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PHOQ - Sensor protein PhoQ
UniProt: P23837 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10732
Length: 486 (458)
Sequences: 2609
Seq/Len: 5.70

PHOQ
Paralog alert: 0.69 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
458_G 476_F 4.563 1.00
429_F 460_I 4.076 1.00
462_A 472_M 3.972 1.00
90_D 94_Q 3.971 1.00
394_C 416_D 3.848 1.00
414_E 471_R 3.84 1.00
415_D 419_G 3.671 1.00
425_R 464_E 3.545 1.00
449_A 460_I 3.446 1.00
450_R 454_E 3.434 1.00
453_T 458_G 3.12 1.00
287_Q 312_S 3.109 1.00
382_V 452_I 3.065 1.00
382_V 474_V 2.781 1.00
383_M 411_I 2.739 1.00
344_L 383_M 2.727 1.00
347_L 387_L 2.697 1.00
427_V 430_D 2.66 1.00
415_D 469_G 2.645 1.00
428_I 462_A 2.556 1.00
420_I 428_I 2.553 1.00
453_T 474_V 2.507 1.00
462_A 470_A 2.487 1.00
374_G 456_Y 2.469 1.00
421_P 424_K 2.467 1.00
49_F 155_M 2.456 1.00
270_T 274_D 2.44 1.00
338_H 379_F 2.437 1.00
290_L 307_M 2.402 1.00
465_S 468_G 2.369 1.00
464_E 470_A 2.326 1.00
388_D 392_K 2.307 1.00
374_G 379_F 2.285 1.00
458_G 477_G 2.178 1.00
459_K 475_I 2.142 1.00
382_V 453_T 2.119 1.00
14_R 215_W 2.105 1.00
444_V 448_V 2.073 1.00
339_P 369_E 2.016 1.00
409_L 478_R 1.989 1.00
268_Y 272_L 1.974 1.00
365_D 401_S 1.973 1.00
399_E 414_E 1.953 1.00
412_V 473_E 1.949 1.00
412_V 471_R 1.946 1.00
436_D 439_R 1.927 1.00
393_Y 434_R 1.921 1.00
385_N 449_A 1.92 1.00
395_L 416_D 1.883 1.00
355_Y 391_C 1.878 1.00
452_I 456_Y 1.847 1.00
387_L 400_I 1.837 1.00
372_F 409_L 1.825 1.00
348_T 400_I 1.811 1.00
344_L 402_A 1.806 1.00
463_G 473_E 1.805 1.00
463_G 471_R 1.802 1.00
299_S 302_D 1.798 1.00
429_F 472_M 1.797 1.00
401_S 414_E 1.772 1.00
410_Y 475_I 1.756 1.00
425_R 462_A 1.74 1.00
365_D 399_E 1.704 1.00
405_T 410_Y 1.695 1.00
336_E 376_Q 1.688 1.00
340_V 409_L 1.67 1.00
453_T 460_I 1.654 1.00
460_I 472_M 1.64 1.00
337_L 371_S 1.64 1.00
403_R 412_V 1.639 1.00
386_V 472_M 1.637 1.00
324_R 328_R 1.634 0.99
429_F 450_R 1.617 0.99
344_L 411_I 1.6 0.99
424_K 433_Q 1.599 0.99
210_L 214_A 1.589 0.99
284_A 288_S 1.575 0.99
401_S 412_V 1.572 0.99
290_L 311_I 1.541 0.99
87_L 176_V 1.531 0.99
221_I 247_L 1.526 0.99
370_I 409_L 1.517 0.99
417_G 420_I 1.514 0.99
430_D 450_R 1.507 0.99
428_I 472_M 1.496 0.99
370_I 402_A 1.486 0.99
422_L 425_R 1.477 0.99
339_P 342_P 1.469 0.99
461_V 475_I 1.467 0.99
408_H 475_I 1.455 0.99
427_V 433_Q 1.454 0.99
387_L 413_V 1.453 0.99
291_R 308_L 1.448 0.98
287_Q 308_L 1.443 0.98
420_I 429_F 1.434 0.98
316_Q 377_N 1.424 0.98
425_R 429_F 1.416 0.98
429_F 462_A 1.396 0.98
231_L 238_L 1.388 0.98
