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BISC - Biotin sulfoxide reductase
UniProt: P20099 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10124
Length: 777 (740)
Sequences: 4628
Seq/Len: 6.25

BISC
Paralog alert: 0.80 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: BISC DMSA FDHF FDNG FDOG NAPA TORA TORZ YDEP YNFE YNFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_F 84_R 6.537 1.00
680_I 699_A 6.345 1.00
92_D 517_R 5.923 1.00
687_R 759_E 5.087 1.00
252_G 296_A 4.381 1.00
684_D 760_K 4.347 1.00
260_N 312_A 4.342 1.00
674_D 708_G 4.255 1.00
505_R 513_E 4.251 1.00
636_L 678_R 3.983 1.00
91_L 517_R 3.947 1.00
93_L 467_I 3.712 1.00
256_T 260_N 3.707 1.00
294_E 304_A 3.655 1.00
670_I 699_A 3.585 1.00
509_D 513_E 3.472 1.00
453_I 465_A 3.308 1.00
85_V 467_I 3.305 1.00
185_W 250_M 3.241 1.00
94_I 467_I 3.229 1.00
687_R 694_Q 3.209 1.00
686_V 699_A 3.191 1.00
673_D 707_P 3.18 1.00
97_Q 100_R 3.125 1.00
254_A 346_M 3.096 1.00
297_A 304_A 3.086 1.00
265_E 269_A 3.062 1.00
249_L 300_C 3.049 1.00
496_Q 499_P 3.047 1.00
254_A 278_F 3.046 1.00
255_H 259_E 3.027 1.00
670_I 758_L 3.018 1.00
690_N 756_A 2.98 1.00
62_V 467_I 2.969 1.00
273_T 597_S 2.948 1.00
86_S 89_E 2.78 1.00
101_I 109_S 2.777 1.00
62_V 85_V 2.724 1.00
84_R 503_E 2.724 1.00
100_R 104_A 2.695 1.00
94_I 452_V 2.685 1.00
689_W 757_W 2.682 1.00
91_L 513_E 2.679 1.00
220_C 232_F 2.663 1.00
304_A 308_R 2.662 1.00
680_I 686_V 2.653 1.00
59_F 503_E 2.646 1.00
217_K 313_I 2.642 1.00
597_S 601_E 2.635 1.00
62_V 93_L 2.621 1.00
513_E 517_R 2.601 1.00
675_A 701_I 2.595 1.00
677_E 707_P 2.592 1.00
689_W 759_E 2.533 1.00
180_D 318_T 2.524 1.00
678_R 757_W 2.495 1.00
98_H 423_F 2.481 1.00
303_G 306_K 2.478 1.00
64_K 83_V 2.425 1.00
292_T 295_W 2.423 1.00
255_H 293_A 2.347 1.00
306_K 309_E 2.335 1.00
85_V 93_L 2.325 1.00
256_T 293_A 2.324 1.00
263_H 268_L 2.312 1.00
437_D 739_D 2.3 1.00
179_S 182_V 2.292 1.00
245_T 299_I 2.279 1.00
239_V 310_L 2.272 1.00
668_V 710_I 2.267 1.00
682_D 701_I 2.266 1.00
296_A 307_I 2.259 1.00
181_V 313_I 2.235 1.00
352_T 355_G 2.232 1.00
62_V 83_V 2.225 1.00
425_W 454_S 2.212 1.00
668_V 686_V 2.211 1.00
256_T 312_A 2.186 1.00
266_A 270_R 2.182 1.00
309_E 313_I 2.176 1.00
689_W 694_Q 2.16 1.00
261_G 265_E 2.158 1.00
239_V 302_V 2.157 1.00
501_R 504_A 2.13 1.00
181_V 219_I 2.121 1.00
422_R 449_E 2.115 1.00
178_H 353_P 2.112 1.00
260_N 308_R 2.109 1.00
249_L 307_I 2.102 1.00
268_L 275_Y 2.086 1.00
237_E 309_E 2.042 1.00
61_M 468_V 2.032 1.00
294_E 308_R 2.03 1.00
93_L 97_Q 2.02 1.00
221_I 249_L 2.005 1.00
256_T 262_W 1.997 1.00
262_W 315_H 1.996 1.00
668_V 688_L 1.991 1.00
297_A 303_G 1.99 1.00
710_I 756_A 1.977 1.00
89_E 93_L 1.957 1.00
253_I 314_F 1.951 1.00
258_V 282_L 1.947 1.00
211_L 216_K 1.947 1.00
450_L 467_I 1.941 1.00
697_A 712_I 1.935 1.00
