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CIRA - Colicin I receptor
UniProt: P17315 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10155
Length: 663 (625)
Sequences: 17216
Seq/Len: 27.55

CIRA
Paralog alert: 0.93 [within 20: 0.34] - ratio of genomes with paralogs
Cluster includes: BTUB CIRA FECA FEPA FHUA FHUE FIU YDDB YNCD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
549_Y 571_H 5.639 1.00
593_G 613_T 4.745 1.00
479_R 529_Q 4.535 1.00
382_V 394_W 4.359 1.00
384_M 392_E 4.155 1.00
615_W 637_G 4.087 1.00
408_V 459_L 4.023 1.00
414_W 453_E 3.954 1.00
330_Q 368_D 3.699 1.00
416_T 453_E 3.505 1.00
588_S 620_A 3.31 1.00
376_L 402_Y 3.217 1.00
56_Q 60_Q 3.195 1.00
630_R 658_A 3.187 1.00
375_P 402_Y 3.165 1.00
132_R 156_I 3.086 1.00
130_I 155_I 3.064 1.00
551_Y 571_H 2.993 1.00
199_L 243_W 2.954 1.00
475_V 533_T 2.936 1.00
335_G 365_F 2.85 1.00
595_Y 613_T 2.794 1.00
593_G 615_W 2.723 1.00
546_S 576_T 2.692 1.00
408_V 461_Y 2.648 1.00
404_A 410_V 2.613 1.00
471_V 537_I 2.606 1.00
527_R 557_V 2.595 1.00
598_Q 608_T 2.585 1.00
384_M 394_W 2.511 1.00
595_Y 611_G 2.451 1.00
55_T 58_D 2.442 1.00
246_N 249_H 2.434 1.00
74_V 135_V 2.422 1.00
592_S 616_N 2.414 1.00
631_A 655_Y 2.397 1.00
590_Y 618_G 2.38 1.00
376_L 400_L 2.376 1.00
340_H 360_S 2.376 1.00
594_H 616_N 2.374 1.00
591_V 615_W 2.363 1.00
473_S 535_L 2.361 1.00
478_F 552_N 2.351 1.00
543_W 577_L 2.349 1.00
627_V 661_Y 2.334 1.00
378_L 400_L 2.309 1.00
632_G 656_F 2.28 1.00
617_T 636_L 2.266 1.00
336_G 362_Y 2.216 1.00
203_A 239_V 2.203 1.00
338_W 362_Y 2.201 1.00
169_T 660_D 2.194 1.00
542_E 579_W 2.193 1.00
380_T 398_A 2.181 1.00
479_R 527_R 2.177 1.00
56_Q 158_K 2.176 1.00
545_L 577_L 2.174 1.00
620_A 628_K 2.148 1.00
330_Q 370_W 2.138 1.00
627_V 659_V 2.132 1.00
529_Q 553_D 2.124 1.00
53_V 134_E 2.119 1.00
629_L 659_V 2.115 1.00
641_L 650_E 2.111 1.00
410_V 459_L 2.082 1.00
166_G 190_T 2.072 1.00
249_H 285_W 2.068 1.00
166_G 663_F 2.065 1.00
377_A 403_N 2.06 1.00
414_W 455_W 2.049 1.00
131_E 158_K 2.044 1.00
171_D 658_A 2.02 1.00
167_T 662_R 2.016 1.00
633_V 636_L 2.015 1.00
457_L 477_V 2.005 1.00
485_R 526_A 1.991 1.00
57_E 61_R 1.991 1.00
205_G 235_R 1.976 1.00
207_L 235_R 1.972 1.00
475_V 531_V 1.972 1.00
633_V 655_Y 1.969 1.00
66_N 69_D 1.953 1.00
336_G 364_L 1.952 1.00
587_W 621_W 1.949 1.00
548_N 574_N 1.942 1.00
134_E 154_N 1.937 1.00
622_Q 628_K 1.929 1.00
451_T 484_D 1.918 1.00
401_V 409_T 1.911 1.00
76_G 550_T 1.911 1.00
405_T 408_V 1.897 1.00
628_K 660_D 1.896 1.00
411_K 476_T 1.889 1.00
478_F 550_T 1.875 1.00
543_W 579_W 1.866 1.00
474_S 534_E 1.862 1.00
623_V 629_L 1.855 1.00
411_K 458_G 1.848 1.00
104_D 240_E 1.845 1.00
201_M 241_F 1.84 1.00
455_W 481_D 1.833 1.00
