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BETI - HTH-type transcriptional regulator BetI
UniProt: P17446 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10111
Length: 195 (187)
Sequences: 18458
Seq/Len: 98.71

BETI
Paralog alert: 0.77 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: ACRR BDCR BETI COMR ENVR NEMR RUTR SLMA UIDR YBIH YBJK YJDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
25_V 34_Q 4.141 1.00
20_E 38_R 3.68 1.00
33_A 43_T 3.587 1.00
51_R 55_G 2.889 1.00
12_R 63_D 2.418 1.00
24_E 38_R 2.371 1.00
22_I 30_A 2.293 1.00
21_A 30_A 2.237 1.00
10_R 13_Q 2.227 1.00
42_S 45_I 2.147 1.00
83_S 86_Q 2.147 1.00
52_D 55_G 2.119 1.00
17_A 38_R 2.063 1.00
11_R 59_A 2.011 1.00
36_A 46_I 1.99 1.00
33_A 37_R 1.947 1.00
138_V 142_R 1.94 1.00
21_A 38_R 1.93 1.00
18_T 22_I 1.906 1.00
12_R 16_D 1.895 1.00
93_G 181_N 1.825 1.00
59_A 62_R 1.82 1.00
19_L 63_D 1.763 1.00
62_R 125_L 1.758 1.00
13_Q 17_A 1.758 1.00
89_Q 185_R 1.75 1.00
22_I 27_M 1.705 1.00
21_A 25_V 1.667 1.00
15_I 59_A 1.666 1.00
21_A 34_Q 1.649 1.00
16_D 63_D 1.641 1.00
134_L 151_Q 1.592 1.00
26_G 29_D 1.529 1.00
32_I 46_I 1.528 1.00
55_G 59_A 1.523 1.00
20_E 24_E 1.492 1.00
32_I 47_S 1.49 1.00
50_F 59_A 1.474 1.00
176_D 179_R 1.473 1.00
30_A 35_I 1.471 1.00
18_T 56_L 1.463 1.00
27_M 57_L 1.439 1.00
17_A 20_E 1.421 1.00
34_Q 37_R 1.407 0.99
54_N 119_Q 1.405 0.99
26_G 30_A 1.392 0.99
63_D 67_Q 1.392 0.99
87_R 139_S 1.377 0.99
34_Q 38_R 1.371 0.99
83_S 144_E 1.36 0.99
32_I 43_T 1.357 0.99
159_A 163_G 1.339 0.99
156_G 160_L 1.337 0.99
35_I 56_L 1.332 0.99
31_T 34_Q 1.309 0.99
15_I 60_T 1.292 0.99
138_V 150_A 1.284 0.99
136_N 140_E 1.268 0.99
11_R 49_Y 1.267 0.99
19_L 60_T 1.257 0.99
17_A 39_A 1.244 0.98
139_S 143_R 1.243 0.98
47_S 52_D 1.241 0.98
89_Q 93_G 1.237 0.98
15_I 50_F 1.226 0.98
85_E 189_T 1.223 0.98
45_I 49_Y 1.217 0.98
149_Q 152_E 1.201 0.98
138_V 151_Q 1.201 0.98
41_V 45_I 1.192 0.98
19_L 64_I 1.183 0.98
124_R 128_V 1.18 0.98
62_R 66_S 1.173 0.98
87_R 140_E 1.173 0.98
9_I 12_R 1.167 0.97
86_Q 90_A 1.163 0.97
19_L 23_N 1.151 0.97
55_G 58_E 1.136 0.97
25_V 29_D 1.132 0.97
10_R 49_Y 1.13 0.97
90_A 93_G 1.129 0.97
17_A 21_A 1.114 0.96
45_I 48_H 1.107 0.96
16_D 20_E 1.106 0.96
135_S 139_S 1.1 0.96
58_E 62_R 1.098 0.96
78_A 81_Q 1.083 0.96
134_L 138_V 1.082 0.96
134_L 155_Y 1.062 0.95
138_V 141_F 1.057 0.95
140_E 145_L 1.055 0.95
71_A 94_G 1.055 0.95
9_I 13_Q 1.05 0.94
54_N 58_E 1.029 0.94
20_E 104_A 1.025 0.93
54_N 121_M 1.018 0.93
59_A 63_D 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2np5A40.97951000.149Contact Map0.75
2gfnA20.98971000.15Contact Map0.76
2nx4A40.96411000.158Contact Map0.772
1ui5A20.98971000.165Contact Map0.735
2iaiA10.98971000.166Contact Map0.613
3crjA40.969299.90.178Contact Map0.788
2dg8A40.948799.90.178Contact Map0.791
3ppbA20.984699.90.18Contact Map0.695
2xdnA40.994999.90.182Contact Map0.72
2genA10.969299.90.183Contact Map0.643

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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