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BETB - Betaine aldehyde dehydrogenase
UniProt: P17445 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10110
Length: 490 (474)
Sequences: 17876
Seq/Len: 37.71

BETB
Paralog alert: 0.85 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
296_A 399_E 5.418 1.00
239_A 244_S 3.448 1.00
296_A 397_T 3.202 1.00
268_D 305_K 3.142 1.00
263_D 295_P 2.864 1.00
331_F 335_D 2.768 1.00
54_Q 221_G 2.763 1.00
378_S 381_M 2.76 1.00
80_R 114_E 2.743 1.00
25_E 37_T 2.733 1.00
299_K 397_T 2.726 1.00
356_D 370_A 2.679 1.00
342_A 346_E 2.653 1.00
263_D 297_K 2.599 1.00
343_K 382_T 2.57 1.00
272_D 309_R 2.551 1.00
187_K 190_E 2.539 1.00
82_R 85_E 2.529 1.00
303_E 395_I 2.488 1.00
12_H 55_Q 2.432 1.00
341_I 369_V 2.396 1.00
328_L 337_V 2.374 1.00
421_T 427_A 2.337 1.00
193_S 199_D 2.331 1.00
54_Q 223_A 2.262 1.00
429_R 433_Q 2.158 1.00
307_L 311_E 2.156 1.00
42_G 45_D 2.131 1.00
25_E 34_V 2.119 1.00
350_R 376_D 2.068 1.00
401_E 429_R 2.044 1.00
401_E 426_R 1.996 1.00
83_N 107_V 1.99 1.00
338_L 342_A 1.984 1.00
75_A 192_Y 1.978 1.00
374_F 383_I 1.972 1.00
78_I 194_E 1.956 1.00
9_L 41_A 1.955 1.00
343_K 347_E 1.929 1.00
71_I 197_L 1.921 1.00
293_F 404_V 1.915 1.00
51_K 221_G 1.907 1.00
304_Q 308_A 1.904 1.00
301_A 305_K 1.89 1.00
345_K 351_V 1.877 1.00
10_Y 193_S 1.867 1.00
77_D 81_E 1.849 1.00
292_V 393_M 1.848 1.00
180_V 330_S 1.846 1.00
338_L 357_V 1.845 1.00
259_L 274_A 1.839 1.00
141_E 477_K 1.825 1.00
352_L 375_T 1.824 1.00
78_I 81_E 1.821 1.00
412_D 458_H 1.809 1.00
140_R 474_T 1.803 1.00
78_I 191_I 1.797 1.00
113_L 164_A 1.785 1.00
214_Q 218_E 1.781 1.00
382_T 386_E 1.781 1.00
85_E 187_K 1.763 1.00
399_E 403_E 1.762 1.00
84_D 103_T 1.754 1.00
338_L 369_V 1.751 1.00
264_D 426_R 1.741 1.00
47_D 215_Y 1.736 1.00
403_E 406_R 1.724 1.00
218_E 240_N 1.723 1.00
57_Q 61_A 1.722 1.00
47_D 51_K 1.716 1.00
350_R 375_T 1.712 1.00
77_D 114_E 1.709 1.00
310_V 373_V 1.705 1.00
402_D 433_Q 1.696 1.00
300_A 397_T 1.695 1.00
235_K 458_H 1.681 1.00
293_F 407_R 1.663 1.00
435_E 457_K 1.653 1.00
263_D 426_R 1.652 1.00
307_L 352_L 1.644 1.00
351_V 374_F 1.628 1.00
299_K 303_E 1.621 1.00
84_D 88_K 1.616 1.00
189_A 204_V 1.61 1.00
417_A 436_A 1.594 1.00
89_L 187_K 1.588 1.00
78_I 195_A 1.587 1.00
172_A 201_V 1.585 1.00
379_D 407_R 1.579 1.00
73_R 114_E 1.574 1.00
236_K 239_A 1.57 1.00
295_P 398_Y 1.565 1.00
140_R 471_Q 1.561 1.00
14_G 199_D 1.553 1.00
301_A 304_Q 1.545 1.00
273_I 420_V 1.538 1.00
64_T 67_E 1.532 1.00
384_V 396_L 1.531 1.00
309_R 312_R 1.529 1.00
74_R 77_D 1.513 1.00
295_P 400_S 1.499 1.00
274_A 302_F 1.494 1.00
8_Q 17_S 1.487 1.00
80_R 110_A 1.482 1.00
267_L 305_K 1.479 1.00
82_R 194_E 1.475 1.00
405_I 430_V 1.467 1.00
314_R 322_Q 1.451 1.00
335_D 339_R 1.449 1.00
305_K 308_A 1.448 1.00
47_D 219_H 1.448 1.00
349_A 374_F 1.436 1.00
67_E 70_R 1.428 1.00
294_V 302_F 1.427 1.00
62_S 433_Q 1.425 1.00
339_R 382_T 1.424 1.00
342_A 345_K 1.421 1.00
400_S 403_E 1.415 1.00
262_F 426_R 1.406 0.99
57_Q 172_A 1.395 0.99
88_K 92_L 1.383 0.99
27_I 34_V 1.383 0.99
34_V 37_T 1.356 0.99
308_A 312_R 1.356 0.99
279_F 310_V 1.344 0.99
331_F 367_A 1.338 0.99
274_A 292_V 1.331 0.99
148_G 173_M 1.331 0.99
88_K 319_F 1.329 0.99
76_V 114_E 1.329 0.99
