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ARGD - Acetylornithine/succinyldiaminopimelate aminotransferase
UniProt: P18335 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10066
Length: 406 (391)
Sequences: 9680
Seq/Len: 24.76

ARGD
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
68_K 72_E 4.574 1.00
364_A 398_H 4.217 1.00
213_R 217_D 4.209 1.00
35_R 43_E 3.805 1.00
317_R 390_D 3.629 1.00
176_L 211_G 3.504 1.00
306_E 309_E 3.299 1.00
92_K 300_D 3.264 1.00
30_K 37_W 3.187 1.00
237_D 243_H 2.987 1.00
65_N 69_T 2.978 1.00
317_R 386_D 2.898 1.00
385_E 388_D 2.846 1.00
62_A 304_T 2.781 1.00
310_G 314_K 2.704 1.00
328_Q 397_A 2.7 1.00
62_A 297_A 2.571 1.00
297_A 300_D 2.495 1.00
313_A 386_D 2.482 1.00
211_G 214_E 2.372 1.00
214_E 218_Q 2.366 1.00
321_H 393_M 2.334 1.00
29_V 39_Q 2.303 1.00
47_F 392_G 2.294 1.00
92_K 303_N 2.273 1.00
62_A 301_I 2.249 1.00
360_A 363_E 2.241 1.00
60_H 301_I 2.225 1.00
172_P 178_A 2.212 1.00
364_A 402_K 2.196 1.00
316_Q 320_D 2.193 1.00
191_V 224_V 2.145 1.00
35_R 388_D 2.113 1.00
180_K 218_Q 2.106 1.00
366_V 395_R 2.03 1.00
37_W 43_E 1.953 1.00
360_A 402_K 1.947 1.00
84_E 88_R 1.907 1.00
319_V 323_Q 1.891 1.00
329_Y 397_A 1.882 1.00
179_V 212_L 1.874 1.00
133_K 186_H 1.87 1.00
92_K 296_G 1.87 1.00
29_V 73_T 1.864 1.00
360_A 364_A 1.863 1.00
89_L 295_A 1.861 1.00
67_L 294_V 1.859 1.00
64_V 68_K 1.853 1.00
391_E 395_R 1.847 1.00
91_R 95_E 1.841 1.00
101_R 270_A 1.825 1.00
321_H 390_D 1.821 1.00
192_V 212_L 1.817 1.00
105_M 264_S 1.806 1.00
38_D 42_K 1.768 1.00
137_F 208_F 1.764 1.00
321_H 324_K 1.759 1.00
321_H 394_Q 1.744 1.00
270_A 274_S 1.726 1.00
301_I 305_P 1.723 1.00
32_Q 61_P 1.72 1.00
190_V 216_C 1.716 1.00
42_K 365_G 1.695 1.00
67_L 71_G 1.68 1.00
90_G 104_F 1.648 1.00
43_E 391_E 1.592 1.00
237_D 312_Q 1.59 1.00
133_K 169_I 1.587 1.00
35_R 391_E 1.579 1.00
207_E 210_Q 1.574 1.00
310_G 313_A 1.564 1.00
112_N 252_T 1.564 1.00
319_V 337_G 1.562 1.00
253_S 265_A 1.558 1.00
92_K 95_E 1.555 1.00
314_K 389_I 1.531 1.00
177_H 180_K 1.501 1.00
309_E 313_A 1.494 1.00
258_G 263_I 1.48 1.00
253_S 267_L 1.467 1.00
100_E 270_A 1.458 1.00
65_N 68_K 1.454 1.00
314_K 317_R 1.452 1.00
180_K 184_D 1.451 1.00
183_M 221_A 1.448 1.00
88_R 296_G 1.447 1.00
69_T 73_T 1.447 1.00
28_P 36_I 1.444 1.00
225_F 241_Y 1.442 1.00
119_A 224_V 1.428 1.00
329_Y 401_A 1.425 1.00
360_A 399_A 1.425 1.00
115_A 252_T 1.422 1.00
213_R 223_L 1.416 1.00
171_V 182_V 1.414 1.00
38_D 44_Y 1.407 0.99
61_P 65_N 1.406 0.99
174_N 205_T 1.403 0.99
257_L 263_I 1.4 0.99
213_R 216_C 1.4 0.99
30_K 73_T 1.379 0.99
237_D 242_M 1.375 0.99
151_V 168_I 1.37 0.99
66_A 297_A 1.368 0.99
297_A 301_I 1.366 0.99
34_S 388_D 1.363 0.99
192_V 209_L 1.36 0.99
