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ACPH - Acyl carrier protein phosphodiesterase
UniProt: P21515 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11095
Length: 193 (191)
Sequences: 321
Seq/Len: 1.68

ACPH
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_H 170_Y 3.362 1.00
8_H 181_Y 2.632 1.00
64_W 176_R 2.247 0.99
61_A 81_W 2.171 0.99
44_M 48_I 2.109 0.99
84_F 170_Y 2.079 0.99
10_A 16_S 2.069 0.99
131_Q 134_V 1.951 0.98
7_L 21_L 1.856 0.97
88_H 174_E 1.848 0.97
28_G 46_R 1.8 0.96
106_R 131_Q 1.782 0.96
96_F 104_Y 1.77 0.96
57_E 183_R 1.762 0.96
79_V 145_V 1.725 0.95
145_V 148_G 1.598 0.92
7_L 105_A 1.559 0.91
32_E 39_V 1.506 0.89
86_S 98_L 1.46 0.86
144_N 148_G 1.456 0.86
92_L 178_W 1.449 0.86
61_A 176_R 1.446 0.86
61_A 65_F 1.419 0.84
18_S 116_S 1.401 0.83
9_L 180_F 1.382 0.82
31_E 34_F 1.351 0.80
51_L 180_F 1.346 0.80
90_S 99_Q 1.304 0.77
120_F 125_N 1.284 0.75
69_T 161_D 1.278 0.75
60_E 191_K 1.271 0.74
86_S 102_V 1.271 0.74
58_V 81_W 1.263 0.73
7_L 16_S 1.26 0.73
16_S 20_N 1.249 0.72
5_A 53_D 1.238 0.71
83_H 125_N 1.236 0.71
44_M 50_V 1.232 0.71
36_P 39_V 1.222 0.70
41_G 174_E 1.216 0.69
2_N 6_H 1.214 0.69
26_V 120_F 1.214 0.69
54_N 59_R 1.199 0.68
148_G 151_S 1.195 0.67
52_T 180_F 1.173 0.65
102_V 134_V 1.171 0.65
1_M 6_H 1.171 0.65
75_I 155_R 1.159 0.64
104_Y 140_D 1.157 0.64
92_L 141_F 1.152 0.63
38_V 67_S 1.143 0.62
27_R 50_V 1.139 0.62
86_S 127_L 1.136 0.62
10_A 21_L 1.118 0.60
10_A 70_R 1.105 0.58
13_A 16_S 1.097 0.57
186_A 190_R 1.092 0.57
42_I 46_R 1.088 0.57
115_D 183_R 1.086 0.56
80_M 166_L 1.081 0.56
62_R 73_A 1.075 0.55
83_H 137_R 1.074 0.55
42_I 116_S 1.074 0.55
20_N 41_G 1.067 0.54
105_A 149_M 1.067 0.54
58_V 177_F 1.066 0.54
51_L 61_A 1.065 0.54
60_E 168_A 1.06 0.54
4_L 98_L 1.053 0.53
66_R 165_D 1.04 0.51
2_N 5_A 1.035 0.51
124_N 128_W 1.028 0.50
5_A 52_T 1.026 0.50
62_R 93_S 1.023 0.50
76_T 162_S 1.021 0.49
50_V 54_N 1.02 0.49
142_I 148_G 1.019 0.49
178_W 182_P 1.018 0.49
157_D 160_R 1.017 0.49
91_Q 179_Q 1.011 0.48
13_A 37_D 1.008 0.48
25_F 150_A 1.006 0.48
41_G 79_V 1.004 0.48
15_S 148_G 1.001 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ebfX10.9119610.944Contact Map0.14
2bmbA10.35238.50.964Contact Map0.044
2jqtA10.32647.10.965Contact Map0.285
1wa5C10.86536.50.966Contact Map0.138
1u8vA40.72025.80.967Contact Map0.093
3lb2A20.26424.70.968Contact Map0.584
2k7rA10.2854.70.968Contact Map0.039
1v54E20.48193.50.97Contact Map0.219
3evoA20.35753.20.971Contact Map0.366
3fkbA60.35753.10.971Contact Map0.526

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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