169_T 187_Q 1.831 1.00
373_F 376_L 1.831 1.00
396_P 416_T 1.823 1.00
412_G 457_L 1.817 1.00
192_G 201_M 1.796 1.00
416_T 451_T 1.796 1.00
448_K 484_D 1.795 1.00
103_V 157_T 1.794 1.00
589_F 619_A 1.779 1.00
631_A 657_M 1.778 1.00
199_L 241_F 1.775 1.00
616_N 634_L 1.77 1.00
337_E 363_A 1.769 1.00
103_V 108_V 1.768 1.00
363_A 383_R 1.766 1.00
385_D 395_S 1.766 1.00
544_K 578_D 1.755 1.00
363_A 385_D 1.752 1.00
131_E 159_K 1.751 1.00
399_Y 413_G 1.741 1.00
92_R 532_E 1.73 1.00
547_I 575_G 1.729 1.00
417_A 452_S 1.7 1.00
633_V 653_R 1.683 1.00
170_V 186_G 1.68 1.00
540_N 543_W 1.679 1.00
198_V 243_W 1.679 1.00
576_T 592_S 1.678 1.00
91_I 151_G 1.672 1.00
591_V 617_T 1.656 1.00
477_V 529_Q 1.652 1.00
43_N 46_D 1.646 1.00
77_V 91_I 1.645 1.00
52_S 137_R 1.639 1.00
404_A 459_L 1.635 1.00
340_H 358_S 1.623 1.00
245_P 251_F 1.622 1.00
331_F 371_R 1.621 1.00
59_L 70_V 1.617 1.00
393_H 451_T 1.61 1.00
371_R 377_A 1.597 1.00
472_E 536_K 1.583 1.00
375_P 404_A 1.581 1.00
481_D 527_R 1.577 1.00
169_T 658_A 1.575 1.00
57_E 60_Q 1.565 1.00
629_L 657_M 1.548 1.00
473_S 533_T 1.545 1.00
200_G 242_A 1.539 1.00
594_H 614_I 1.539 1.00
104_D 157_T 1.536 1.00
167_T 660_D 1.532 1.00
477_V 531_V 1.526 1.00
249_H 281_H 1.526 1.00
539_F 577_L 1.523 1.00
596_T 612_Y 1.519 1.00
62_K 73_E 1.519 1.00
338_W 360_S 1.515 1.00
201_M 239_V 1.503 1.00
334_V 366_V 1.498 1.00
372_I 400_L 1.488 1.00
419_K 425_Q 1.486 1.00
481_D 525_K 1.478 1.00
372_I 378_L 1.478 1.00
471_V 535_L 1.464 1.00
419_K 450_E 1.461 1.00
46_D 403_N 1.451 1.00
188_F 205_G 1.445 1.00
622_Q 662_R 1.443 1.00
396_P 400_L 1.443 1.00
137_R 532_E 1.443 1.00
628_K 662_R 1.439 1.00
203_A 237_G 1.434 1.00
478_F 530_G 1.434 1.00
92_R 456_E 1.434 1.00
549_Y 573_A 1.431 1.00
412_G 455_W 1.426 1.00
578_D 590_Y 1.426 1.00
201_M 205_G 1.425 1.00
459_L 475_V 1.411 1.00
69_D 72_K 1.41 1.00
614_I 641_L 1.408 1.00
242_A 250_D 1.408 1.00
162_Q 200_G 1.403 0.99
587_W 619_A 1.397 0.99
451_T 483_K 1.395 0.99
634_L 654_R 1.393 0.99
552_N 568_L 1.391 0.99
386_D 392_E 1.385 0.99
623_V 627_V 1.381 0.99
331_F 369_E 1.378 0.99
161_G 191_S 1.376 0.99
454_S 480_N 1.373 0.99
135_V 153_V 1.367 0.99
526_A 565_L 1.367 0.99
367_E 379_T 1.344 0.99
461_Y 473_S 1.343 0.99
168_V 661_Y 1.333 0.99
615_W 636_L 1.333 0.99
325_L 328_I 1.332 0.99
332_L 368_D 1.328 0.99
610_G 639_K 1.325 0.99
487_S 523_V 1.323 0.99
142_S 381_G 1.317 0.99
618_G 630_R 1.317 0.99
544_K 580_K 1.31 0.99
404_A 408_V 1.298 0.99
410_V 457_L 1.296 0.99
531_V 551_Y 1.293 0.99
614_I 650_E 1.292 0.99
573_A 595_Y 1.291 0.99
411_K 460_Y 1.289 0.99
571_H 597_G 1.289 0.99
209_K 233_S 1.288 0.99
550_T 572_T 1.285 0.99
164_W 190_T 1.279 0.99
242_A 252_T 1.276 0.99
205_G 237_G 1.272 0.99
369_E 377_A 1.27 0.99
