 1.00
21_I 44_L 1.449 1.00
120_L 151_L 1.447 1.00
116_K 119_K 1.439 1.00
10_K 55_T 1.432 1.00
242_R 272_D 1.426 1.00
112_A 116_K 1.426 1.00
305_Y 323_V 1.422 1.00
31_V 206_R 1.418 1.00
246_T 270_P 1.405 0.99
164_F 179_L 1.398 0.99
223_Q 227_E 1.388 0.99
119_K 122_E 1.355 0.99
23_L 208_V 1.354 0.99
183_H 188_F 1.336 0.99
26_P 206_R 1.333 0.99
93_D 100_T 1.332 0.99
222_D 226_R 1.331 0.99
90_T 133_Y 1.33 0.99
54_Q 59_I 1.324 0.99
180_R 203_V 1.311 0.99
183_H 190_S 1.307 0.99
299_A 308_L 1.294 0.99
58_H 67_S 1.293 0.99
11_S 56_S 1.29 0.99
4_E 63_G 1.274 0.99
211_S 232_F 1.269 0.99
118_T 122_E 1.268 0.99
54_Q 67_S 1.268 0.99
164_F 192_F 1.267 0.99
18_L 21_I 1.267 0.99
77_G 153_V 1.259 0.99
5_I 44_L 1.258 0.99
244_Q 270_P 1.254 0.99
23_L 218_A 1.25 0.99
310_V 338_V 1.249 0.99
118_T 127_A 1.243 0.98
110_A 114_K 1.235 0.98
245_G 271_V 1.233 0.98
65_D 68_R 1.224 0.98
30_M 183_H 1.208 0.98
154_E 185_E 1.205 0.98
9_K 19_N 1.186 0.98
296_V 308_L 1.182 0.98
33_L 208_V 1.176 0.98
27_S 62_H 1.166 0.97
30_M 203_V 1.164 0.97
11_S 17_V 1.149 0.97
226_R 301_P 1.148 0.97
86_F 153_V 1.143 0.97
6_A 22_S 1.143 0.97
100_T 110_A 1.142 0.97
244_Q 272_D 1.131 0.97
8_I 54_Q 1.124 0.97
206_R 218_A 1.123 0.97
77_G 190_S 1.12 0.96
7_N 56_S 1.117 0.96
119_K 185_E 1.108 0.96
121_L 126_L 1.098 0.96
8_I 47_I 1.097 0.96
275_L 280_V 1.089 0.96
217_Q 233_V 1.082 0.96
125_Q 178_W 1.065 0.95
219_D 224_V 1.057 0.95
197_Q 236_F 1.051 0.94
170_Q 235_E 1.048 0.94
248_R 253_H 1.034 0.94
83_Y 166_A 1.032 0.94
44_L 210_M 1.029 0.94
93_D 96_A 1.027 0.94
283_S 337_F 1.023 0.93
69_L 73_D 1.021 0.93
253_H 258_R 1.019 0.93
294_V 336_L 1.013 0.93
310_V 322_V 1.009 0.93
11_S 55_T 1.008 0.93
227_E 344_R 1.005 0.93
39_S 44_L 1.004 0.93
246_T 253_H 1.003 0.93
95_I 120_L 1.002 0.92
95_I 117_V 1.002 0.92
59_I 66_V 1.002 0.92
160_L 192_F 1.001 0.92
30_M 190_S 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2it1A20.95891000.236Contact Map0.859
1v43A10.95341000.237Contact Map0.848
1oxxK10.92881000.239Contact Map0.734
3fvqA20.96441000.248Contact Map0.758
1g29120.95341000.251Contact Map0.867
3rlfA20.98081000.251Contact Map0.82
2yyzA10.95071000.255Contact Map0.78
3d31A20.92051000.257Contact Map0.731
1z47A20.93151000.266Contact Map0.835
3gd7A40.93421000.342Contact Map0.699

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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