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PHNL - Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL
UniProt: P16679 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10721
Length: 226 (218)
Sequences: 71457
Seq/Len: 327.78

PHNL
Paralog alert: 0.94 [within 20: 0.86] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_V 216_A 3.293 1.00
35_E 218_R 3.168 1.00
3_N 30_T 3.119 1.00
6_N 26_R 2.888 1.00
5_Q 64_Q 2.881 1.00
91_T 169_P 2.87 1.00
37_V 220_H 2.846 1.00
64_Q 75_D 2.829 1.00
22_P 25_N 2.796 1.00
141_R 145_L 2.638 1.00
3_N 66_Q 2.619 1.00
32_N 35_E 2.423 1.00
134_T 139_P 2.413 1.00
8_S 26_R 2.288 1.00
4_V 7_V 2.236 1.00
9_K 53_S 2.226 1.00
10_T 22_P 2.176 1.00
128_K 167_D 2.171 1.00
68_K 169_P 2.149 1.00
8_S 22_P 2.063 1.00
107_A 150_F 2.026 1.00
8_S 62_E 2.007 1.00
108_L 144_H 1.923 1.00
5_Q 66_Q 1.878 1.00
33_A 169_P 1.84 1.00
35_E 217_D 1.788 1.00
6_N 28_S 1.742 1.00
194_E 197_T 1.738 1.00
167_D 200_A 1.722 1.00
135_R 198_R 1.703 1.00
135_R 194_E 1.685 1.00
11_F 23_V 1.682 1.00
9_K 61_D 1.639 1.00
108_L 130_A 1.639 1.00
130_A 142_L 1.58 1.00
128_K 131_R 1.566 1.00
121_P 124_A 1.554 1.00
131_R 135_R 1.546 1.00
108_L 129_A 1.546 1.00
145_L 149_T 1.534 1.00
97_Q 152_G 1.491 1.00
9_K 58_Y 1.477 1.00
133_L 142_L 1.476 1.00
126_A 130_A 1.45 1.00
51_L 205_I 1.441 1.00
10_T 61_D 1.431 1.00
5_Q 30_T 1.417 1.00
31_V 37_V 1.381 0.99
66_Q 75_D 1.377 0.99
4_V 54_L 1.375 0.99
68_K 91_T 1.36 0.99
24_L 53_S 1.346 0.99
112_M 125_C 1.342 0.99
29_L 220_H 1.34 0.99
112_M 129_A 1.332 0.99
173_L 192_I 1.327 0.99
127_A 131_R 1.324 0.99
108_L 126_A 1.318 0.99
8_S 25_N 1.314 0.99
108_L 112_M 1.314 0.99
53_S 60_P 1.305 0.99
4_V 29_L 1.279 0.99
206_F 212_R 1.271 0.99
80_P 83_K 1.264 0.99
108_L 142_L 1.256 0.99
11_F 49_T 1.243 0.98
111_V 165_I 1.235 0.98
7_V 60_P 1.235 0.98
110_V 162_R 1.233 0.98
5_Q 28_S 1.233 0.98
106_S 109_E 1.232 0.98
51_L 172_L 1.228 0.98
75_D 78_T 1.222 0.98
128_K 132_L 1.167 0.97
107_A 158_V 1.164 0.97
36_C 202_I 1.162 0.97
135_R 197_T 1.148 0.97
54_L 203_V 1.147 0.97
185_S 211_V 1.136 0.97
132_L 165_I 1.133 0.97
139_P 142_L 1.132 0.97
130_A 134_T 1.127 0.97
1_M 68_K 1.12 0.96
189_V 211_V 1.116 0.96
4_V 50_L 1.107 0.96
37_V 218_R 1.104 0.96
112_M 126_A 1.097 0.96
50_L 222_M 1.092 0.96
32_N 218_R 1.086 0.96
167_D 198_R 1.076 0.95
191_L 194_E 1.074 0.95
68_K 74_V 1.071 0.95
52_R 58_Y 1.07 0.95
150_F 158_V 1.069 0.95
9_K 49_T 1.063 0.95
95_V 160_I 1.061 0.95
169_P 200_A 1.059 0.95
33_A 68_K 1.044 0.94
55_Y 94_W 1.043 0.94
136_L 161_A 1.04 0.94
173_L 202_I 1.024 0.93
146_A 149_T 1.024 0.93
115_L 165_I 1.022 0.93
195_A 198_R 1.017 0.93
27_A 50_L 1.017 0.93
105_I 109_E 1.013 0.93
53_S 65_I 1.009 0.93
95_V 173_L 1.009 0.93
171_L 202_I 1.006 0.93
109_E 112_M 1.003 0.93
124_A 127_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9602100-0.062Contact Map0.887
1g29120.9469100-0.052Contact Map0.896
1v43A10.9204100-0.05Contact Map0.822
1oxxK10.9513100-0.049Contact Map0.816
2it1A20.9204100-0.047Contact Map0.865
2yyzA10.9204100-0.047Contact Map0.806
1z47A20.9248100-0.044Contact Map0.828
3rlfA20.9204100-0.044Contact Map0.849
3fvqA20.9381100-0.04Contact Map0.772
3d31A20.9027100-0.026Contact Map0.798

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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