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LIVF - High-affinity branched-chain amino acid transport ATP-binding protein LivF
UniProt: P22731 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10536
Length: 237 (232)
Sequences: 71697
Seq/Len: 309.04

LIVF
Paralog alert: 0.94 [within 20: 0.82] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
35_T 204_A 3.361 1.00
7_S 27_H 3.153 1.00
32_E 206_R 3.145 1.00
61_R 68_D 3.077 1.00
10_K 23_E 2.962 1.00
9_D 61_R 2.954 1.00
130_R 133_Q 2.946 1.00
34_V 208_Y 2.871 1.00
19_Q 22_H 2.78 1.00
7_S 63_V 2.712 1.00
81_A 157_R 2.62 1.00
22_H 214_H 2.597 1.00
29_N 32_E 2.536 1.00
206_R 218_S 2.421 1.00
12_S 23_E 2.33 1.00
8_F 11_V 2.319 1.00
14_H 19_Q 2.308 1.00
12_S 19_Q 2.271 1.00
219_D 223_A 2.193 1.00
65_D 157_R 2.182 1.00
97_V 138_M 2.158 1.00
12_S 59_S 2.111 1.00
9_D 63_V 2.082 1.00
220_T 223_A 2.047 1.00
122_E 128_H 2.02 1.00
13_A 50_T 2.01 1.00
98_E 132_I 1.849 1.00
116_R 155_N 1.803 1.00
30_Q 157_R 1.767 1.00
155_N 188_M 1.757 1.00
32_E 205_D 1.746 1.00
208_Y 215_V 1.733 1.00
10_K 25_S 1.732 1.00
15_Y 20_A 1.719 1.00
98_E 131_R 1.717 1.00
208_Y 218_S 1.658 1.00
121_Y 131_R 1.623 1.00
133_Q 137_T 1.615 1.00
13_A 58_T 1.575 1.00
14_H 58_T 1.575 1.00
48_L 193_V 1.522 1.00
98_E 102_A 1.517 1.00
123_L 182_Q 1.506 1.00
109_E 112_Q 1.502 1.00
118_K 131_R 1.493 1.00
48_L 160_L 1.451 1.00
63_V 68_D 1.448 1.00
116_R 119_W 1.44 1.00
28_I 34_V 1.434 1.00
87_E 140_G 1.416 1.00
26_L 208_Y 1.416 1.00
21_L 50_T 1.411 1.00
184_R 205_D 1.406 0.99
9_D 27_H 1.39 0.99
50_T 57_A 1.389 0.99
182_Q 186_Q 1.354 0.99
119_W 123_L 1.349 0.99
13_A 55_P 1.348 0.99
114_Q 118_K 1.347 0.99
98_E 118_K 1.341 0.99
116_R 120_V 1.333 0.99
128_H 131_R 1.307 0.99
8_F 51_L 1.299 0.99
96_T 99_E 1.294 0.99
12_S 22_H 1.29 0.99
161_L 180_I 1.271 0.99
194_E 200_A 1.264 0.99
8_F 26_L 1.259 0.99
5_M 65_D 1.256 0.99
34_V 218_S 1.255 0.99
101_L 153_M 1.249 0.99
49_G 55_P 1.244 0.98
11_V 57_A 1.24 0.98
115_E 119_W 1.234 0.98
118_K 122_E 1.218 0.98
9_D 25_S 1.215 0.98
157_R 188_M 1.205 0.98
65_D 81_A 1.204 0.98
100_N 150_R 1.199 0.98
29_N 206_R 1.197 0.98
123_L 186_Q 1.19 0.98
98_E 117_I 1.156 0.97
117_I 121_Y 1.156 0.97
73_Q 76_K 1.152 0.97
13_A 46_T 1.143 0.97
130_R 142_E 1.133 0.97
52_C 84_I 1.124 0.97
47_L 210_L 1.124 0.97
33_I 184_R 1.122 0.97
8_F 47_L 1.114 0.96
102_A 113_F 1.112 0.96
98_E 114_Q 1.112 0.96
182_Q 185_E 1.108 0.96
97_V 146_L 1.108 0.96
179_T 182_Q 1.105 0.96
112_Q 116_R 1.083 0.96
181_E 184_R 1.079 0.95
183_L 188_M 1.076 0.95
118_K 128_H 1.069 0.95
173_I 199_Q 1.065 0.95
175_Q 178_D 1.065 0.95
30_Q 65_D 1.064 0.95
211_E 216_V 1.063 0.95
219_D 224_L 1.061 0.95
134_R 137_T 1.059 0.95
34_V 206_R 1.05 0.94
177_F 199_Q 1.05 0.94
14_H 20_A 1.047 0.94
119_W 155_N 1.031 0.94
119_W 122_E 1.031 0.94
36_L 47_L 1.03 0.94
33_I 190_I 1.03 0.94
68_D 71_D 1.026 0.94
33_I 192_L 1.013 0.93
184_R 190_I 1.008 0.93
173_I 196_N 1.005 0.93
10_K 59_S 1.005 0.93
24_V 47_L 1.003 0.93
53_G 56_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9958100-0.041Contact Map0.873
2yyzA10.9747100-0.038Contact Map0.793
1v43A10.9747100-0.038Contact Map0.824
2it1A20.9747100-0.037Contact Map0.86
1g29120.9873100-0.035Contact Map0.886
3fvqA20.9916100-0.032Contact Map0.78
3rlfA20.9747100-0.031Contact Map0.835
1z47A20.9831100-0.031Contact Map0.833
1oxxK10.9873100-0.031Contact Map0.777
1ji0A11100-0.026Contact Map0.803

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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