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CYDC - ATP-binding/permease protein CydC
UniProt: P23886 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10012
Length: 573 (567)
Sequences: 20191
Seq/Len: 35.61

CYDC
Paralog alert: 0.94 [within 20: 0.60] - ratio of genomes with paralogs
Cluster includes: CYDC CYDD MDLA MDLB MSBA YDDA YOJI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
343_D 358_G 5.491 1.00
456_E 464_L 5.328 1.00
367_E 541_Q 4.909 1.00
364_N 367_E 4.72 1.00
340_T 362_Q 4.674 1.00
342_R 396_E 4.468 1.00
556_H 566_Y 4.263 1.00
431_R 443_D 4.16 1.00
428_A 432_D 4.114 1.00
541_Q 553_Q 3.995 1.00
342_R 398_L 3.852 1.00
451_R 456_E 3.84 1.00
456_E 460_E 3.715 1.00
396_E 403_P 3.653 1.00
357_K 549_Q 3.552 1.00
442_S 445_A 3.475 1.00
338_S 362_Q 3.47 1.00
345_Q 358_G 3.461 1.00
431_R 465_N 3.426 1.00
450_L 464_L 3.246 1.00
563_Q 567_Y 3.221 1.00
431_R 435_L 3.155 1.00
341_L 344_V 3.131 1.00
383_L 529_V 3.089 1.00
438_S 445_A 3.022 1.00
443_D 447_S 3.006 1.00
434_L 450_L 2.931 1.00
417_S 493_A 2.813 1.00
383_L 497_L 2.781 1.00
448_E 452_R 2.775 1.00
361_L 543_I 2.73 1.00
555_T 558_E 2.695 1.00
431_R 446_L 2.686 1.00
447_S 451_R 2.669 1.00
340_T 398_L 2.652 1.00
363_V 369_I 2.641 1.00
388_R 391_D 2.64 1.00
552_E 564_G 2.586 1.00
434_L 446_L 2.572 1.00
338_S 364_N 2.518 1.00
415_T 494_P 2.466 1.00
408_N 411_A 2.441 1.00
447_S 456_E 2.437 1.00
552_E 563_Q 2.425 1.00
338_S 365_A 2.398 1.00
354_Q 357_K 2.395 1.00
462_A 466_S 2.363 1.00
455_L 458_L 2.357 1.00
543_I 553_Q 2.298 1.00
341_L 361_L 2.297 1.00
391_D 405_A 2.281 1.00
368_H 539_F 2.271 1.00
345_Q 394_Q 2.264 1.00
435_L 446_L 2.212 1.00
492_D 524_K 2.209 1.00
447_S 460_E 2.207 1.00
552_E 562_R 2.188 1.00
448_E 451_R 2.181 1.00
518_A 538_R 2.138 1.00
369_I 541_Q 2.046 1.00
345_Q 354_Q 2.027 1.00
343_D 360_S 2.013 1.00
6_P 319_D 1.995 1.00
347_T 393_Q 1.99 1.00
363_V 527_L 1.988 1.00
435_L 443_D 1.98 1.00
450_L 459_L 1.978 1.00
339_L 527_L 1.975 1.00
546_D 565_R 1.97 1.00
554_G 558_E 1.964 1.00
356_L 359_I 1.956 1.00
347_T 354_Q 1.944 1.00
449_I 453_V 1.936 1.00
153_I 157_F 1.936 1.00
10_L 98_Y 1.909 1.00
371_I 382_L 1.866 1.00
403_P 406_S 1.863 1.00
337_V 400_N 1.851 1.00
551_I 565_R 1.843 1.00
218_A 221_R 1.801 1.00
543_I 550_I 1.789 1.00
445_A 492_D 1.787 1.00
444_E 447_S 1.782 1.00
567_Y 571_Q 1.782 1.00
315_S 319_D 1.773 1.00
552_E 567_Y 1.738 1.00
369_I 543_I 1.717 1.00
530_T 535_G 1.696 1.00
510_E 532_R 1.686 1.00
457_K 460_E 1.682 1.00
126_D 313_R 1.666 1.00
358_G 549_Q 1.651 1.00
382_L 545_M 1.649 1.00
447_S 464_L 1.649 1.00
346_F 381_T 1.641 1.00
445_A 448_E 1.635 1.00
102_K 106_L 1.635 1.00
368_H 528_M 1.621 1.00
454_G 512_Q 1.62 1.00
159_D 269_G 1.615 1.00
537_S 557_A 1.613 1.00
443_D 465_N 1.612 1.00
371_I 543_I 1.607 1.00
430_L 483_L 1.604 1.00
392_P 404_I 1.601 1.00
40_G 44_S 1.581 1.00
156_S 163_A 1.569 1.00
441_S 490_L 1.566 1.00
367_E 540_Q 1.554 1.00
452_R 519_E 1.551 1.00
450_L 456_E 1.55 1.00
546_D 551_I 1.542 1.00
469_G 474_Q 1.541 1.00
560_L 570_K 1.533 1.00
519_E 522_R 1.531 1.00
326_F 408_N 1.516 1.00
195_L 232_Q 1.51 1.00
505_L 513_I 1.504 1.00
399_L 495_L 1.496 1.00
511_S 515_E 1.495 1.00
14_H 94_H 1.493 1.00
12_K 15_K 1.48 1.00
190_Q 312_V 1.472 1.00
397_I 404_I 1.466 1.00
387_T 418_V 1.466 1.00
