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GSA - Glutamate-1-semialdehyde 2,1-aminomutase
UniProt: P23893 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10432
Length: 426 (422)
Sequences: 9800
Seq/Len: 23.22

GSA
Paralog alert: 0.89 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_I 80_E 4.824 1.00
389_E 421_R 4.472 1.00
224_R 228_D 4.365 1.00
43_Y 51_A 3.976 1.00
330_R 413_N 3.824 1.00
184_L 222_G 3.764 1.00
319_G 322_E 3.565 1.00
98_L 313_N 3.435 1.00
38_K 45_Y 3.369 1.00
73_N 77_E 3.137 1.00
247_L 253_Y 3.065 1.00
330_R 409_M 3.049 1.00
70_A 317_Q 2.967 1.00
408_S 411_D 2.931 1.00
341_E 420_R 2.897 1.00
323_T 327_L 2.809 1.00
70_A 310_A 2.714 1.00
310_A 313_N 2.632 1.00
326_E 409_M 2.607 1.00
222_G 225_A 2.493 1.00
225_A 229_E 2.471 1.00
98_L 316_A 2.466 1.00
334_G 416_I 2.435 1.00
37_E 47_V 2.415 1.00
55_Y 415_T 2.372 1.00
385_M 388_D 2.356 1.00
70_A 314_E 2.355 1.00
188_R 229_E 2.341 1.00
68_H 314_E 2.321 1.00
329_T 333_E 2.302 1.00
202_I 235_I 2.284 1.00
43_Y 411_D 2.276 1.00
389_E 425_K 2.221 1.00
10_A 97_Q 2.115 1.00
391_V 418_A 2.098 1.00
45_Y 51_A 2.051 1.00
332_A 336_L 2.02 1.00
37_E 81_R 2.006 1.00
385_M 389_E 1.984 1.00
75_V 307_A 1.968 1.00
90_E 94_K 1.959 1.00
98_L 309_F 1.957 1.00
414_N 418_A 1.956 1.00
342_A 420_R 1.931 1.00
72_R 76_I 1.931 1.00
203_V 223_L 1.931 1.00
187_V 223_L 1.915 1.00
112_V 274_G 1.908 1.00
108_M 280_R 1.9 1.00
334_G 413_N 1.894 1.00
97_Q 101_E 1.89 1.00
134_K 197_E 1.889 1.00
95_M 308_G 1.887 1.00
334_G 417_D 1.875 1.00
385_M 425_K 1.873 1.00
334_G 337_E 1.858 1.00
201_I 227_C 1.856 1.00
138_F 219_F 1.84 1.00
96_A 111_M 1.84 1.00
314_E 318_P 1.83 1.00
46_D 50_K 1.828 1.00
280_R 284_D 1.827 1.00
75_V 79_A 1.811 1.00
40_D 69_P 1.797 1.00
50_K 390_G 1.793 1.00
119_T 262_C 1.744 1.00
51_A 414_N 1.707 1.00
263_L 275_A 1.683 1.00
107_D 280_R 1.682 1.00
43_Y 414_N 1.67 1.00
323_T 326_E 1.637 1.00
332_A 350_H 1.631 1.00
322_E 326_E 1.624 1.00
218_E 221_P 1.61 1.00
77_E 81_R 1.587 1.00
188_R 192_E 1.584 1.00
263_L 277_G 1.583 1.00
129_F 282_V 1.579 1.00
247_L 325_D 1.576 1.00
94_K 309_F 1.567 1.00
180_T 186_S 1.567 1.00
98_L 101_E 1.557 1.00
73_N 76_I 1.55 1.00
268_G 273_V 1.548 1.00
122_A 262_C 1.538 1.00
69_P 73_N 1.538 1.00
247_L 252_D 1.528 1.00
327_L 412_I 1.522 1.00
327_L 330_R 1.522 1.00
191_F 232_A 1.52 1.00
342_A 424_A 1.519 1.00
236_I 251_Q 1.519 1.00
36_I 44_L 1.504 1.00
74_A 310_A 1.492 1.00
224_R 234_L 1.491 1.00
267_I 273_V 1.482 1.00
103_V 277_G 1.479 1.00
126_A 235_I 1.473 1.00
310_A 314_E 1.471 1.00
38_K 81_R 1.468 1.00
46_D 52_Y 1.462 1.00
42_A 411_D 1.46 1.00
185_A 188_R 1.453 1.00
121_S 276_F 1.453 1.00
224_R 227_C 1.436 1.00
182_N 216_L 1.434 1.00
67_N 72_R 1.427 1.00
385_M 422_V 1.424 1.00
180_T 183_D 1.414 1.00
68_H 318_P 1.41 1.00
201_I 223_L 1.404 0.99
102_L 316_A 1.403 0.99
123_I 135_I 1.389 0.99
327_L 409_M 1.385 0.99
