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BETA - Choline dehydrogenase
UniProt: P17444 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10109
Length: 556 (532)
Sequences: 4842
Seq/Len: 9.10

BETA
Paralog alert: 0.46 [within 20: 0.09] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
225_I 232_A 3.947 1.00
489_D 493_R 3.658 1.00
117_S 120_D 3.612 1.00
481_G 486_S 3.276 1.00
275_A 279_A 3.275 1.00
224_H 236_E 3.152 1.00
505_A 520_T 3.099 1.00
429_R 457_D 3.075 1.00
237_W 248_A 3.051 1.00
503_V 527_I 3.031 1.00
263_S 478_C 3.018 1.00
392_P 417_H 3.004 1.00
403_D 406_Q 2.975 1.00
124_Y 529_D 2.909 1.00
167_Q 439_A 2.885 1.00
130_T 142_D 2.842 1.00
12_S 89_S 2.817 1.00
265_Q 269_R 2.774 1.00
7_I 17_L 2.694 1.00
277_L 280_E 2.676 1.00
425_R 461_D 2.631 1.00
121_C 522_M 2.605 1.00
275_A 288_E 2.595 1.00
456_T 459_Q 2.557 1.00
108_A 117_S 2.527 1.00
36_G 219_H 2.516 1.00
226_I 236_E 2.474 1.00
234_G 254_V 2.452 1.00
253_E 501_R 2.449 1.00
268_Q 399_I 2.434 1.00
491_E 534_Q 2.407 1.00
520_T 524_G 2.407 1.00
401_S 406_Q 2.37 1.00
236_E 243_T 2.344 1.00
488_V 507_I 2.34 1.00
6_I 248_A 2.335 1.00
478_C 506_S 2.333 1.00
432_R 447_E 2.319 1.00
101_A 119_L 2.301 1.00
222_T 266_I 2.3 1.00
274_N 288_E 2.255 1.00
294_E 396_H 2.206 1.00
268_Q 277_L 2.175 1.00
447_E 451_G 2.157 1.00
494_V 500_L 2.153 1.00
69_E 411_L 2.149 1.00
492_G 527_I 2.148 1.00
32_L 220_A 2.142 1.00
491_E 533_G 2.123 1.00
236_E 247_R 2.11 1.00
268_Q 398_R 2.109 1.00
227_F 272_V 2.084 1.00
231_R 499_G 2.082 1.00
508_M 523_I 2.065 1.00
85_L 216_I 2.055 1.00
392_P 419_Q 2.051 1.00
294_E 398_R 2.04 1.00
217_R 220_A 2.024 1.00
277_L 399_I 2.018 1.00
503_V 524_G 2.011 1.00
526_K 530_M 2.01 1.00
64_Y 262_A 2.007 1.00
418_E 422_Q 1.982 1.00
22_T 211_R 1.982 1.00
23_E 532_R 1.978 1.00
82_G 88_S 1.97 1.00
3_F 30_L 1.947 1.00
478_C 487_V 1.937 1.00
84_G 90_L 1.925 1.00
19_T 23_E 1.91 1.00
3_F 215_T 1.897 1.00
277_L 281_F 1.869 1.00
227_F 230_K 1.863 1.00
223_D 236_E 1.859 1.00
400_K 406_Q 1.841 1.00
8_I 225_I 1.835 1.00
163_E 166_V 1.831 1.00
462_E 466_N 1.814 1.00
277_L 294_E 1.811 1.00
85_L 218_T 1.795 1.00
115_N 120_D 1.783 1.00
291_G 485_M 1.78 1.00
261_I 397_V 1.777 1.00
226_I 234_G 1.776 1.00
263_S 502_V 1.775 1.00
30_L 248_A 1.771 1.00
168_A 437_Q 1.769 1.00
20_R 525_E 1.761 1.00
428_I 460_L 1.758 1.00
32_L 237_W 1.757 1.00
220_A 237_W 1.757 1.00
32_L 235_V 1.755 1.00
96_Y 518_A 1.727 1.00
10_A 85_L 1.713 1.00
287_H 497_L 1.713 1.00
223_D 238_L 1.706 1.00
277_L 398_R 1.705 1.00
430_I 433_E 1.702 1.00
483_D 486_S 1.693 1.00
228_D 233_V 1.683 1.00
200_T 521_I 1.667 1.00
67_E 409_A 1.654 1.00
209_K 216_I 1.65 1.00
6_I 30_L 1.647 1.00
275_A 496_G 1.643 1.00
166_V 172_R 1.634 1.00
272_V 497_L 1.631 1.00
361_Q 515_N 1.628 1.00
99_G 104_L 1.627 1.00
307_E 446_R 1.625 1.00
12_S 517_N 1.617 1.00
124_Y 127_K 1.611 1.00
13_A 520_T 1.605 1.00
24_D 532_R 1.594 1.00
279_A 285_L 1.581 1.00
233_V 249_T 1.571 1.00
32_L 217_R 1.559 1.00
262_A 265_Q 1.555 1.00
2_Q 251_N 1.554 1.00
231_R 498_E 1.546 1.00
221_M 405_H 1.544 1.00
127_K 529_D 1.542 1.00
24_D 27_T 1.531 1.00
268_Q 294_E 1.523 1.00
69_E 412_F 1.522 1.00
2_Q 249_T 1.518 1.00
507_I 523_I 1.512 1.00
479_K 485_M 1.511 1.00
127_K 525_E 1.51 1.00
98_R 129_E 1.51 1.00
421_W 461_D 1.501 1.00
227_F 286_V 1.492 1.00
517_N 521_I 1.487 1.00
30_L 217_R 1.484 1.00
238_L 405_H 1.481 1.00
296_L 477_T 1.48 1.00
475_C 511_I 1.477 1.00