462_A 467_W 1.457 1.00
264_W 268_G 1.453 1.00
268_G 272_G 1.45 1.00
558_E 562_R 1.442 1.00
459_L 464_L 1.434 1.00
102_K 322_P 1.426 1.00
364_N 541_Q 1.42 1.00
434_L 490_L 1.415 1.00
346_F 390_W 1.413 1.00
44_S 276_P 1.413 1.00
449_I 489_L 1.412 1.00
443_D 446_L 1.411 1.00
359_I 550_I 1.406 0.99
435_L 441_S 1.4 0.99
374_R 565_R 1.399 0.99
338_S 400_N 1.396 0.99
438_S 441_S 1.394 0.99
468_L 475_L 1.393 0.99
361_L 382_L 1.389 0.99
209_G 424_H 1.378 0.99
417_S 488_A 1.372 0.99
530_T 536_L 1.363 0.99
515_E 519_E 1.363 0.99
370_A 539_F 1.358 0.99
112_A 390_W 1.356 0.99
455_L 459_L 1.356 0.99
198_Q 232_Q 1.354 0.99
156_S 160_F 1.353 0.99
359_I 382_L 1.353 0.99
427_S 467_W 1.343 0.99
375_T 509_T 1.333 0.99
452_R 489_L 1.327 0.99
327_P 406_S 1.32 0.99
385_Q 397_I 1.315 0.99
445_A 490_L 1.313 0.99
336_R 400_N 1.312 0.99
542_I 556_H 1.3 0.99
44_S 278_A 1.293 0.99
374_R 546_D 1.291 0.99
222_Y 436_L 1.29 0.99
340_T 401_D 1.282 0.99
36_L 44_S 1.268 0.99
458_L 479_E 1.268 0.99
224_T 228_N 1.267 0.99
346_F 385_Q 1.256 0.99
441_S 445_A 1.253 0.99
344_V 392_P 1.25 0.99
99_T 317_L 1.242 0.98
565_R 568_Q 1.235 0.98
545_M 550_I 1.23 0.98
339_L 399_L 1.227 0.98
462_A 465_N 1.217 0.98
370_A 536_L 1.213 0.98
460_E 463_G 1.212 0.98
184_A 187_S 1.208 0.98
557_A 561_A 1.208 0.98
105_P 322_P 1.206 0.98
521_M 526_V 1.205 0.98
214_T 219_S 1.199 0.98
429_T 432_D 1.198 0.98
342_R 360_S 1.196 0.98
345_Q 357_K 1.195 0.98
102_K 318_T 1.193 0.98
220_D 224_T 1.19 0.98
202_Q 229_T 1.183 0.98
450_L 455_L 1.179 0.98
447_S 450_L 1.179 0.98
341_L 386_L 1.176 0.98
402_S 406_S 1.169 0.97
369_I 527_L 1.165 0.97
386_L 527_L 1.154 0.97
129_T 310_S 1.153 0.97
340_T 396_E 1.149 0.97
434_L 483_L 1.149 0.97
206_W 222_Y 1.148 0.97
343_D 394_Q 1.148 0.97
265_M 269_G 1.142 0.97
368_H 526_V 1.139 0.97
226_L 230_E 1.132 0.97
431_R 464_L 1.131 0.97
392_P 397_I 1.129 0.97
454_G 509_T 1.126 0.97
195_L 236_A 1.121 0.97
444_E 448_E 1.121 0.97
442_S 490_L 1.12 0.96
326_F 409_E 1.12 0.96
409_E 413_R 1.116 0.96
469_G 472_G 1.11 0.96
340_T 360_S 1.109 0.96
115_R 118_E 1.104 0.96
460_E 464_L 1.102 0.96
162_L 283_F 1.101 0.96
222_Y 225_Q 1.098 0.96
419_V 488_A 1.097 0.96
160_F 164_F 1.095 0.96
363_V 525_T 1.095 0.96
477_G 482_R 1.088 0.96
556_H 560_L 1.087 0.96
402_S 407_L 1.082 0.96
338_S 401_D 1.079 0.95
341_L 382_L 1.075 0.95
449_I 490_L 1.071 0.95
419_V 485_I 1.065 0.95
155_L 283_F 1.065 0.95
475_L 483_L 1.061 0.95
454_G 515_E 1.058 0.95
195_L 198_Q 1.056 0.95
344_V 385_Q 1.053 0.95
269_G 274_A 1.051 0.94
118_E 197_G 1.05 0.94
448_E 492_D 1.049 0.94
102_K 105_P 1.044 0.94
176_L 180_L 1.035 0.94
396_E 405_A 1.033 0.94
112_A 384_Q 1.032 0.94
327_P 330_Q 1.03 0.94
468_L 474_Q 1.03 0.94
399_L 412_L 1.017 0.93
114_Y 118_E 1.009 0.93
431_R 447_S 1.007 0.93
432_D 435_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qf4B10.98951000.116Contact Map0.732
4a82A40.99481000.122Contact Map0.079
3b5xA20.98951000.125Contact Map0.104
3b60A40.98951000.125Contact Map0.761
4f4cA10.99831000.128Contact Map0.731
3qf4A10.99131000.133Contact Map0.751
2yl4A10.99651000.133Contact Map0.717
3g5uA20.99831000.142Contact Map0.687
3nh6A10.49911000.414Contact Map0.79
3vx4A20.46251000.479Contact Map0.843

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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