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ARGE - Acetylornithine deacetylase
UniProt: P23908 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11286
Length: 383 (377)
Sequences: 12823
Seq/Len: 34.01

ARGE
Paralog alert: 0.89 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: ABGA ABGB ALLC ARGE DAPE PEPT YGEY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
188_R 256_C 3.345 1.00
40_A 44_K 3.209 1.00
194_G 202_G 3.195 1.00
67_S 137_Y 3.176 1.00
188_R 258_E 2.955 1.00
279_N 283_A 2.806 1.00
189_I 212_A 2.762 1.00
276_G 280_D 2.744 1.00
275_N 279_N 2.698 1.00
319_K 379_H 2.676 1.00
208_L 291_G 2.645 1.00
190_Q 292_R 2.64 1.00
104_K 360_Y 2.632 1.00
186_A 258_E 2.616 1.00
209_M 244_I 2.603 1.00
42_W 45_D 2.542 1.00
14_A 38_L 2.54 1.00
74_G 135_P 2.532 1.00
92_T 358_D 2.502 1.00
188_R 294_T 2.495 1.00
190_Q 256_C 2.475 1.00
209_M 257_C 2.39 1.00
209_M 259_L 2.354 1.00
40_A 52_V 2.351 1.00
186_A 296_D 2.27 1.00
41_D 45_D 2.266 1.00
375_Q 378_H 2.262 1.00
245_H 258_E 2.198 1.00
186_A 260_H 2.198 1.00
14_A 27_A 2.175 1.00
126_D 374_T 2.162 1.00
37_T 41_D 2.148 1.00
210_H 213_I 2.139 1.00
46_L 125_R 2.13 1.00
39_L 81_T 2.078 1.00
190_Q 294_T 2.013 1.00
246_G 257_C 2.008 1.00
43_F 66_A 2.004 1.00
152_R 156_E 2 1.00
93_R 101_H 1.979 1.00
38_L 42_W 1.942 1.00
277_L 280_D 1.878 1.00
212_A 282_L 1.877 1.00
272_N 276_G 1.87 1.00
192_Q 203_V 1.858 1.00
103_G 364_R 1.851 1.00
94_D 97_T 1.829 1.00
320_L 375_Q 1.823 1.00
318_E 324_K 1.822 1.00
8_F 370_R 1.8 1.00
74_G 137_Y 1.778 1.00
93_R 97_T 1.777 1.00
67_S 135_P 1.723 1.00
119_F 369_T 1.716 1.00
203_V 208_L 1.71 1.00
243_H 260_H 1.703 1.00
37_T 52_V 1.689 1.00
211_D 214_G 1.674 1.00
153_Y 156_E 1.668 1.00
18_T 38_L 1.664 1.00
283_A 287_E 1.652 1.00
205_A 257_C 1.638 1.00
338_Q 343_T 1.636 1.00
14_A 17_A 1.634 1.00
270_T 273_E 1.633 1.00
193_S 255_A 1.622 1.00
44_K 52_V 1.622 1.00
76_L 162_P 1.615 1.00
41_D 44_K 1.608 1.00
8_F 122_D 1.604 1.00
125_R 129_V 1.601 1.00
42_W 46_L 1.599 1.00
48_F 68_I 1.596 1.00
40_A 64_M 1.595 1.00
10_E 14_A 1.595 1.00
206_I 244_I 1.589 1.00
273_E 277_L 1.588 1.00
210_H 214_G 1.587 1.00
76_L 139_L 1.587 1.00
77_L 120_I 1.584 1.00
7_P 125_R 1.58 1.00
189_I 209_M 1.576 1.00
286_S 293_L 1.567 1.00
126_D 130_T 1.564 1.00
211_D 289_W 1.506 1.00
40_A 50_V 1.503 1.00
36_I 81_T 1.49 1.00
223_L 277_L 1.488 1.00
13_R 17_A 1.478 1.00
44_K 50_V 1.468 1.00
38_L 41_D 1.449 1.00
188_R 296_D 1.437 1.00
