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PHNC - Phosphonates import ATP-binding protein PhnC
UniProt: P16677 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10713
Length: 262 (240)
Sequences: 69139
Seq/Len: 288.08

PHNC
Paralog alert: 0.94 [within 20: 0.83] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
34_A 220_C 3.466 1.00
6_R 26_N 3.14 1.00
145_F 148_Q 3.076 1.00
31_E 222_R 3.036 1.00
63_H 70_T 2.989 1.00
8_E 63_H 2.924 1.00
9_K 22_A 2.888 1.00
33_V 224_V 2.819 1.00
18_Q 21_H 2.788 1.00
138_T 143_V 2.74 1.00
6_R 65_E 2.717 1.00
87_H 172_K 2.626 1.00
21_H 230_H 2.571 1.00
7_V 10_L 2.415 1.00
28_H 31_E 2.401 1.00
13_T 18_Q 2.306 1.00
11_A 22_A 2.29 1.00
222_R 234_D 2.283 1.00
103_V 153_L 2.252 1.00
235_G 239_Q 2.242 1.00
11_A 18_Q 2.231 1.00
132_R 170_Q 2.216 1.00
67_L 172_K 2.129 1.00
12_K 49_H 2.099 1.00
134_L 146_A 2.028 1.00
11_A 58_K 2.026 1.00
137_L 146_A 1.976 1.00
104_L 147_H 1.964 1.00
236_S 239_Q 1.948 1.00
8_E 65_E 1.901 1.00
104_L 134_L 1.85 1.00
104_L 146_A 1.843 1.00
31_E 221_E 1.791 1.00
29_H 172_K 1.785 1.00
9_K 24_D 1.783 1.00
170_Q 204_I 1.782 1.00
224_V 231_V 1.779 1.00
197_D 201_N 1.777 1.00
139_R 197_D 1.771 1.00
14_F 19_A 1.739 1.00
12_K 57_D 1.649 1.00
224_V 234_D 1.615 1.00
104_L 133_A 1.615 1.00
93_Q 155_G 1.608 1.00
148_Q 152_T 1.573 1.00
13_T 57_D 1.552 1.00
132_R 135_Q 1.521 1.00
135_Q 139_R 1.519 1.00
199_N 221_E 1.511 1.00
125_F 128_E 1.478 1.00
20_L 49_H 1.444 1.00
65_E 70_T 1.435 1.00
130_K 134_L 1.43 1.00
12_K 54_I 1.417 1.00
8_E 26_N 1.415 1.00
104_L 108_L 1.414 1.00
47_L 209_T 1.406 0.99
143_V 146_A 1.397 0.99
25_L 224_V 1.383 0.99
27_I 33_V 1.382 0.99
49_H 56_G 1.378 0.99
104_L 130_K 1.342 0.99
131_Q 135_Q 1.335 0.99
210_L 216_A 1.327 0.99
10_L 56_G 1.303 0.99
107_V 168_M 1.301 0.99
139_R 201_N 1.297 0.99
102_S 105_E 1.295 0.99
176_A 195_L 1.295 0.99
7_V 50_L 1.29 0.99
11_A 21_H 1.288 0.99
33_V 234_D 1.285 0.99
139_R 202_D 1.28 0.99
67_L 87_H 1.267 0.99
145_F 157_Q 1.265 0.99
134_L 138_T 1.264 0.99
4_I 67_L 1.261 0.99
103_V 161_V 1.25 0.99
7_V 25_L 1.244 0.98
8_E 24_D 1.227 0.98
108_L 133_A 1.221 0.98
106_N 165_R 1.215 0.98
134_L 143_V 1.207 0.98
108_L 129_Q 1.198 0.98
132_R 136_A 1.196 0.98
48_R 54_I 1.186 0.98
235_G 240_F 1.185 0.98
7_V 46_L 1.18 0.98
172_K 204_I 1.164 0.97
140_V 164_A 1.163 0.97
47_L 175_L 1.15 0.97
28_H 222_R 1.147 0.97
196_R 199_N 1.143 0.97
50_L 207_V 1.133 0.97
32_M 199_N 1.118 0.96
194_T 197_D 1.117 0.96
149_R 152_T 1.116 0.96
199_N 206_V 1.101 0.96
32_M 206_V 1.088 0.96
198_I 204_I 1.077 0.95
12_K 45_T 1.07 0.95
108_L 130_K 1.069 0.95
49_H 64_I 1.062 0.95
13_T 19_A 1.056 0.95
33_V 222_R 1.055 0.95
188_A 215_Y 1.048 0.94
10_L 49_H 1.031 0.94
102_S 149_R 1.031 0.94
91_I 163_I 1.025 0.93
29_H 67_L 1.025 0.93
192_M 215_Y 1.021 0.93
227_R 232_F 1.02 0.93
46_L 226_L 1.019 0.93
190_I 193_D 1.018 0.93
51_S 90_Y 1.016 0.93
141_G 190_I 1.01 0.93
9_K 58_K 1.008 0.93
136_A 164_A 1.008 0.93
23_V 46_L 1.007 0.93
196_R 200_Q 1.006 0.93
35_L 46_L 1.004 0.93
136_A 168_M 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fvqA20.9466100-0.012Contact Map0.765
1v43A10.9313100-0.009Contact Map0.816
3tuiC40.9504100-0.007Contact Map0.87
1oxxK10.9466100-0.006Contact Map0.792
2it1A20.9275100-0.006Contact Map0.866
1g29120.9466100-0.003Contact Map0.893
2yyzA10.9275100-0.001Contact Map0.804
3rlfA20.92751000Contact Map0.828
1z47A20.93131000.002Contact Map0.826
3d31A20.90461000.016Contact Map0.814

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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