458_W 462_A 1.934 1.00
76_I 79_Q 1.917 1.00
531_S 534_Q 1.915 1.00
241_P 302_V 1.9 1.00
58_R 502_Y 1.887 1.00
636_L 710_I 1.877 1.00
314_F 347_L 1.851 1.00
478_N 496_Q 1.85 1.00
670_I 710_I 1.848 1.00
681_Q 684_D 1.83 1.00
448_P 451_V 1.806 1.00
258_V 279_A 1.8 1.00
258_V 275_Y 1.797 1.00
272_T 602_I 1.793 1.00
277_V 280_S 1.785 1.00
262_W 312_A 1.782 1.00
89_E 467_I 1.777 1.00
181_V 310_L 1.773 1.00
223_P 238_W 1.773 1.00
685_T 696_L 1.769 1.00
259_E 308_R 1.767 1.00
248_A 299_I 1.76 1.00
668_V 712_I 1.752 1.00
183_V 221_I 1.751 1.00
101_I 423_F 1.751 1.00
256_T 308_R 1.738 1.00
453_I 462_A 1.734 1.00
257_L 263_H 1.715 1.00
673_D 676_Q 1.714 1.00
682_D 700_V 1.701 1.00
678_R 758_L 1.695 1.00
21_V 28_V 1.694 1.00
685_T 698_G 1.689 1.00
60_P 87_W 1.682 1.00
641_A 711_C 1.679 1.00
28_V 51_V 1.674 1.00
297_A 307_I 1.669 1.00
249_L 310_L 1.662 1.00
183_V 310_L 1.658 1.00
626_E 692_R 1.626 1.00
239_V 306_K 1.62 1.00
687_R 696_L 1.618 1.00
263_H 275_Y 1.613 1.00
314_F 319_T 1.605 1.00
670_I 680_I 1.603 1.00
106_G 109_S 1.599 1.00
669_T 702_S 1.587 0.99
636_L 757_W 1.584 0.99
94_I 469_L 1.576 0.99
212_R 233_G 1.573 0.99
133_Y 518_W 1.569 0.99
245_T 300_C 1.548 0.99
98_H 452_V 1.546 0.99
636_L 674_D 1.537 0.99
454_S 510_V 1.532 0.99
253_I 257_L 1.531 0.99
85_V 89_E 1.531 0.99
325_W 329_R 1.529 0.99
237_E 306_K 1.521 0.99
291_K 296_A 1.52 0.99
472_T 506_N 1.513 0.99
105_Y 422_R 1.509 0.99
631_A 691_A 1.49 0.99
426_W 451_V 1.488 0.99
346_M 602_I 1.485 0.99
442_I 446_Q 1.477 0.99
92_D 96_Q 1.458 0.99
513_E 516_E 1.449 0.99
295_W 298_E 1.444 0.99
61_M 84_R 1.443 0.99
183_V 253_I 1.437 0.99
443_R 446_Q 1.434 0.99
58_R 84_R 1.434 0.99
266_A 269_A 1.434 0.99
93_L 450_L 1.42 0.99
101_I 449_E 1.418 0.99
505_R 509_D 1.415 0.99
99_K 103_E 1.401 0.98
96_Q 100_R 1.399 0.98
702_S 705_I 1.386 0.98
22_E 32_R 1.386 0.98
291_K 295_W 1.383 0.98
221_I 310_L 1.381 0.98
101_I 450_L 1.381 0.98
695_I 712_I 1.379 0.98
220_C 229_V 1.379 0.98
250_M 340_I 1.379 0.98
688_L 712_I 1.375 0.98
182_V 211_L 1.368 0.98
182_V 208_F 1.364 0.98
671_H 707_P 1.361 0.98
57_V 468_V 1.361 0.98
349_Q 355_G 1.357 0.98
258_V 263_H 1.356 0.98
185_W 221_I 1.356 0.98
219_I 310_L 1.355 0.98
297_A 305_A 1.343 0.98
273_T 601_E 1.34 0.98
256_T 307_I 1.329 0.98
257_L 315_H 1.327 0.97
633_P 691_A 1.316 0.97
278_F 346_M 1.314 0.97
252_G 307_I 1.309 0.97
182_V 216_K 1.292 0.97
64_K 81_E 1.289 0.97
417_H 440_R 1.287 0.97
291_K 299_I 1.281 0.97
225_R 230_D 1.279 0.97
469_L 510_V 1.279 0.97
256_T 259_E 1.27 0.97
91_L 509_D 1.269 0.96
21_V 31_S 1.264 0.96
91_L 505_R 1.261 0.96
275_Y 346_M 1.257 0.96
472_T 504_A 1.255 0.96
541_N 544_R 1.255 0.96
275_Y 279_A 1.254 0.96
91_L 514_L 1.251 0.96
665_R 698_G 1.251 0.96
109_S 422_R 1.241 0.96
670_I 675_A 1.238 0.96
672_P 703_E 1.236 0.96
88_D 517_R 1.235 0.96
