GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
CHBF - 6-phospho-beta-glucosidase
UniProt: P17411 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10144
Length: 450 (437)
Sequences: 716
Seq/Len: 1.64

CHBF
Paralog alert: 0.64 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: AGAL CHBF GLVG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
75_R 138_E 4.282 1.00
83_F 329_Y 3.322 1.00
74_R 135_D 3.056 1.00
78_L 140_C 2.996 1.00
406_L 425_A 2.735 1.00
108_Y 116_A 2.713 1.00
193_D 213_N 2.672 1.00
338_V 361_L 2.632 1.00
136_V 145_V 2.461 1.00
327_A 334_A 2.441 1.00
395_N 399_S 2.358 1.00
362_G 367_T 2.335 1.00
375_F 383_I 2.288 1.00
105_S 427_E 2.264 0.99
52_F 70_K 2.215 0.99
108_Y 424_L 2.176 0.99
137_E 163_T 2.155 0.99
136_V 165_F 2.138 0.99
186_L 221_L 2.132 0.99
209_D 216_S 2.122 0.99
402_F 426_R 2.096 0.99
347_D 374_H 2.086 0.99
76_E 79_K 2.079 0.99
217_R 220_E 2.078 0.99
338_V 359_C 2.068 0.99
119_L 393_A 2.031 0.99
35_E 67_K 2.027 0.99
21_L 36_L 1.992 0.98
134_K 137_E 1.985 0.98
49_D 53_D 1.975 0.98
106_H 423_L 1.964 0.98
35_E 69_Y 1.958 0.98
73_D 76_E 1.926 0.98
349_I 383_I 1.918 0.98
97_E 283_A 1.894 0.97
75_R 135_D 1.893 0.97
399_S 404_D 1.864 0.97
136_V 140_C 1.847 0.97
90_V 128_V 1.844 0.97
161_R 395_N 1.817 0.97
116_A 415_V 1.816 0.97
348_N 380_M 1.81 0.96
53_D 56_Q 1.781 0.96
52_F 56_Q 1.778 0.96
144_W 167_R 1.773 0.96
345_Q 355_V 1.757 0.96
223_D 227_S 1.755 0.96
331_D 363_R 1.754 0.96
133_V 159_V 1.722 0.95
80_D 142_N 1.721 0.95
405_V 425_A 1.715 0.95
292_Q 308_E 1.674 0.94
131_D 134_K 1.67 0.94
204_M 386_I 1.663 0.94
430_L 433_E 1.659 0.93
142_N 167_R 1.653 0.93
212_I 217_R 1.651 0.93
295_E 298_K 1.607 0.92
380_M 384_H 1.583 0.91
409_L 428_M 1.58 0.91
347_D 351_A 1.57 0.91
119_L 389_F 1.547 0.90
109_L 269_L 1.538 0.89
127_P 397_A 1.536 0.89
102_I 431_A 1.535 0.89
37_W 71_T 1.525 0.89
101_R 284_Q 1.519 0.89
333_Q 362_G 1.511 0.88
6_K 37_W 1.509 0.88
276_Y 287_Q 1.497 0.88
125_T 128_V 1.492 0.87
377_D 388_G 1.487 0.87
340_I 361_L 1.468 0.86
42_E 92_Q 1.468 0.86
43_G 49_D 1.463 0.86
114_N 386_I 1.451 0.85
190_D 193_D 1.439 0.85
362_G 366_A 1.434 0.85
126_I 158_A 1.427 0.84
206_F 263_F 1.417 0.84
159_V 168_F 1.413 0.83
45_K 49_D 1.402 0.83
169_I 366_A 1.387 0.82
137_E 164_G 1.351 0.79
195_S 211_L 1.344 0.79
13_G 40_D 1.342 0.79
215_K 220_E 1.34 0.79
179_K 191_S 1.335 0.78
404_D 407_L 1.332 0.78
343_H 351_A 1.328 0.78
8_V 81_A 1.313 0.77
153_G 390_E 1.303 0.76
83_F 328_I 1.299 0.76
326_N 330_N 1.294 0.75