68_I 128_D 1.413 1.00
8_F 118_A 1.408 1.00
16_I 107_G 1.405 0.99
22_S 146_T 1.402 0.99
20_S 35_L 1.399 0.99
367_K 371_E 1.387 0.99
203_V 291_G 1.386 0.99
11_I 42_W 1.382 0.99
368_P 371_E 1.371 0.99
273_E 276_G 1.366 0.99
189_I 208_L 1.361 0.99
375_Q 379_H 1.355 0.99
11_I 38_L 1.346 0.99
120_I 138_I 1.343 0.99
235_P 267_P 1.333 0.99
187_I 259_L 1.332 0.99
207_E 217_L 1.328 0.99
282_L 293_L 1.327 0.99
319_K 375_Q 1.325 0.99
206_I 246_G 1.325 0.99
237_P 274_L 1.323 0.99
183_I 271_L 1.32 0.99
14_A 18_T 1.313 0.99
100_E 363_T 1.312 0.99
49_N 67_S 1.308 0.99
13_R 100_E 1.306 0.99
26_E 62_F 1.299 0.99
79_G 113_M 1.298 0.99
6_P 10_E 1.291 0.99
17_A 97_T 1.29 0.99
17_A 100_E 1.28 0.99
213_I 259_L 1.276 0.99
164_C 380_F 1.268 0.99
280_D 284_P 1.265 0.99
185_N 261_M 1.262 0.99
13_R 363_T 1.259 0.99
77_L 377_I 1.258 0.99
10_E 13_R 1.251 0.99
364_R 368_P 1.251 0.99
76_L 165_A 1.25 0.99
207_E 218_Q 1.237 0.98
13_R 98_L 1.234 0.98
187_I 212_A 1.229 0.98
16_I 110_T 1.228 0.98
276_G 279_N 1.225 0.98
211_D 288_R 1.219 0.98
15_L 38_L 1.201 0.98
153_Y 157_T 1.199 0.98
123_A 374_T 1.193 0.98
244_I 257_C 1.19 0.98
42_W 125_R 1.188 0.98
39_L 117_F 1.167 0.97
11_I 122_D 1.166 0.97
9_I 13_R 1.155 0.97
27_A 37_T 1.151 0.97
103_G 362_E 1.151 0.97
36_I 64_M 1.149 0.97
37_T 40_A 1.148 0.97
104_K 362_E 1.144 0.97
185_N 275_N 1.138 0.97
215_H 284_P 1.135 0.97
315_E 318_E 1.134 0.97
50_V 66_A 1.134 0.97
189_I 259_L 1.123 0.97
79_G 117_F 1.117 0.96
279_N 295_V 1.116 0.96
362_E 365_F 1.115 0.96
17_A 98_L 1.1 0.96
316_V 379_H 1.1 0.96
207_E 213_I 1.09 0.96
215_H 218_Q 1.084 0.96
198_D 201_R 1.08 0.95
126_D 371_E 1.074 0.95
213_I 244_I 1.072 0.95
68_I 138_I 1.069 0.95
130_T 378_H 1.057 0.95
88_D 94_D 1.053 0.95
190_Q 255_A 1.051 0.94
215_H 281_A 1.04 0.94
371_E 375_Q 1.036 0.94
115_G 366_I 1.03 0.94
152_R 336_F 1.026 0.94
213_I 241_L 1.018 0.93
70_Q 133_K 1.013 0.93
216_I 278_L 1.012 0.93
214_G 218_Q 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pfoA20.97651000.198Contact Map0.736
1vgyA20.93991000.226Contact Map0.719
3iszA20.93211000.236Contact Map0.801
3tx8A10.92171000.239Contact Map0.622
1cg2A40.94521000.242Contact Map0.702
2f7vA10.92171000.248Contact Map0.57
3ct9A20.9061000.249Contact Map0.681
3rzaA20.92691000.251Contact Map0.733
3gb0A10.92171000.255Contact Map0.738
4g1pA10.99221000.271Contact Map0.694

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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