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FEPC - Ferric enterobactin transport ATP-binding protein FepC
UniProt: P23878 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10295
Length: 271 (237)
Sequences: 69409
Seq/Len: 292.86

FEPC
Paralog alert: 0.94 [within 20: 0.84] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
37_A 211_A 3.337 1.00
9_R 29_E 3.101 1.00
34_H 213_H 3.094 1.00
136_L 139_Q 3.007 1.00
63_H 70_H 2.955 1.00
11_E 63_H 2.907 1.00
12_Q 25_N 2.893 1.00
21_T 24_E 2.749 1.00
36_T 215_I 2.724 1.00
129_Q 134_T 2.704 1.00
9_R 65_W 2.639 1.00
82_R 163_A 2.626 1.00
24_E 221_K 2.526 1.00
213_H 225_Q 2.451 1.00
31_P 34_H 2.443 1.00
10_G 13_L 2.315 1.00
14_T 25_N 2.303 1.00
226_G 230_E 2.272 1.00
16_G 21_T 2.26 1.00
123_A 161_E 2.192 1.00
98_V 144_L 2.17 1.00
15_L 52_T 2.152 1.00
14_T 21_T 2.149 1.00
67_D 163_A 2.102 1.00
14_T 61_H 2.077 1.00
227_A 230_E 2.026 1.00
128_M 137_A 1.994 1.00
125_T 137_A 1.989 1.00
11_E 65_W 1.93 1.00
99_Q 138_D 1.898 1.00
215_I 222_I 1.857 1.00
99_Q 137_A 1.853 1.00
32_D 163_A 1.821 1.00
188_E 192_E 1.8 1.00
99_Q 125_T 1.788 1.00
17_Y 22_V 1.788 1.00
130_A 188_E 1.777 1.00
161_E 195_Y 1.771 1.00
12_Q 27_T 1.768 1.00
34_H 212_S 1.758 1.00
215_I 225_Q 1.715 1.00
15_L 60_A 1.678 1.00
99_Q 124_V 1.617 1.00
126_K 130_A 1.581 1.00
88_Q 146_G 1.571 1.00
16_G 60_A 1.513 1.00
121_E 125_T 1.507 1.00
50_L 200_V 1.5 1.00
139_Q 143_T 1.484 1.00
123_A 126_K 1.479 1.00
190_N 212_S 1.446 1.00
99_Q 103_A 1.444 1.00
23_A 52_T 1.431 1.00
28_V 215_I 1.422 1.00
11_E 29_E 1.419 1.00
226_G 231_I 1.418 1.00
99_Q 121_E 1.409 1.00
65_W 70_H 1.409 1.00
130_A 192_E 1.399 0.99
30_I 36_T 1.38 0.99
15_L 57_M 1.354 0.99
130_A 193_K 1.347 0.99
10_G 53_L 1.346 0.99
201_L 207_A 1.345 0.99
102_V 159_A 1.334 0.99
134_T 137_A 1.327 0.99
103_A 124_V 1.314 0.99
122_E 126_K 1.311 0.99
67_D 82_R 1.309 0.99
167_L 186_L 1.298 0.99
52_T 59_P 1.297 0.99
50_L 166_L 1.288 0.99
14_T 24_E 1.287 0.99
36_T 225_Q 1.268 0.99
125_T 129_Q 1.264 0.99
10_G 28_V 1.262 0.99
101_L 156_M 1.249 0.99
97_T 100_E 1.237 0.98
7_R 67_D 1.215 0.98
11_E 27_T 1.207 0.98
98_V 152_A 1.207 0.98
136_L 148_Q 1.201 0.98
125_T 134_T 1.201 0.98
123_A 127_A 1.198 0.98
75_A 78_E 1.188 0.98
13_L 59_P 1.185 0.98
10_G 49_L 1.172 0.98
35_F 190_N 1.165 0.97
31_P 213_H 1.16 0.97
49_L 217_L 1.155 0.97
51_R 57_M 1.145 0.97
53_L 198_A 1.119 0.96
187_S 190_N 1.117 0.96
190_N 197_L 1.115 0.96
69_E 82_R 1.114 0.96
70_H 73_H 1.109 0.96
15_L 48_T 1.104 0.96
179_Q 206_Q 1.091 0.96
163_A 195_Y 1.083 0.96
36_T 213_H 1.076 0.95
185_L 188_E 1.073 0.95
35_F 197_L 1.07 0.95
17_Y 48_T 1.067 0.95
218_R 223_V 1.066 0.95
16_G 22_V 1.06 0.95
54_S 85_L 1.059 0.95
32_D 67_D 1.059 0.95
103_A 120_D 1.059 0.95
52_T 64_V 1.053 0.95
86_L 167_L 1.05 0.94
189_L 195_Y 1.049 0.94
131_T 155_A 1.048 0.94
126_K 161_E 1.047 0.94
127_A 155_A 1.044 0.94
128_M 133_I 1.043 0.94
38_I 49_L 1.042 0.94
127_A 159_A 1.037 0.94
26_L 49_L 1.036 0.94
103_A 121_E 1.036 0.94
183_L 206_Q 1.032 0.94
144_L 152_A 1.03 0.94
126_K 129_Q 1.023 0.93
86_L 154_I 1.02 0.93
96_I 100_E 1.02 0.93
132_G 181_D 1.02 0.93
54_S 166_L 1.02 0.93
84_G 162_T 1.013 0.93
165_M 197_L 1.004 0.93
140_S 143_T 1.003 0.93
12_Q 61_H 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2yyzA10.96311000.078Contact Map0.803
2it1A20.96311000.08Contact Map0.857
1oxxK10.97051000.081Contact Map0.793
1g29120.97051000.082Contact Map0.882
3fvqA20.97421000.082Contact Map0.769
3tuiC40.98521000.083Contact Map0.869
1v43A10.97791000.083Contact Map0.823
1g6hA10.89671000.084Contact Map0.82
1z47A20.97791000.087Contact Map0.831
3rlfA20.96311000.087Contact Map0.827

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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