203_V 220_L 1.385 0.99
188_R 222_G 1.384 0.99
260_L 278_G 1.382 0.99
40_D 67_N 1.382 0.99
409_M 413_N 1.38 0.99
338_A 416_I 1.378 0.99
75_V 303_I 1.374 0.99
273_V 305_M 1.369 0.99
42_A 406_A 1.368 0.99
40_D 51_A 1.368 0.99
109_V 277_G 1.367 0.99
407_H 412_I 1.366 0.99
218_E 254_Y 1.365 0.99
94_K 313_N 1.363 0.99
389_E 422_V 1.355 0.99
100_T 109_V 1.348 0.99
236_I 256_V 1.348 0.99
332_A 355_F 1.345 0.99
136_I 198_I 1.338 0.99
309_F 313_N 1.337 0.99
221_P 225_A 1.337 0.99
132_R 231_G 1.328 0.99
386_M 393_L 1.328 0.99
330_R 334_G 1.324 0.99
336_L 339_A 1.32 0.99
43_Y 53_I 1.319 0.99
254_Y 351_V 1.318 0.99
119_T 202_I 1.316 0.99
77_E 80_E 1.307 0.99
420_R 424_A 1.292 0.99
273_V 308_G 1.285 0.99
233_L 282_V 1.271 0.99
334_G 420_R 1.269 0.99
185_A 189_A 1.268 0.99
76_I 79_A 1.268 0.99
257_V 279_R 1.268 0.99
108_M 284_D 1.261 0.99
129_F 285_A 1.254 0.99
223_L 234_L 1.245 0.98
72_R 79_A 1.239 0.98
189_A 193_Q 1.238 0.98
134_K 177_L 1.236 0.98
313_N 317_Q 1.234 0.98
417_D 421_R 1.23 0.98
64_L 314_E 1.23 0.98
248_A 252_D 1.229 0.98
251_Q 261_T 1.218 0.98
386_M 391_V 1.216 0.98
72_R 80_E 1.214 0.98
267_I 275_A 1.21 0.98
101_E 316_A 1.207 0.98
411_D 414_N 1.206 0.98
333_E 337_E 1.196 0.98
135_I 200_C 1.18 0.98
389_E 418_A 1.179 0.98
315_V 321_H 1.171 0.98
367_C 370_D 1.169 0.97
346_L 360_T 1.166 0.97
225_A 228_D 1.163 0.97
413_N 417_D 1.145 0.97
253_Y 351_V 1.142 0.97
260_L 276_F 1.141 0.97
386_M 422_V 1.14 0.97
315_V 320_V 1.14 0.97
112_V 276_F 1.136 0.97
37_E 49_G 1.132 0.97
321_H 324_L 1.124 0.97
338_A 420_R 1.122 0.97
188_R 230_F 1.115 0.96
221_P 255_G 1.113 0.96
206_V 351_V 1.105 0.96
71_I 307_A 1.102 0.96
386_M 418_A 1.093 0.96
246_A 252_D 1.091 0.96
414_N 417_D 1.088 0.96
179_C 190_A 1.079 0.95
10_A 14_L 1.079 0.95
184_L 226_L 1.075 0.95
42_A 53_I 1.074 0.95
111_M 305_M 1.073 0.95
325_D 329_T 1.071 0.95
116_T 146_A 1.07 0.95
118_A 262_C 1.065 0.95
271_M 304_A 1.064 0.95
243_F 315_V 1.058 0.95
95_M 309_F 1.056 0.95
188_R 226_L 1.056 0.95
64_L 311_C 1.054 0.95
191_F 198_I 1.054 0.95
391_V 415_T 1.053 0.95
269_G 311_C 1.051 0.94
226_L 230_F 1.048 0.94
125_L 276_F 1.045 0.94
314_E 317_Q 1.038 0.94
188_R 225_A 1.036 0.94
109_V 275_A 1.028 0.94
381_R 385_M 1.025 0.93
192_E 230_F 1.024 0.93
207_A 210_M 1.021 0.93
186_S 189_A 1.018 0.93
410_E 413_N 1.018 0.93
102_L 248_A 1.018 0.93
322_E 325_D 1.014 0.93
36_I 39_A 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a0gA40.97891000.335Contact Map0.583
2epjA10.99061000.336Contact Map0.706
4e77A111000.356Contact Map0.696
4ao9A20.94841000.379Contact Map0.628
2ykyA30.94841000.386Contact Map0.649
3tfuA20.94371000.398Contact Map0.708
3k28A40.99531000.401Contact Map0.787
2e7uA10.98831000.403Contact Map0.709
2cy8A10.98121000.412Contact Map0.648
3oksA40.95541000.412Contact Map0.721

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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