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CYNX - Cyanate transport protein CynX
UniProt: P17583 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10177
Length: 384 (370)
Sequences: 64214
Seq/Len: 173.55

CYNX
Paralog alert: 0.90 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
86_P 90_L 4.196 1.00
74_L 101_G 3.564 1.00
81_M 94_S 3.543 1.00
83_E 158_A 3.243 1.00
47_T 96_L 3.085 1.00
76_A 164_A 2.956 1.00
78_G 94_S 2.922 1.00
64_E 115_R 2.911 1.00
89_A 93_S 2.783 1.00
55_G 104_I 2.76 1.00
87_Q 90_L 2.734 1.00
88_S 92_L 2.502 1.00
229_S 232_Y 2.477 1.00
117_F 124_V 2.418 1.00
71_S 104_I 2.417 1.00
120_R 123_L 2.382 1.00
33_S 36_V 2.38 1.00
78_G 101_G 2.355 1.00
78_G 97_L 2.286 1.00
51_L 100_V 2.248 1.00
122_P 256_R 2.223 1.00
243_G 291_M 2.082 1.00
65_R 69_A 2.031 1.00
247_G 295_L 2.01 1.00
210_G 336_A 1.997 1.00
85_Y 90_L 1.99 1.00
85_Y 94_S 1.981 1.00
51_L 103_G 1.966 1.00
260_R 310_D 1.945 1.00
80_L 161_A 1.907 1.00
40_L 91_L 1.89 1.00
174_Q 177_R 1.882 1.00
36_V 88_S 1.841 1.00
277_G 289_W 1.84 1.00
150_S 155_Q 1.824 1.00
43_L 96_L 1.817 1.00
32_M 88_S 1.804 1.00
43_L 92_L 1.802 1.00
355_A 359_L 1.795 1.00
270_L 296_G 1.789 1.00
78_G 98_G 1.783 1.00
214_S 340_S 1.755 1.00
191_R 194_F 1.73 1.00
272_L 365_M 1.713 1.00
59_H 108_V 1.675 1.00
57_W 61_H 1.674 1.00
272_L 362_V 1.671 1.00
82_R 94_S 1.67 1.00
259_D 262_K 1.655 1.00
174_Q 178_E 1.651 1.00
47_T 51_L 1.65 1.00
175_S 178_E 1.619 1.00
56_S 60_Q 1.611 1.00
63_S 66_R 1.608 1.00
274_G 289_W 1.604 1.00
90_L 94_S 1.565 1.00
76_A 168_L 1.562 1.00
69_A 168_L 1.555 1.00
313_V 316_A 1.546 1.00
32_M 36_V 1.535 1.00
82_R 91_L 1.527 1.00
25_Q 28_Q 1.519 1.00
173_W 176_A 1.518 1.00
228_A 232_Y 1.499 1.00
274_G 296_G 1.498 1.00
58_L 67_S 1.472 1.00
267_A 299_G 1.469 1.00
73_L 168_L 1.465 1.00
151_E 154_Y 1.462 1.00
66_R 70_I 1.457 1.00
83_E 161_A 1.439 1.00
58_L 62_V 1.423 1.00
62_V 67_S 1.422 1.00
253_A 257_H 1.416 1.00
232_Y 235_S 1.411 1.00
76_A 161_A 1.403 0.99
158_A 162_L 1.396 0.99
81_M 84_L 1.395 0.99
80_L 84_L 1.384 0.99
70_I 74_L 1.382 0.99
206_G 332_I 1.377 0.99
224_I 230_A 1.363 0.99
243_G 247_G 1.36 0.99
51_L 54_A 1.359 0.99
319_G 323_A 1.342 0.99
224_I 233_S 1.33 0.99
240_M 294_G 1.326 0.99
269_V 365_M 1.324 0.99
342_V 346_I 1.322 0.99
66_R 69_A 1.32 0.99
74_L 78_G 1.311 0.99
22_L 147_V 1.311 0.99
93_S 97_L 1.308 0.99
89_A 92_L 1.302 0.99
265_M 365_M 1.295 0.99
261_R 265_M 1.294 0.99
