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PHNK - Putative phosphonates utilization ATP-binding protein PhnK
UniProt: P16678 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10720
Length: 252 (247)
Sequences: 71850
Seq/Len: 290.89

PHNK
Paralog alert: 0.95 [within 20: 0.88] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
35_G 213_A 3.389 1.00
7_S 27_D 3.209 1.00
32_E 215_R 3.196 1.00
9_N 61_E 3.007 1.00
84_E 165_K 2.999 1.00
10_N 23_D 2.971 1.00
61_E 68_S 2.919 1.00
138_R 141_D 2.857 1.00
34_L 217_L 2.818 1.00
7_S 63_H 2.672 1.00
22_S 223_Q 2.537 1.00
29_W 32_E 2.462 1.00
215_R 227_S 2.445 1.00
12_T 23_D 2.339 1.00
8_V 11_L 2.33 1.00
19_K 22_S 2.299 1.00
13_H 50_S 2.289 1.00
65_E 165_K 2.278 1.00
124_T 163_H 2.274 1.00
228_G 232_R 2.115 1.00
229_L 232_R 2.086 1.00
102_A 146_F 2.081 1.00
130_E 135_P 2.068 1.00
217_L 224_V 2.034 1.00
12_T 59_Q 2.006 1.00
126_Q 139_I 1.999 1.00
103_G 140_D 1.964 1.00
129_L 139_I 1.955 1.00
14_L 19_K 1.94 1.00
30_P 165_K 1.922 1.00
190_G 194_E 1.92 1.00
9_N 63_H 1.848 1.00
12_T 19_K 1.845 1.00
32_E 214_D 1.806 1.00
10_N 25_S 1.798 1.00
15_Y 20_G 1.797 1.00
131_E 190_G 1.778 1.00
103_G 139_I 1.768 1.00
131_E 195_L 1.736 1.00
103_G 126_Q 1.723 1.00
217_L 227_S 1.699 1.00
163_H 197_L 1.696 1.00
124_T 127_K 1.656 1.00
13_H 58_Q 1.646 1.00
103_G 125_A 1.61 1.00
127_K 131_E 1.592 1.00
141_D 145_T 1.575 1.00
65_E 84_E 1.542 1.00
90_Q 148_G 1.528 1.00
131_E 194_E 1.523 1.00
228_G 233_V 1.503 1.00
9_N 27_D 1.482 1.00
122_R 126_Q 1.467 1.00
14_L 58_Q 1.46 1.00
192_V 214_D 1.456 1.00
21_F 50_S 1.431 1.00
48_L 202_V 1.419 1.00
63_H 68_S 1.41 1.00
8_V 51_I 1.406 0.99
203_T 209_A 1.388 0.99
68_S 71_A 1.375 0.99
13_H 55_L 1.371 0.99
123_A 127_K 1.366 0.99
28_L 34_L 1.36 0.99
107_G 125_A 1.357 0.99
26_F 217_L 1.357 0.99
15_Y 46_T 1.344 0.99
12_T 22_S 1.34 0.99
107_G 121_I 1.337 0.99
130_E 136_A 1.335 0.99
73_S 76_D 1.334 0.99
169_M 188_L 1.294 0.99
50_S 57_P 1.286 0.99
103_G 122_R 1.284 0.99
8_V 26_F 1.281 0.99
124_T 128_W 1.279 0.99
106_I 161_V 1.276 0.99
5_L 65_E 1.274 0.99
34_L 227_S 1.274 0.99
103_G 107_G 1.264 0.99
101_S 104_G 1.26 0.99
9_N 25_S 1.254 0.99
128_W 161_V 1.233 0.98
33_V 192_V 1.23 0.98
189_R 192_V 1.212 0.98
11_L 57_P 1.194 0.98
33_V 199_V 1.189 0.98
192_V 199_V 1.175 0.98
102_A 154_L 1.169 0.97
163_H 195_L 1.169 0.97
48_L 168_F 1.166 0.97
77_R 81_L 1.144 0.97
47_L 219_M 1.144 0.97
50_S 62_I 1.141 0.97
187_L 190_G 1.127 0.97
13_H 46_T 1.115 0.96
126_Q 130_E 1.113 0.96
29_W 215_R 1.109 0.96
105_N 158_R 1.1 0.96
51_I 200_V 1.1 0.96
185_L 208_V 1.099 0.96
88_V 156_I 1.098 0.96
30_P 65_E 1.095 0.96
8_V 47_L 1.087 0.96
24_V 47_L 1.084 0.96
117_H 120_D 1.082 0.96
181_Q 208_V 1.081 0.95
165_K 197_L 1.079 0.95
107_G 122_R 1.077 0.95
132_V 157_A 1.074 0.95
191_L 197_L 1.071 0.95
239_H 242_T 1.068 0.95
169_M 199_V 1.064 0.95
146_F 154_L 1.063 0.95
127_K 130_E 1.057 0.95
49_K 55_L 1.054 0.95
167_V 199_V 1.044 0.94
52_S 87_V 1.043 0.94
10_N 59_Q 1.043 0.94
4_P 29_W 1.041 0.94
36_I 200_V 1.036 0.94
142_L 145_T 1.036 0.94
14_L 20_G 1.033 0.94
34_L 215_R 1.032 0.94
104_G 107_G 1.025 0.93
138_R 150_M 1.016 0.93
88_V 169_M 1.016 0.93
52_S 168_F 1.014 0.93
36_I 47_L 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fwiB10.996100-0.026Contact Map0.728
3tuiC40.9802100-0.026Contact Map0.881
1g29120.9762100-0.025Contact Map0.898
2it1A20.9524100-0.022Contact Map0.864
2yyzA10.9524100-0.018Contact Map0.806
1v43A10.9563100-0.018Contact Map0.823
1oxxK10.9722100-0.017Contact Map0.799
3rlfA20.9524100-0.01Contact Map0.833
3fvqA20.9722100-0.009Contact Map0.781
1z47A20.9603100-0.004Contact Map0.845

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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