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ADD - Adenosine deaminase
UniProt: P22333 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10030
Length: 333 (329)
Sequences: 1650
Seq/Len: 5.02

ADD
Paralog alert: 0.20 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
193_H 217_E 4.354 1.00
77_R 125_E 3.791 1.00
234_F 238_Q 3.723 1.00
212_R 234_F 3.212 1.00
81_F 129_T 2.989 1.00
80_A 119_V 2.79 1.00
224_K 227_E 2.757 1.00
301_S 304_Q 2.644 1.00
92_L 287_I 2.579 1.00
93_H 329_K 2.549 1.00
77_R 121_D 2.487 1.00
310_I 331_A 2.456 1.00
9_T 312_G 2.39 1.00
314_E 327_R 2.379 1.00
207_I 225_A 2.341 1.00
178_S 209_Q 2.311 1.00
309_Q 312_G 2.266 1.00
20_R 86_D 2.226 1.00
233_D 237_E 2.187 1.00
264_K 268_E 2.15 1.00
59_F 279_D 2.113 1.00
225_A 235_L 2.084 1.00
319_S 322_E 2.078 1.00
113_A 158_A 1.997 1.00
318_L 322_E 1.934 1.00
264_K 304_Q 1.889 1.00
220_G 243_E 1.878 1.00
241_G 315_M 1.874 1.00
30_Q 78_R 1.853 1.00
211_I 240_I 1.795 1.00
268_E 304_Q 1.778 1.00
313_L 326_L 1.772 1.00
81_F 130_F 1.766 1.00
9_T 313_L 1.75 1.00
275_I 294_A 1.743 1.00
87_A 95_V 1.734 1.00
291_Y 309_Q 1.732 1.00
91_G 288_I 1.728 1.00
81_F 125_E 1.724 1.00
55_D 58_S 1.687 0.99
78_R 82_E 1.663 0.99
285_V 289_H 1.636 0.99
310_I 327_R 1.63 0.99
38_Q 42_T 1.625 0.99
205_E 209_Q 1.612 0.99
258_L 293_V 1.591 0.99
123_V 134_A 1.585 0.99
256_A 260_A 1.579 0.99
247_T 290_E 1.579 0.99
257_E 260_A 1.575 0.99
154_E 186_R 1.575 0.99
20_R 82_E 1.566 0.99
186_R 189_D 1.562 0.99
146_E 182_S 1.558 0.99
85_E 129_T 1.553 0.99
145_G 148_A 1.537 0.99
153_L 183_H 1.525 0.99
98_R 167_D 1.524 0.99
241_G 274_S 1.506 0.99
77_R 122_G 1.496 0.98
94_Y 133_Q 1.488 0.98
300_L 308_A 1.479 0.98
39_S 42_T 1.473 0.98
125_E 129_T 1.472 0.98
239_Q 272_R 1.47 0.98
73_L 114_G 1.445 0.98
267_L 300_L 1.437 0.98
235_L 242_I 1.428 0.98
137_I 165_A 1.424 0.98
229_R 269_H 1.409 0.98
212_R 238_Q 1.408 0.98
209_Q 213_E 1.408 0.98
26_E 78_R 1.389 0.97
22_Q 44_I 1.365 0.97
82_E 86_D 1.361 0.97
84_I 134_A 1.361 0.97
19_I 79_V 1.359 0.97
20_R 78_R 1.347 0.97
219_I 222_G 1.344 0.96
233_D 269_H 1.336 0.96
175_F 179_L 1.328 0.96
120_I 124_R 1.319 0.96
67_V 103_Y 1.316 0.96
266_F 271_I 1.3 0.95
272_R 314_E 1.278 0.95
239_Q 314_E 1.273 0.95
156_F 192_W 1.27 0.95
208_W 228_D 1.264 0.95
157_L 160_R 1.261 0.94
127_C 133_Q 1.26 0.94
279_D 283_Q 1.259 0.94
274_S 315_M 1.256 0.94
292_T 296_P 1.248 0.94
195_T 317_F 1.237 0.94
188_R 215_G 1.233 0.94
211_I 234_F 1.23 0.93
264_K 300_L 1.229 0.93
13_R 18_N 1.224 0.93
98_R 139_I 1.21 0.93
83_N 97_L 1.196 0.92
149_C 183_H 1.19 0.92
289_H 293_V 1.19 0.92
138_G 163_I 1.19 0.92
316_A 323_K 1.182 0.92
149_C 180_F 1.181 0.91
223_V 254_T 1.18 0.91
188_R 194_I 1.172 0.91
140_M 166_L 1.169 0.91
306_R 310_I 1.168 0.91
20_R 23_T 1.168 0.91
138_G 156_F 1.156 0.90
272_R 315_M 1.15 0.90
320_A 324_R 1.148 0.90
313_L 330_V 1.145 0.90
187_A 191_G 1.144 0.90
226_I 232_M 1.139 0.89
153_L 157_L 1.132 0.89
30_Q 74_D 1.128 0.89
307_Q 314_E 1.126 0.89
275_I 291_Y 1.124 0.89
223_V 255_V 1.123 0.88
98_R 165_A 1.12 0.88
324_R 328_E 1.118 0.88
263_L 294_A 1.118 0.88
150_Q 154_E 1.117 0.88
187_A 192_W 1.116 0.88
135_K 322_E 1.109 0.88
194_I 216_A 1.108 0.88
236_A 271_I 1.108 0.88
275_I 308_A 1.104 0.87
226_I 266_F 1.098 0.87
26_E 82_E 1.097 0.87
56_L 60_L 1.095 0.87
94_Y 135_K 1.094 0.87
15_L 97_L 1.093 0.87
265_T 268_E 1.089 0.86
150_Q 186_R 1.088 0.86
20_R 85_E 1.087 0.86
322_E 325_A 1.083 0.86
310_I 314_E 1.081 0.86
74_D 78_R 1.081 0.86
116_V 138_G 1.079 0.86
80_A 84_I 1.076 0.85
198_A 210_A 1.075 0.85
313_L 327_R 1.066 0.85
246_L 294_A 1.06 0.84
121_D 125_E 1.058 0.84
78_R 86_D 1.056 0.84
90_H 288_I 1.048 0.83
223_V 249_N 1.043 0.83
157_L 186_R 1.042 0.83
154_E 158_A 1.039 0.83
97_L 136_L 1.039 0.83
208_W 231_L 1.038 0.83
57_V 171_D 1.035 0.82
307_Q 311_N 1.032 0.82
295_A 302_R 1.032 0.82
181_L 185_N 1.024 0.81
291_Y 295_A 1.023 0.81
255_V 262_P 1.022 0.81
171_D 174_G 1.015 0.81
25_L 37_A 1.015 0.81
113_A 159_H 1.012 0.80
230_A 233_D 1.01 0.80
139_I 169_A 1.001 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3iarA10.9941000.276Contact Map0.75
3rysA20.9851000.276Contact Map0.713
2pgfA10.9851000.278Contact Map0.726
4gxwA20.9851000.284Contact Map0.666
3lgdA20.9971000.295Contact Map0.675
3paoA20.9671000.324Contact Map0.81
2a3lA10.9581000.374Contact Map0.564
1p1mA10.831899.60.832Contact Map0.516
4gbdA20.840899.50.834Contact Map0.47
3lnpA10.840899.50.842Contact Map0.486

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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