71_S 101_G 1.291 0.99
141_A 238_A 1.284 0.99
327_G 330_F 1.282 0.99
54_A 57_W 1.268 0.99
62_V 66_R 1.267 0.99
250_L 253_A 1.264 0.99
60_Q 64_E 1.263 0.99
269_V 273_V 1.263 0.99
114_K 121_T 1.26 0.99
320_K 323_A 1.257 0.99
324_F 327_G 1.255 0.99
113_I 128_W 1.24 0.98
47_T 99_G 1.222 0.98
279_I 355_A 1.222 0.98
155_Q 158_A 1.222 0.98
262_K 265_M 1.217 0.98
258_Q 262_K 1.213 0.98
59_H 64_E 1.211 0.98
76_A 165_V 1.2 0.98
312_S 318_A 1.193 0.98
146_L 155_Q 1.191 0.98
34_F 345_S 1.19 0.98
67_S 70_I 1.189 0.98
174_Q 179_V 1.188 0.98
77_V 81_M 1.186 0.98
83_E 154_Y 1.183 0.98
272_L 276_C 1.183 0.98
276_C 358_A 1.178 0.98
272_L 358_A 1.174 0.98
343_L 347_S 1.174 0.98
123_L 256_R 1.164 0.97
145_W 149_H 1.162 0.97
247_G 250_L 1.158 0.97
27_R 37_A 1.157 0.97
262_K 266_L 1.154 0.97
267_A 296_G 1.149 0.97
25_Q 29_A 1.144 0.97
254_M 258_Q 1.128 0.97
60_Q 319_G 1.126 0.97
199_W 203_V 1.126 0.97
44_P 48_M 1.124 0.97
312_S 321_L 1.122 0.97
42_A 334_G 1.115 0.96
141_A 145_W 1.115 0.96
44_P 102_I 1.115 0.96
326_Q 329_G 1.108 0.96
46_V 334_G 1.099 0.96
35_S 345_S 1.095 0.96
63_S 67_S 1.094 0.96
213_A 333_A 1.092 0.96
196_P 200_T 1.092 0.96
317_I 320_K 1.091 0.96
162_L 166_V 1.09 0.96
252_P 256_R 1.086 0.96
123_L 127_L 1.085 0.96
69_A 172_W 1.078 0.95
223_Y 228_A 1.076 0.95
169_F 173_W 1.075 0.95
148_Q 231_Q 1.074 0.95
90_L 93_S 1.074 0.95
39_L 338_W 1.069 0.95
198_A 202_G 1.065 0.95
81_M 90_L 1.065 0.95
231_Q 235_S 1.063 0.95
136_G 241_T 1.061 0.95
285_L 288_L 1.056 0.95
352_M 356_F 1.054 0.95
222_F 226_I 1.052 0.95
322_V 326_Q 1.05 0.94
274_G 293_C 1.05 0.94
341_G 345_S 1.048 0.94
39_L 43_L 1.044 0.94
151_E 155_Q 1.042 0.94
144_P 234_G 1.038 0.94
196_P 199_W 1.035 0.94
276_C 280_W 1.029 0.94
122_P 252_P 1.027 0.94
84_L 158_A 1.025 0.93
251_M 299_G 1.02 0.93
246_A 249_L 1.017 0.93
29_A 154_Y 1.013 0.93
69_A 73_L 1.011 0.93
165_V 169_F 1.009 0.93
123_L 253_A 1.006 0.93
246_A 250_L 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.99221000.145Contact Map0.46
3wdoA10.9871000.163Contact Map0.62
2gfpA20.94791000.165Contact Map0.203
3o7qA10.9741000.173Contact Map0.615
4j05A20.9871000.179Contact Map0.613
2cfqA10.9871000.19Contact Map0.493
4ldsA20.98961000.226Contact Map0.622
4gc0A10.98961000.227Contact Map0.696
2xutA30.99221000.231Contact Map0.575
4apsA20.98961000.246Contact Map0.542

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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