282_R 317_Y 1.294 0.75
23_G 173_N 1.291 0.75
328_I 331_D 1.289 0.75
84_V 136_V 1.266 0.73
362_G 365_G 1.264 0.73
37_W 69_Y 1.262 0.73
9_T 85_T 1.261 0.72
424_L 428_M 1.259 0.72
335_E 358_T 1.255 0.72
42_E 45_K 1.252 0.72
162_H 398_L 1.251 0.72
120_F 140_C 1.246 0.71
89_R 96_R 1.23 0.70
160_Y 341_P 1.224 0.69
30_E 326_N 1.219 0.69
84_V 143_A 1.215 0.68
96_R 100_E 1.215 0.68
49_D 70_K 1.211 0.68
246_G 422_E 1.21 0.68
348_N 373_T 1.201 0.67
340_I 359_C 1.198 0.67
220_E 223_D 1.187 0.66
79_K 139_L 1.186 0.66
193_D 212_I 1.184 0.65
119_L 405_V 1.183 0.65
401_E 404_D 1.173 0.64
389_F 409_L 1.171 0.64
360_K 369_H 1.165 0.64
261_Y 382_L 1.159 0.63
30_E 332_K 1.157 0.63
8_V 78_L 1.157 0.63
274_G 277_Y 1.156 0.63
424_L 427_E 1.15 0.62
118_G 124_R 1.149 0.62
120_F 429_I 1.144 0.62
6_K 35_E 1.143 0.61
268_M 417_S 1.137 0.61
307_K 310_E 1.135 0.61
35_E 38_L 1.132 0.60
103_P 117_G 1.131 0.60
375_F 380_M 1.13 0.60
146_I 325_I 1.122 0.59
156_T 160_Y 1.118 0.59
220_E 224_G 1.116 0.59
347_D 371_R 1.115 0.59
426_R 429_I 1.11 0.58
142_N 190_D 1.108 0.58
89_R 100_E 1.108 0.58
148_F 153_G 1.105 0.58
326_N 332_K 1.102 0.57
106_H 427_E 1.102 0.57
72_L 76_E 1.101 0.57
335_E 360_K 1.095 0.57
130_F 158_A 1.093 0.56
228_G 231_K 1.088 0.56
429_I 433_E 1.084 0.55
395_N 404_D 1.083 0.55
345_Q 357_M 1.083 0.55
221_L 254_L 1.071 0.54
56_Q 76_E 1.067 0.54
346_I 355_V 1.067 0.54
218_F 222_L 1.065 0.53
75_R 139_L 1.063 0.53
20_L 87_Q 1.059 0.53
34_S 67_K 1.057 0.53
359_C 368_P 1.054 0.52
122_G 354_A 1.05 0.52
116_A 409_L 1.05 0.52
113_T 262_Y 1.05 0.52
134_K 187_M 1.049 0.52
18_P 112_E 1.047 0.52
152_A 175_P 1.046 0.51
404_D 410_N 1.045 0.51
419_R 423_L 1.042 0.51
198_L 205_V 1.035 0.50
106_H 424_L 1.028 0.49
99_D 124_R 1.026 0.49
100_E 110_G 1.025 0.49
10_I 145_V 1.023 0.49
134_K 162_H 1.023 0.49
182_I 207_I 1.019 0.49
283_A 286_V 1.018 0.48
125_T 397_A 1.017 0.48
343_H 354_A 1.014 0.48
360_K 367_T 1.007 0.47
46_P 222_L 1.006 0.47
56_Q 60_D 1.005 0.47
299_N 306_P 1.003 0.47
79_K 134_K 1.001 0.47
48_L 70_K 1 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1s6yA10.99331000.335Contact Map0.726
1up7A80.92441000.358Contact Map0.718
1u8xX10.96891000.363Contact Map0.631
1obbA20.96671000.369Contact Map0.591
3u95A60.961000.428Contact Map0.619
3fefA40.93781000.433Contact Map0.643
1pzgA40.70891000.729Contact Map0.618
3gviA60.69781000.735Contact Map0.625
1t2dA10.69111000.738Contact Map0.656
3p7mA40.68441000.739Contact Map0.635

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.041 seconds.