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PHNE - Putative phosphonates transport system permease protein PhnE
UniProt: P16683 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11283
Length: 259 (208)
Sequences: 7064
Seq/Len: 33.96

PHNE
Paralog alert: 0.88 [within 20: 0.35] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
174_N 177_E 3.718 1.00
137_G 209_V 3.45 1.00
82_L 142_F 3.217 1.00
196_L 251_S 3.111 1.00
229_Q 232_Q 2.932 1.00
70_A 74_Q 2.597 1.00
176_L 180_L 2.582 1.00
168_I 178_E 2.565 1.00
249_F 253_R 2.531 1.00
76_A 203_V 2.5 1.00
90_F 146_T 2.455 1.00
117_I 122_F 2.425 1.00
91_G 153_L 2.416 1.00
253_R 256_K 2.285 1.00
93_M 107_V 2.277 1.00
102_W 106_P 2.202 1.00
165_V 178_E 2.177 1.00
164_P 186_Q 2.17 1.00
66_L 70_A 2.15 1.00
169_R 178_E 2.144 1.00
111_M 150_S 2.094 1.00
156_A 191_L 2.05 1.00
90_F 150_S 1.999 1.00
102_W 105_Q 1.995 1.00
241_I 245_S 1.956 1.00
221_L 237_M 1.911 1.00
80_T 199_F 1.857 1.00
69_M 243_T 1.849 1.00
253_R 257_H 1.832 1.00
86_L 146_T 1.819 1.00
245_S 249_F 1.812 1.00
78_W 138_V 1.743 1.00
71_V 74_Q 1.713 1.00
83_A 145_T 1.639 1.00
85_V 89_P 1.638 1.00
165_V 169_R 1.585 1.00
168_I 173_A 1.538 1.00
207_T 240_I 1.519 1.00
159_A 190_L 1.511 1.00
82_L 138_V 1.51 1.00
149_L 195_S 1.5 1.00
203_V 247_L 1.458 1.00
169_R 175_K 1.453 1.00
250_L 253_R 1.453 1.00
74_Q 78_W 1.45 1.00
95_A 157_V 1.446 1.00
95_A 158_E 1.444 1.00
168_I 182_G 1.426 1.00
173_A 177_E 1.421 1.00
94_S 108_R 1.415 1.00
67_T 70_A 1.407 0.99
123_A 140_A 1.402 0.99
74_Q 134_P 1.397 0.99
250_L 254_L 1.387 0.99
134_P 138_V 1.373 0.99
153_L 191_L 1.367 0.99
89_P 93_M 1.361 0.99
87_S 149_L 1.351 0.99
249_F 252_Q 1.351 0.99
86_L 142_F 1.341 0.99
177_E 181_Y 1.318 0.99
75_I 209_V 1.308 0.99
149_L 198_R 1.304 0.99
126_F 140_A 1.304 0.99
117_I 144_H 1.277 0.99
123_A 208_V 1.262 0.99
88_I 153_L 1.258 0.99
90_F 107_V 1.249 0.99
157_V 183_V 1.242 0.98
133_G 214_A 1.234 0.98
64_D 67_T 1.229 0.98
174_N 178_E 1.21 0.98
246_L 250_L 1.202 0.98
76_A 206_A 1.191 0.98
79_G 142_F 1.19 0.98
101_W 105_Q 1.19 0.98
79_G 202_N 1.179 0.98
91_G 157_V 1.168 0.97
80_T 202_N 1.166 0.97
106_P 110_L 1.143 0.97
201_S 205_S 1.139 0.97
224_A 230_F 1.117 0.96
62_W 66_L 1.114 0.96
109_R 113_A 1.098 0.96
114_C 143_I 1.097 0.96
77_V 81_A 1.089 0.96
79_G 141_L 1.086 0.96
175_K 179_I 1.086 0.96
138_V 142_F 1.084 0.96
81_A 85_V 1.079 0.95
177_E 180_L 1.067 0.95
123_A 209_V 1.063 0.95
72_T 203_V 1.059 0.95
221_L 233_T 1.045 0.94
122_F 144_H 1.044 0.94
104_Y 108_R 1.042 0.94
151_K 154_S 1.04 0.94
67_T 71_V 1.039 0.94
141_L 206_A 1.034 0.94
219_V 222_W 1.033 0.94
87_S 150_S 1.026 0.94
135_F 139_L 1.026 0.94
124_M 128_V 1.024 0.93
165_V 183_V 1.02 0.93
144_H 205_S 1.009 0.93
78_W 81_A 1.006 0.93
160_I 187_V 1.003 0.93
238_V 242_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.783899.90.568Contact Map0.802
3d31C20.957599.90.574Contact Map0.595
2onkC40.957599.90.589Contact Map0.652
3rlfF10.988499.90.604Contact Map0.69
3rlfG10.980799.80.633Contact Map0.524
3rqwA100.43633.40.962Contact Map0.29
1rh5B10.27031.90.966Contact Map0.664
3w9iA60.84941.50.968Contact Map0.115
4dx5A30.8611.40.969Contact Map0.192
2ksfA10.391.20.97Contact Map0.354

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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