266_I 269_R 1.472 1.00
396_H 411_L 1.465 1.00
31_L 214_L 1.457 1.00
491_E 530_M 1.442 0.99
400_K 409_A 1.437 0.99
226_I 233_V 1.43 0.99
104_L 519_T 1.427 0.99
223_D 243_T 1.423 0.99
486_S 495_H 1.421 0.99
73_N 466_N 1.413 0.99
413_N 416_S 1.41 0.99
223_D 405_H 1.405 0.99
81_R 88_S 1.393 0.99
432_R 451_G 1.385 0.99
10_A 15_N 1.37 0.99
479_K 483_D 1.369 0.99
5_Y 27_T 1.368 0.99
455_Q 459_Q 1.359 0.99
28_S 251_N 1.357 0.99
204_Y 525_E 1.352 0.99
475_C 516_L 1.347 0.99
281_F 402_R 1.335 0.99
306_Y 435_M 1.331 0.99
441_D 444_R 1.328 0.99
128_A 521_I 1.325 0.99
527_I 531_I 1.323 0.99
106_N 510_Q 1.314 0.99
12_S 521_I 1.314 0.99
67_E 411_L 1.306 0.99
255_L 531_I 1.287 0.99
67_E 400_K 1.287 0.99
497_L 500_L 1.283 0.99
422_Q 426_D 1.274 0.98
226_I 247_R 1.273 0.98
17_L 524_G 1.272 0.98
235_V 254_V 1.271 0.98
268_Q 274_N 1.27 0.98
232_A 254_V 1.269 0.98
19_T 208_A 1.266 0.98
15_N 200_T 1.265 0.98
274_N 277_L 1.26 0.98
162_I 166_V 1.257 0.98
273_G 494_V 1.257 0.98
130_T 146_S 1.253 0.98
217_R 239_E 1.251 0.98
17_L 503_V 1.229 0.98
113_L 490_G 1.228 0.98
228_D 249_T 1.218 0.98
114_E 490_G 1.215 0.98
128_A 204_Y 1.211 0.98
458_E 461_D 1.207 0.98
122_L 126_R 1.203 0.98
37_P 209_K 1.202 0.98
230_K 498_E 1.195 0.97
492_G 507_I 1.193 0.97
176_L 185_G 1.188 0.97
473_H 515_N 1.179 0.97
516_L 520_T 1.175 0.97
7_I 18_A 1.173 0.97
274_N 294_E 1.168 0.97
34_A 62_W 1.164 0.97
268_Q 292_V 1.156 0.97
230_K 287_H 1.155 0.97
351_S 360_I 1.148 0.96
65_E 76_R 1.147 0.96
34_A 83_K 1.146 0.96
5_Y 255_L 1.145 0.96
3_F 6_I 1.144 0.96
275_A 285_L 1.139 0.96
260_A 264_P 1.138 0.96
22_T 29_V 1.135 0.96
27_T 532_R 1.135 0.96
426_D 429_R 1.131 0.96
258_A 262_A 1.126 0.96
198_A 203_G 1.12 0.96
79_C 261_I 1.114 0.96
226_I 249_T 1.114 0.96
38_D 90_L 1.114 0.96
422_Q 461_D 1.113 0.96
291_G 486_S 1.113 0.96
329_E 333_G 1.11 0.96
488_V 502_V 1.11 0.96
16_V 19_T 1.107 0.95
159_E 163_E 1.106 0.95
261_I 410_I 1.106 0.95
99_G 125_Y 1.104 0.95
7_I 19_T 1.104 0.95
274_N 398_R 1.098 0.95
285_L 288_E 1.096 0.95
88_S 91_I 1.093 0.95
289_L 495_H 1.092 0.95
66_T 79_C 1.088 0.95
516_L 519_T 1.074 0.94
81_R 265_Q 1.074 0.94
108_A 115_N 1.069 0.94
329_E 335_T 1.063 0.94
217_R 237_W 1.062 0.94
104_L 125_Y 1.06 0.94
129_E 139_H 1.052 0.94
28_S 213_N 1.052 0.94
15_N 31_L 1.051 0.93
97_I 514_G 1.05 0.93
140_G 143_G 1.049 0.93
255_L 503_V 1.047 0.93
425_R 464_V 1.046 0.93
198_A 202_R 1.046 0.93
479_K 486_S 1.045 0.93
292_V 487_V 1.044 0.93
526_K 529_D 1.042 0.93
118_Y 122_L 1.033 0.93
16_V 204_Y 1.03 0.93
145_V 203_G 1.029 0.93
438_P 442_Q 1.027 0.92
295_N 479_K 1.025 0.92
167_Q 437_Q 1.024 0.92
17_L 255_L 1.023 0.92
16_V 521_I 1.023 0.92
295_N 394_R 1.023 0.92
505_A 508_M 1.018 0.92
291_G 479_K 1.018 0.92
101_A 105_D 1.017 0.92
260_A 475_C 1.013 0.92
237_W 244_I 1.009 0.92
32_L 248_A 1.007 0.91
164_A 439_A 1.006 0.91
529_D 532_R 1.002 0.91
529_D 533_G 1.001 0.91
281_F 399_I 1.001 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fimB10.95321000.178Contact Map0.779
4h7uA10.94061000.188Contact Map0.764
1gpeA20.9461000.225Contact Map0.82
3qvpA10.9461000.227Contact Map0.805
3q9tA30.94421000.228Contact Map0.83
2jbvA20.93531000.237Contact Map0.82
4ha6A10.90111000.241Contact Map0.788
1ju2A20.88311000.338Contact Map0.773
1kdgA20.89571000.351Contact Map0.729
3pl8A10.89751000.413Contact Map0.573

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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