114_T 266_M 1.357 0.99
333_S 347_K 1.357 0.99
122_Y 272_I 1.356 0.99
361_G 368_V 1.349 0.99
177_H 181_A 1.345 0.99
314_K 386_D 1.343 0.99
60_H 305_P 1.343 0.99
59_C 64_V 1.34 0.99
102_V 267_L 1.34 0.99
250_I 268_T 1.339 0.99
94_I 102_V 1.335 0.99
88_R 300_D 1.33 0.99
263_I 292_C 1.33 0.99
116_F 134_I 1.328 0.99
138_H 172_P 1.325 0.99
67_L 290_L 1.324 0.99
384_V 389_I 1.318 0.99
34_S 383_V 1.314 0.99
364_A 399_A 1.31 0.99
319_V 342_I 1.31 0.99
32_Q 59_C 1.307 0.99
325_I 393_M 1.306 0.99
96_A 303_N 1.297 0.99
136_A 170_H 1.295 0.99
210_Q 214_E 1.292 0.99
190_V 212_L 1.292 0.99
135_I 187_T 1.291 0.99
386_D 390_D 1.288 0.99
32_Q 43_E 1.286 0.99
207_E 244_Y 1.286 0.99
225_F 246_V 1.28 0.99
296_G 300_D 1.268 0.99
317_R 321_H 1.258 0.99
112_N 191_V 1.256 0.99
241_Y 251_L 1.253 0.99
97_T 267_L 1.243 0.98
35_R 45_V 1.242 0.98
172_P 175_D 1.241 0.98
180_K 211_G 1.231 0.98
244_Y 338_M 1.221 0.98
323_Q 326_D 1.214 0.98
263_I 295_A 1.213 0.98
68_K 71_G 1.209 0.98
131_K 220_Q 1.209 0.98
397_A 401_A 1.209 0.98
56_L 301_I 1.207 0.98
238_L 242_M 1.201 0.98
222_L 272_I 1.194 0.98
212_L 223_L 1.194 0.98
320_D 324_K 1.187 0.98
101_R 274_S 1.186 0.98
95_E 303_N 1.186 0.98
247_T 269_T 1.18 0.98
151_V 191_V 1.177 0.98
394_Q 398_H 1.175 0.98
69_T 72_E 1.175 0.98
321_H 397_A 1.174 0.98
257_L 265_A 1.162 0.97
300_D 304_T 1.148 0.97
388_D 391_E 1.147 0.97
364_A 395_R 1.143 0.97
64_V 72_E 1.137 0.97
64_V 71_G 1.137 0.97
29_V 41_G 1.127 0.97
214_E 217_D 1.122 0.97
390_D 394_Q 1.104 0.96
302_I 308_L 1.101 0.96
134_I 189_A 1.094 0.96
243_H 338_M 1.093 0.96
302_I 307_V 1.093 0.96
233_G 308_L 1.086 0.96
308_L 311_I 1.084 0.96
361_G 366_V 1.084 0.96
250_I 266_M 1.079 0.95
361_G 399_A 1.079 0.95
236_G 242_M 1.075 0.95
63_L 294_V 1.073 0.95
105_M 266_M 1.07 0.95
104_F 292_C 1.07 0.95
210_Q 245_G 1.067 0.95
89_L 296_G 1.049 0.94
183_M 187_T 1.049 0.94
195_I 338_M 1.047 0.94
361_G 395_R 1.04 0.94
150_S 165_P 1.039 0.94
259_G 298_A 1.036 0.94
391_E 394_Q 1.035 0.94
109_T 148_T 1.03 0.94
325_I 397_A 1.027 0.94
180_K 219_H 1.023 0.93
215_L 219_H 1.021 0.93
366_V 392_G 1.019 0.93
387_A 390_D 1.019 0.93
309_E 312_Q 1.016 0.93
239_F 253_S 1.014 0.93
34_S 45_V 1.012 0.93
312_Q 316_Q 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a0gA40.99751000.324Contact Map0.572
3tfuA20.99011000.366Contact Map0.716
2epjA10.97291000.388Contact Map0.706
4e3qA40.99011000.39Contact Map0.785
3nx3A20.9681000.394Contact Map0.769
4ffcA40.98521000.396Contact Map0.653
1z7dA60.99751000.396Contact Map0.85
4atqA120.98031000.398Contact Map0.715
3hmuA20.99261000.399Contact Map0.81
3oksA40.97781000.399Contact Map0.733

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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