259_E 293_A 1.231 0.96
253_I 310_L 1.231 0.96
94_I 450_L 1.225 0.95
83_V 89_E 1.224 0.95
20_L 35_L 1.221 0.95
556_P 559_E 1.216 0.95
98_H 518_W 1.215 0.95
454_S 471_A 1.212 0.95
458_W 468_V 1.207 0.95
265_E 279_A 1.199 0.95
31_S 48_R 1.195 0.95
425_W 514_L 1.192 0.95
669_T 700_V 1.19 0.94
516_E 523_Y 1.187 0.94
509_D 516_E 1.184 0.94
636_L 758_L 1.176 0.94
133_Y 515_S 1.173 0.94
301_G 706_K 1.173 0.94
255_H 292_T 1.171 0.94
293_A 308_R 1.169 0.94
595_T 601_E 1.165 0.94
184_L 218_L 1.163 0.94
345_A 600_I 1.16 0.93
297_A 300_C 1.158 0.93
456_C 473_T 1.155 0.93
268_L 346_M 1.154 0.93
668_V 697_A 1.147 0.93
255_H 282_L 1.146 0.93
87_W 510_V 1.146 0.93
241_P 245_T 1.143 0.93
680_I 701_I 1.13 0.92
296_A 300_C 1.128 0.92
87_W 469_L 1.125 0.92
148_S 155_I 1.125 0.92
668_V 758_L 1.121 0.92
505_R 510_V 1.119 0.92
256_T 311_A 1.117 0.92
432_F 442_I 1.112 0.91
26_E 29_F 1.112 0.91
252_G 256_T 1.11 0.91
98_H 137_A 1.109 0.91
51_V 498_V 1.108 0.91
268_L 602_I 1.107 0.91
99_K 102_R 1.107 0.91
314_F 321_L 1.103 0.91
692_R 737_T 1.097 0.91
712_I 733_V 1.097 0.91
253_I 343_L 1.094 0.90
98_H 425_W 1.093 0.90
212_R 231_F 1.093 0.90
250_M 339_M 1.091 0.90
417_H 443_R 1.09 0.90
27_T 52_H 1.089 0.90
642_H 646_R 1.086 0.90
257_L 314_F 1.085 0.90
82_F 468_V 1.084 0.90
305_A 308_R 1.083 0.90
670_I 701_I 1.081 0.90
559_E 564_N 1.081 0.90
184_L 187_A 1.076 0.89
498_V 501_R 1.068 0.89
253_I 311_A 1.064 0.89
506_N 509_D 1.06 0.89
256_T 304_A 1.059 0.88
247_V 336_K 1.058 0.88
636_L 671_H 1.056 0.88
21_V 475_F 1.055 0.88
223_P 240_A 1.055 0.88
423_F 450_L 1.054 0.88
242_H 706_K 1.054 0.88
626_E 691_A 1.05 0.88
423_F 452_V 1.049 0.88
52_H 501_R 1.048 0.88
210_A 213_D 1.044 0.88
212_R 218_L 1.044 0.88
23_T 29_F 1.041 0.87
263_H 346_M 1.041 0.87
251_L 291_K 1.041 0.87
23_T 26_E 1.039 0.87
473_T 501_R 1.037 0.87
412_N 421_I 1.035 0.87
297_A 302_V 1.03 0.87
596_A 601_E 1.028 0.86
237_E 310_L 1.028 0.86
478_N 495_K 1.027 0.86
180_D 214_S 1.024 0.86
112_A 134_M 1.023 0.86
490_H 568_E 1.021 0.86
257_L 347_L 1.015 0.85
274_G 277_V 1.015 0.85
495_K 561_W 1.013 0.85
593_L 600_I 1.013 0.85
427_A 511_F 1.011 0.85
423_F 467_I 1.009 0.85
280_S 289_I 1.008 0.85
407_G 415_N 1.005 0.85
342_T 602_I 1.005 0.85
95_H 517_R 1.004 0.85
62_V 89_E 1.004 0.85
572_N 576_E 1.003 0.85
97_Q 101_I 1 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1eu1A10.98581000.163Contact Map0.777
1tmoA10.98581000.188Contact Map0.708
1ti6A60.9551000.257Contact Map0.829
1kqfA10.89581000.266Contact Map0.745
1h0hA20.8971000.271Contact Map0.723
2e7zA10.86621000.272Contact Map0.776
3ml1A10.8791000.273Contact Map0.763
2vpzA20.88931000.275Contact Map0.759
2ivfA10.89191000.277Contact Map0.775
2iv2X10.871000.282Contact Map0.795

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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