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GGT - Gamma-glutamyltranspeptidase
UniProt: P18956 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10374
Length: 580 (539)
Sequences: 2345
Seq/Len: 4.35

GGT
Paralog alert: 0.32 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
178_R 232_E 7.688 1.00
240_D 244_K 4.464 1.00
309_N 364_A 4.007 1.00
305_N 360_A 3.689 1.00
68_E 168_K 3.644 1.00
175_K 179_D 3.616 1.00
50_M 566_G 3.58 1.00
249_E 264_K 3.448 1.00
282_Y 500_D 3.113 1.00
53_S 59_T 3.1 1.00
53_S 79_V 2.994 1.00
113_F 153_G 2.776 1.00
62_G 79_V 2.646 1.00
241_E 247_I 2.572 1.00
252_A 264_K 2.516 1.00
497_N 503_L 2.488 1.00
188_A 218_K 2.44 1.00
283_R 500_D 2.433 1.00
82_A 176_L 2.417 1.00
99_M 157_A 2.371 1.00
403_A 478_V 2.349 1.00
156_L 272_A 2.302 1.00
308_E 357_K 2.298 1.00
104_K 402_N 2.278 1.00
244_K 268_A 2.274 1.00
79_V 394_Y 2.246 1.00
111_I 274_E 2.241 1.00
327_A 523_L 2.229 1.00
81_Y 170_V 2.213 1.00
174_F 235_A 2.209 1.00
303_I 492_L 2.204 1.00
305_N 357_K 2.199 1.00
469_V 495_V 2.179 1.00
46_A 579_G 2.149 1.00
505_V 555_S 2.146 1.00
226_N 422_E 2.136 1.00
214_E 220_D 2.127 1.00
321_D 540_K 2.117 1.00
171_Q 175_K 2.079 1.00
504_N 507_E 2.061 1.00
232_E 236_E 2.059 1.00
155_S 159_D 2.058 1.00
60_Q 64_D 2.043 1.00
495_V 499_I 2.004 1.00
51_V 62_G 2.003 1.00
155_S 239_P 1.997 1.00
536_L 540_K 1.962 1.00
288_Y 470_V 1.958 1.00
281_D 286_Q 1.955 1.00
309_N 361_K 1.952 1.00
324_Q 542_Q 1.942 1.00
73_V 157_A 1.93 1.00
178_R 229_K 1.926 1.00
107_N 276_T 1.909 1.00
255_M 260_G 1.905 1.00
110_A 290_M 1.896 1.00
265_E 269_A 1.883 1.00
170_V 174_F 1.848 1.00
279_S 286_Q 1.838 1.00
397_V 564_L 1.811 1.00
77_V 158_L 1.803 1.00
151_V 234_I 1.8 1.00
158_L 166_L 1.793 1.00
395_S 478_V 1.791 1.00
397_V 403_A 1.778 1.00
109_T 161_Y 1.773 1.00
535_K 538_E 1.773 1.00
185_D 218_K 1.758 0.99
233_M 241_E 1.752 0.99
160_K 274_E 1.738 0.99
320_A 536_L 1.712 0.99
51_V 79_V 1.689 0.99
120_K 263_T 1.685 0.99
273_V 345_D 1.672 0.99
264_K 268_A 1.665 0.99
152_A 239_P 1.652 0.99
506_A 510_N 1.637 0.99
48_Q 399_K 1.622 0.99
233_M 237_N 1.619 0.99
59_T 578_A 1.617 0.99
306_I 329_A 1.61 0.99
102_R 108_T 1.609 0.99
233_M 246_T 1.601 0.99
496_V 500_D 1.597 0.99
300_I 465_S 1.592 0.99
237_N 241_E 1.589 0.99
65_I 68_E 1.58 0.99
506_A 567_A 1.57 0.99