75_P 548_N 1.267 0.99
450_E 482_V 1.265 0.99
551_Y 570_F 1.264 0.99
144_Y 152_V 1.258 0.99
370_W 380_T 1.249 0.99
251_F 283_G 1.247 0.99
378_L 398_A 1.245 0.98
455_W 479_R 1.237 0.98
30_G 33_M 1.232 0.98
58_D 61_R 1.231 0.98
206_S 236_D 1.228 0.98
244_T 250_D 1.226 0.98
578_D 588_S 1.225 0.98
403_N 409_T 1.215 0.98
400_L 404_A 1.215 0.98
362_Y 386_D 1.213 0.98
89_V 153_V 1.213 0.98
165_S 191_S 1.213 0.98
126_P 129_S 1.213 0.98
38_S 42_Q 1.209 0.98
564_P 570_F 1.201 0.98
535_L 547_I 1.201 0.98
159_K 240_E 1.2 0.98
600_R 608_T 1.198 0.98
586_D 621_W 1.179 0.98
528_I 554_G 1.175 0.98
134_E 156_I 1.175 0.98
167_T 189_F 1.166 0.97
619_A 633_V 1.164 0.97
489_S 521_Y 1.163 0.97
617_T 633_V 1.16 0.97
161_G 165_S 1.16 0.97
67_L 155_I 1.16 0.97
249_H 283_G 1.156 0.97
626_D 661_Y 1.152 0.97
259_R 275_Q 1.152 0.97
536_K 544_K 1.145 0.97
591_V 636_L 1.137 0.97
627_V 631_A 1.137 0.97
659_V 663_F 1.13 0.97
630_R 660_D 1.13 0.97
172_T 657_M 1.124 0.97
104_D 254_G 1.119 0.96
164_W 192_G 1.111 0.96
460_Y 474_S 1.106 0.96
377_A 401_V 1.105 0.96
56_Q 131_E 1.104 0.96
447_L 486_I 1.102 0.96
91_I 135_V 1.099 0.96
164_W 193_P 1.098 0.96
638_D 652_G 1.093 0.96
61_R 578_D 1.09 0.96
364_L 384_M 1.089 0.96
538_P 544_K 1.088 0.96
172_T 176_E 1.087 0.96
456_E 476_T 1.087 0.96
94_L 482_V 1.083 0.96
613_T 639_K 1.078 0.95
602_D 605_T 1.077 0.95
478_F 532_E 1.077 0.95
539_F 545_L 1.074 0.95
54_I 74_V 1.074 0.95
328_I 370_W 1.073 0.95
102_L 152_V 1.067 0.95
53_V 132_R 1.064 0.95
105_G 154_N 1.063 0.95
545_L 575_G 1.063 0.95
636_L 653_R 1.061 0.95
149_L 452_S 1.059 0.95
407_T 461_Y 1.059 0.95
581_P 584_L 1.055 0.95
171_D 185_N 1.053 0.95
74_V 77_V 1.051 0.94
450_E 485_R 1.049 0.94
64_V 70_V 1.044 0.94
588_S 622_Q 1.039 0.94
657_M 661_Y 1.036 0.94
547_I 573_A 1.035 0.94
452_S 480_N 1.035 0.94
400_L 412_G 1.034 0.94
52_S 534_E 1.032 0.94
380_T 400_L 1.032 0.94
624_T 627_V 1.029 0.94
245_P 249_H 1.026 0.94
369_E 379_T 1.026 0.94
100_L 107_R 1.023 0.93
166_G 170_V 1.02 0.93
136_V 152_V 1.015 0.93
382_V 396_P 1.013 0.93
408_V 412_G 1.008 0.93
634_L 656_F 1.008 0.93
581_P 589_F 1.006 0.93
237_G 257_F 1.004 0.93
554_G 568_L 1.003 0.93
75_P 534_E 1.001 0.92
563_K 605_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hdiA10.96081000.163Contact Map0.793
4epaA10.88081000.245Contact Map0.737
2gufA10.85821000.253Contact Map0.771
3efmA10.89741000.263Contact Map0.806
1xkwA10.86431000.264Contact Map0.784
3qlbA20.89291000.265Contact Map0.79
3fhhA10.88841000.266Contact Map0.724
1qfgA10.88241000.267Contact Map0.748
4b7oA10.92461000.269Contact Map0.737
1fepA10.92311000.271Contact Map0.778

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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