238_L 259_K 1.385 0.98
424_K 427_V 1.376 0.98
424_K 435_V 1.375 0.98
222_E 225_A 1.371 0.98
429_F 433_Q 1.357 0.97
363_S 399_E 1.353 0.97
386_V 449_A 1.332 0.97
360_V 398_V 1.331 0.97
346_N 376_Q 1.321 0.97
307_M 311_I 1.317 0.97
378_D 381_E 1.314 0.97
344_L 413_V 1.308 0.97
211_W 215_W 1.307 0.97
383_M 387_L 1.299 0.96
337_L 373_V 1.291 0.96
386_V 413_V 1.264 0.96
461_V 473_E 1.264 0.96
383_M 474_V 1.263 0.96
421_P 435_V 1.255 0.95
224_L 251_V 1.249 0.95
397_F 416_D 1.242 0.95
420_I 470_A 1.241 0.95
453_T 476_F 1.23 0.95
89_Y 95_L 1.229 0.95
286_L 311_I 1.218 0.94
254_L 257_L 1.213 0.94
361_N 397_F 1.21 0.94
37_L 41_S 1.203 0.94
429_F 439_R 1.201 0.94
425_R 428_I 1.195 0.94
351_L 384_G 1.193 0.94
17_F 21_T 1.191 0.93
348_T 362_I 1.191 0.93
271_T 278_S 1.19 0.93
422_L 464_E 1.186 0.93
315_S 319_G 1.183 0.93
464_E 468_G 1.182 0.93
271_T 275_L 1.181 0.93
341_A 345_D 1.174 0.93
270_T 431_R 1.174 0.93
45_D 276_T 1.173 0.93
386_V 474_V 1.164 0.92
355_Y 398_V 1.162 0.92
321_Y 324_R 1.157 0.92
358_K 394_C 1.147 0.92
419_G 469_G 1.144 0.92
228_V 250_L 1.137 0.91
230_E 235_N 1.136 0.91
228_V 231_L 1.134 0.91
241_P 252_R 1.134 0.91
278_S 381_E 1.132 0.91
363_S 397_F 1.131 0.91
216_W 219_R 1.129 0.91
405_T 475_I 1.128 0.91
344_L 364_L 1.128 0.91
404_Q 478_R 1.125 0.91
403_R 410_Y 1.115 0.90
429_F 434_R 1.115 0.90
343_L 374_G 1.103 0.90
372_F 476_F 1.094 0.89
231_L 257_L 1.092 0.89
341_A 402_A 1.09 0.89
228_V 254_L 1.085 0.88
464_E 467_L 1.08 0.88
417_G 469_G 1.079 0.88
428_I 470_A 1.075 0.88
238_L 262_R 1.073 0.88
338_H 374_G 1.072 0.88
320_Y 378_D 1.072 0.88
262_R 266_D 1.068 0.87
355_Y 362_I 1.067 0.87
405_T 408_H 1.065 0.87
275_L 432_G 1.063 0.87
378_D 452_I 1.058 0.87
360_V 394_C 1.05 0.86
220_P 318_I 1.049 0.86
287_Q 291_R 1.043 0.86
415_D 470_A 1.039 0.85
276_T 285_V 1.038 0.85
289_T 306_V 1.035 0.85
415_D 420_I 1.034 0.85
239_L 255_N 1.034 0.85
341_A 366_I 1.02 0.84
228_V 310_Q 1.006 0.83
393_Y 418_P 1.005 0.83
56_S 159_V 1.003 0.83
265_Y 268_Y 1.003 0.83
272_L 378_D 1.002 0.82
285_V 288_S 1.001 0.82
420_I 433_Q 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.62961000.515Contact Map0.787
4ew8A20.52671000.607Contact Map0.751
3jz3A20.44031000.608Contact Map0.688
2btzA10.62761000.609Contact Map0.595
4e01A10.71191000.623Contact Map0.629
2c2aA10.48971000.627Contact Map0.736
2q8gA10.64811000.628Contact Map0.576
2e0aA20.63581000.629Contact Map0.621
1y8oA10.65431000.631Contact Map0.605
3d36A20.46711000.633Contact Map0.72

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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