119_A 269_A 1.566 0.99
255_M 262_I 1.556 0.98
252_A 256_Q 1.554 0.98
279_S 288_Y 1.553 0.98
280_G 305_N 1.552 0.98
141_S 418_I 1.552 0.98
116_M 270_Y 1.522 0.98
65_I 164_M 1.517 0.98
280_G 301_V 1.516 0.98
509_T 555_S 1.516 0.98
510_N 570_P 1.508 0.98
311_D 314_K 1.505 0.98
145_S 427_L 1.501 0.98
142_H 255_M 1.496 0.98
97_G 153_G 1.496 0.98
156_L 159_D 1.494 0.98
252_A 263_T 1.493 0.98
65_I 169_V 1.488 0.98
362_S 365_D 1.483 0.98
79_V 396_V 1.481 0.98
152_A 272_A 1.478 0.98
325_I 369_I 1.476 0.98
217_K 220_D 1.475 0.98
552_S 572_S 1.474 0.98
156_L 274_E 1.47 0.98
249_E 253_Q 1.469 0.98
64_D 67_K 1.465 0.98
158_L 169_V 1.461 0.97
155_S 166_L 1.461 0.97
86_T 181_F 1.452 0.97
53_S 62_G 1.45 0.97
64_D 68_E 1.444 0.97
167_N 236_E 1.44 0.97
64_D 175_K 1.432 0.97
120_K 261_L 1.429 0.97
310_F 364_A 1.424 0.97
110_A 291_P 1.416 0.97
409_T 430_Q 1.407 0.97
535_K 539_A 1.401 0.97
73_V 404_V 1.401 0.97
52_A 554_Q 1.396 0.96
324_Q 328_E 1.394 0.96
361_K 364_A 1.391 0.96
97_G 113_F 1.39 0.96
298_I 341_L 1.381 0.96
477_L 498_S 1.373 0.96
158_L 163_T 1.373 0.96
322_A 501_Y 1.372 0.96
147_T 262_I 1.352 0.96
195_G 199_L 1.34 0.95
166_L 170_V 1.337 0.95
269_A 457_N 1.33 0.95
328_E 331_K 1.324 0.95
403_A 475_T 1.316 0.95
233_M 247_I 1.316 0.95
216_L 220_D 1.307 0.94
332_Y 366_Q 1.306 0.94
250_Q 423_S 1.301 0.94
98_F 293_P 1.297 0.94
102_R 106_G 1.292 0.94
534_L 544_V 1.291 0.94
117_A 457_N 1.29 0.94
112_D 275_R 1.285 0.94
100_L 110_A 1.284 0.94
328_E 542_Q 1.282 0.94
76_A 404_V 1.278 0.93
300_I 492_L 1.277 0.93
498_S 505_V 1.273 0.93
315_Y 325_I 1.27 0.93
63_V 67_K 1.267 0.93
73_V 101_I 1.263 0.93
230_S 425_I 1.254 0.93
152_A 240_D 1.245 0.92
182_I 221_T 1.24 0.92
470_V 475_T 1.237 0.92
368_D 371_K 1.229 0.92
109_T 274_E 1.227 0.91
336_D 359_Y 1.227 0.91
534_L 538_E 1.224 0.91
497_N 501_Y 1.224 0.91
77_V 169_V 1.215 0.91
111_I 157_A 1.214 0.91
494_M 553_T 1.21 0.91
493_Q 513_R 1.206 0.91
163_T 400_D 1.206 0.91
80_G 408_Y 1.197 0.90
79_V 82_A 1.191 0.90
142_H 258_N 1.19 0.90
174_F 232_E 1.189 0.90
165_P 168_K 1.188 0.90
85_V 177_A 1.182 0.89
171_Q 174_F 1.181 0.89
55_D 86_T 1.175 0.89
113_F 406_V 1.175 0.89
65_I 78_A 1.174 0.89
81_Y 151_V 1.17 0.89
71_N 163_T 1.165 0.88
265_E 268_A 1.164 0.88
119_A 457_N 1.164 0.88
111_I 161_Y 1.163 0.88
323_M 327_A 1.16 0.88
