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CHBR - HTH-type transcriptional regulator ChbR
UniProt: P17410 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10143
Length: 280 (240)
Sequences: 12061
Seq/Len: 50.25

CHBR
Paralog alert: 0.74 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
227_I 264_T 3.414 1.00
193_E 203_Q 3.162 1.00
239_Y 247_E 3.139 1.00
216_K 224_E 3.128 1.00
180_K 184_K 3.099 1.00
184_K 189_E 3.098 1.00
231_K 264_T 2.902 1.00
182_H 225_I 2.842 1.00
229_F 232_K 2.839 1.00
260_F 271_Y 2.744 1.00
233_Q 247_E 2.414 1.00
230_A 256_F 2.413 1.00
224_E 263_L 2.392 1.00
181_M 222_I 2.378 1.00
210_T 221_I 2.259 1.00
191_A 194_N 2.258 1.00
56_F 63_R 2.152 1.00
233_Q 239_Y 2.083 1.00
239_Y 243_D 2.068 1.00
54_R 65_L 2.063 1.00
234_L 241_V 2.041 1.00
227_I 263_L 2.037 1.00
240_S 243_D 1.973 1.00
177_T 206_L 1.952 1.00
56_F 65_L 1.939 1.00
233_Q 248_A 1.924 1.00
187_F 225_I 1.901 1.00
181_M 225_I 1.891 1.00
229_F 233_Q 1.867 1.00
45_Y 76_L 1.864 1.00
180_K 198_L 1.837 1.00
201_K 206_L 1.814 1.00
174_L 214_Y 1.756 1.00
58_E 63_R 1.748 1.00
269_K 273_K 1.743 1.00
219_M 223_N 1.739 1.00
266_F 274_K 1.72 1.00
67_E 70_D 1.706 1.00
192_L 207_T 1.699 1.00
179_E 183_D 1.692 1.00
54_R 67_E 1.684 1.00
242_T 253_P 1.677 1.00
195_M 218_P 1.67 1.00
177_T 199_S 1.663 1.00
243_D 247_E 1.623 1.00
52_T 90_R 1.6 1.00
231_K 271_Y 1.597 1.00
182_H 221_I 1.587 1.00
205_Y 209_A 1.559 1.00
178_V 214_Y 1.555 1.00
230_A 248_A 1.553 1.00
51_L 92_L 1.516 1.00
257_I 267_T 1.504 1.00
189_E 194_N 1.503 1.00
205_Y 208_R 1.489 1.00
266_F 270_S 1.473 1.00
201_K 205_Y 1.472 1.00
243_D 246_F 1.468 1.00
42_H 80_H 1.459 1.00
217_T 220_Q 1.456 1.00
193_E 197_A 1.448 1.00
203_Q 207_T 1.437 1.00
60_N 78_S 1.422 1.00
237_T 272_R 1.422 1.00
232_K 236_M 1.42 1.00
177_T 195_M 1.413 1.00
206_L 218_P 1.412 1.00
242_T 246_F 1.412 1.00
218_P 222_I 1.391 0.99
216_K 220_Q 1.389 0.99
204_E 208_R 1.389 0.99
184_K 188_S 1.375 0.99
56_F 83_F 1.375 0.99
244_I 248_A 1.361 0.99
229_F 248_A 1.354 0.99
58_E 81_Q 1.344 0.99
187_F 229_F 1.341 0.99
259_T 262_K 1.328 0.99
253_P 257_I 1.327 0.99
255_L 259_T 1.323 0.99
150_V 153_Y 1.306 0.99
194_N 198_L 1.3 0.99
257_I 269_K 1.291 0.99
254_S 257_I 1.281 0.99
180_K 195_M 1.277 0.99
267_T 270_S 1.255 0.99
250_Y 259_T 1.25 0.99
52_T 68_R 1.241 0.98
126_L 130_E 1.236 0.98
239_Y 244_I 1.227 0.98
225_I 229_F 1.226 0.98
195_M 198_L 1.219 0.98
226_R 248_A 1.199 0.98
75_P 78_S 1.199 0.98
184_K 187_F 1.199 0.98
252_S 258_K 1.183 0.98
241_V 244_I 1.18 0.98
173_W 201_K 1.177 0.98
40_H 80_H 1.177 0.98
46_E 80_H 1.173 0.98
39_L 79_H 1.168 0.97
237_T 244_I 1.16 0.97
127_T 130_E 1.157 0.97
202_S 205_Y 1.152 0.97
178_V 182_H 1.15 0.97
192_L 218_P 1.124 0.97
224_E 228_N 1.123 0.97
146_F 153_Y 1.116 0.96
257_I 261_K 1.109 0.96
173_W 199_S 1.103 0.96
258_K 262_K 1.092 0.96
207_T 218_P 1.085 0.96
225_I 228_N 1.081 0.95
42_H 46_E 1.058 0.95
50_V 53_G 1.047 0.94
50_V 55_Y 1.037 0.94
264_T 271_Y 1.03 0.94
196_V 203_Q 1.012 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gbgA10.92141000.292Contact Map0.66
3oouA10.38211000.515Contact Map0.779
3mn2A20.3751000.516Contact Map0.764
3oioA10.499.90.519Contact Map0.784
1bl0A10.417999.90.52Contact Map0.737
2k9sA10.37599.90.524Contact Map0.537
3w6vA10.514399.90.528Contact Map0.764
3lsgA50.360799.90.529Contact Map0.87
3mklA20.499.90.531Contact Map0.812
1d5yA40.389399.90.536Contact Map0.705

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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