86_L 187_K 1.327 0.99
50_V 219_H 1.326 0.99
271_A 305_K 1.32 0.99
16_T 48_R 1.319 0.99
347_E 382_T 1.315 0.99
33_N 365_N 1.313 0.99
299_K 375_T 1.311 0.99
139_R 432_H 1.31 0.99
308_A 311_E 1.296 0.99
403_E 407_R 1.294 0.99
262_F 398_Y 1.294 0.99
28_N 31_N 1.283 0.99
51_K 55_Q 1.28 0.99
340_Y 388_I 1.277 0.99
313_I 325_F 1.277 0.99
317_D 320_D 1.275 0.99
334_R 338_L 1.272 0.99
113_L 160_L 1.271 0.99
192_Y 202_F 1.27 0.99
46_V 212_T 1.27 0.99
311_E 353_C 1.264 0.99
334_R 369_V 1.262 0.99
91_T 101_T 1.261 0.99
238_M 461_I 1.259 0.99
344_G 374_F 1.249 0.99
75_A 191_I 1.248 0.99
190_E 194_E 1.246 0.98
119_L 122_A 1.243 0.98
402_D 429_R 1.241 0.98
74_R 78_I 1.233 0.98
224_K 250_T 1.232 0.98
45_D 48_R 1.231 0.98
63_M 67_E 1.225 0.98
259_L 289_G 1.221 0.98
75_A 113_L 1.221 0.98
398_Y 407_R 1.217 0.98
82_R 191_I 1.198 0.98
293_F 398_Y 1.196 0.98
331_F 334_R 1.187 0.98
159_A 175_F 1.186 0.98
262_F 430_V 1.185 0.98
76_V 80_R 1.184 0.98
337_V 390_G 1.176 0.98
385_R 410_D 1.175 0.98
189_A 202_F 1.175 0.98
86_L 191_I 1.166 0.97
148_G 226_S 1.166 0.97
82_R 187_K 1.165 0.97
431_I 479_I 1.165 0.97
126_S 467_V 1.165 0.97
139_R 479_I 1.16 0.97
468_M 471_Q 1.158 0.97
28_N 317_D 1.153 0.97
36_A 183_L 1.151 0.97
405_I 433_Q 1.151 0.97
10_Y 15_Y 1.149 0.97
50_V 221_G 1.148 0.97
385_R 412_D 1.141 0.97
405_I 409_N 1.139 0.97
260_I 404_V 1.135 0.97
23_T 37_T 1.134 0.97
417_A 439_C 1.132 0.97
98_Y 103_T 1.121 0.97
126_S 468_M 1.12 0.96
380_D 385_R 1.118 0.96
140_R 476_V 1.112 0.96
163_S 202_F 1.111 0.96
300_A 304_Q 1.108 0.96
302_F 306_I 1.103 0.96
345_K 374_F 1.103 0.96
214_Q 240_N 1.1 0.96
334_R 357_V 1.099 0.96
214_Q 236_K 1.097 0.96
52_S 200_G 1.097 0.96
303_E 307_L 1.096 0.96
233_S 236_K 1.089 0.96
306_I 393_M 1.083 0.96
404_V 407_R 1.08 0.95
298_C 301_A 1.078 0.95
32_G 367_A 1.076 0.95
379_D 410_D 1.071 0.95
91_T 318_V 1.069 0.95
303_E 352_L 1.065 0.95
83_N 103_T 1.064 0.95
295_P 298_C 1.063 0.95
63_M 71_I 1.061 0.95
402_D 406_R 1.06 0.95
236_K 240_N 1.06 0.95
137_Y 428_H 1.059 0.95
401_E 430_V 1.057 0.95
260_I 430_V 1.056 0.95
32_G 365_N 1.056 0.95
75_A 197_L 1.052 0.95
427_A 441_I 1.049 0.94
137_Y 481_V 1.047 0.94
467_V 471_Q 1.041 0.94
262_F 295_P 1.04 0.94
423_D 426_R 1.04 0.94
238_M 249_V 1.039 0.94
147_A 222_I 1.036 0.94
230_G 233_S 1.036 0.94
307_L 353_C 1.035 0.94
143_L 171_N 1.034 0.94
235_K 246_L 1.034 0.94
145_V 222_I 1.031 0.94
311_E 370_A 1.029 0.94
22_R 40_A 1.028 0.94
58_K 406_R 1.027 0.94
154_Y 285_V 1.027 0.94
258_P 417_A 1.02 0.93
223_A 435_E 1.019 0.93
20_S 42_G 1.015 0.93
300_A 303_E 1.013 0.93
314_R 324_N 1.012 0.93
406_R 410_D 1.009 0.93
354_G 372_T 1.008 0.93
264_D 423_D 1.005 0.93
269_L 422_A 1.003 0.93
88_K 98_Y 1.002 0.92
303_E 375_T 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1o04A80.98571000.038Contact Map0.826
1a4sA40.99391000.038Contact Map0.793
1bxsA40.98371000.038Contact Map0.83
4i8pA20.99181000.038Contact Map0.784
4f3xA40.97351000.041Contact Map0.73
3ed6A20.99591000.045Contact Map0.788
4i9bA20.99181000.045Contact Map0.759
3ek1A80.97351000.046Contact Map0.806
2o2pA40.97551000.046Contact Map0.819
3u4jA40.98981000.046Contact Map0.809

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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