505_V 567_A 1.159 0.88
250_Q 422_E 1.158 0.88
281_D 308_E 1.157 0.88
145_S 418_I 1.157 0.88
99_M 153_G 1.156 0.88
531_P 535_K 1.155 0.88
346_F 458_K 1.153 0.88
158_L 165_P 1.15 0.88
246_T 249_E 1.15 0.88
361_K 365_D 1.15 0.88
158_L 164_M 1.15 0.88
117_A 121_A 1.15 0.88
229_K 232_E 1.144 0.87
322_A 326_M 1.142 0.87
481_S 490_T 1.14 0.87
477_L 557_M 1.14 0.87
302_Q 336_D 1.139 0.87
289_S 491_V 1.135 0.87
251_I 427_L 1.134 0.87
533_T 536_L 1.132 0.86
224_Q 425_I 1.129 0.86
49_G 66_L 1.126 0.86
116_M 457_N 1.125 0.86
253_Q 257_K 1.121 0.86
306_I 364_A 1.121 0.86
475_T 478_V 1.119 0.86
101_I 157_A 1.115 0.85
536_L 539_A 1.115 0.85
244_K 248_A 1.115 0.85
247_I 250_Q 1.111 0.85
505_V 509_T 1.109 0.85
111_I 272_A 1.107 0.85
285_Y 499_I 1.106 0.85
61_V 82_A 1.099 0.84
478_V 556_I 1.099 0.84
359_Y 363_I 1.092 0.84
58_A 83_L 1.089 0.83
363_I 366_Q 1.083 0.83
486_R 490_T 1.078 0.83
412_T 443_V 1.075 0.82
156_L 160_K 1.072 0.82
102_R 105_N 1.069 0.82
394_Y 406_V 1.066 0.82
84_A 231_L 1.063 0.81
50_M 579_G 1.058 0.81
54_V 87_H 1.058 0.81
479_T 494_M 1.057 0.81
303_I 333_A 1.057 0.81
178_R 225_A 1.054 0.81
77_V 154_F 1.054 0.81
303_I 330_E 1.051 0.80
65_I 168_K 1.05 0.80
52_A 568_S 1.05 0.80
68_E 164_M 1.049 0.80
321_D 369_I 1.047 0.80
91_G 408_Y 1.044 0.80
559_G 565_Y 1.042 0.79
202_H 205_S 1.036 0.79
115_E 430_Q 1.032 0.79
285_Y 471_K 1.032 0.79
285_Y 476_W 1.031 0.78
151_V 239_P 1.031 0.78
280_G 360_A 1.027 0.78
280_G 357_K 1.025 0.78
357_K 360_A 1.024 0.78
60_Q 67_K 1.024 0.78
420_A 425_I 1.018 0.77
304_L 495_V 1.016 0.77
229_K 236_E 1.016 0.77
205_S 210_W 1.014 0.77
250_Q 253_Q 1.014 0.77
61_V 173_A 1.01 0.76
303_I 329_A 1.006 0.76
201_N 204_N 1.006 0.76
395_S 403_A 1.005 0.76
73_V 402_N 1.004 0.76
208_I 224_Q 1.002 0.76
503_L 511_A 1 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2e0wA20.95691000.04Contact Map0.818
2nlzA40.90691000.099Contact Map0.791
2i3oA40.87411000.12Contact Map0.737
2v36A20.63791000.4Contact Map0.747
2dg5A20.62931000.409Contact Map0.783
2qmcA20.64311000.415Contact Map0.811
4gdxA10.62931000.436Contact Map0.844
3g9kL20.54661000.471Contact Map0.695
2dg5B20.32761000.647Contact Map0.881
4gdxB10.33281000.653Contact Map0.903

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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