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ACRE - Acriflavine resistance protein E
UniProt: P24180 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10266
Length: 385 (355)
Sequences: 9879
Seq/Len: 27.83

ACRE
Paralog alert: 0.77 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_N 94_Q 3.242 1.00
337_V 350_E 3.129 1.00
91_S 174_K 3.074 1.00
87_Q 180_S 3 1.00
326_N 332_E 2.929 1.00
334_R 356_D 2.875 1.00
122_H 126_K 2.845 1.00
108_K 167_R 2.723 1.00
43_I 357_Q 2.643 1.00
257_G 277_A 2.568 1.00
129_V 133_G 2.466 1.00
321_T 333_A 2.463 1.00
129_V 146_I 2.375 1.00
46_T 354_S 2.367 1.00
60_N 214_D 2.365 1.00
242_N 256_K 2.354 1.00
104_Y 163_V 2.321 1.00
128_Y 137_I 2.292 1.00
115_E 160_K 2.25 1.00
324_I 334_R 2.242 1.00
146_I 150_R 2.223 1.00
59_T 213_V 2.191 1.00
260_Q 278_V 2.169 1.00
94_Q 174_K 2.16 1.00
87_Q 90_Q 2.158 1.00
70_Q 172_Y 2.157 1.00
309_Q 346_W 2.136 1.00
97_P 101_Q 2.119 1.00
122_H 153_D 2.08 1.00
128_Y 145_A 2.079 1.00
330_Q 371_Q 2.078 1.00
79_N 94_Q 2.072 1.00
306_L 345_K 2.027 1.00
139_Q 143_D 2.018 1.00
132_V 142_Y 1.99 1.00
91_S 176_T 1.979 1.00
79_N 91_S 1.966 1.00
215_V 294_A 1.948 1.00
44_V 355_G 1.93 1.00
177_A 205_V 1.897 1.00
46_T 303_D 1.893 1.00
47_A 345_K 1.885 1.00
339_S 349_S 1.875 1.00
353_K 356_D 1.873 1.00
184_G 206_Q 1.847 1.00
325_V 372_V 1.833 1.00
88_A 180_S 1.829 1.00
75_V 188_V 1.827 1.00
125_V 142_Y 1.81 1.00
118_A 149_A 1.801 1.00
47_A 306_L 1.798 1.00
339_S 347_L 1.785 1.00
215_V 277_A 1.773 1.00
85_D 182_R 1.769 1.00
332_E 368_P 1.766 1.00
331_V 359_I 1.756 1.00
105_D 108_K 1.755 1.00
149_A 153_D 1.729 1.00
337_V 349_S 1.713 1.00
212_Y 276_R 1.708 1.00
336_V 348_I 1.691 1.00
157_I 160_K 1.685 1.00
244_E 295_R 1.678 1.00
132_V 139_Q 1.665 1.00
164_E 167_R 1.662 1.00
125_V 129_V 1.659 1.00
111_L 156_V 1.657 1.00
324_I 356_D 1.633 1.00
120_I 124_T 1.628 1.00
113_K 155_A 1.627 1.00
101_Q 105_D 1.622 1.00
150_R 153_D 1.594 1.00
244_E 256_K 1.593 1.00
111_L 163_V 1.591 1.00
322_V 336_V 1.584 1.00
319_D 335_P 1.577 1.00
338_A 346_W 1.573 1.00
75_V 93_Y 1.573 1.00
48_P 302_P 1.568 1.00
243_V 277_A 1.557 1.00
44_V 305_I 1.532 1.00
125_V 149_A 1.52 1.00
73_G 95_I 1.512 1.00
112_A 115_E 1.505 1.00
245_L 279_F 1.497 1.00
122_H 149_A 1.495 1.00
141_E 144_Q 1.49 1.00
52_K 295_R 1.49 1.00
340_Q 347_L 1.475 1.00
214_D 274_T 1.474 1.00
126_K 129_V 1.452 1.00
59_T 211_I 1.449 1.00
115_E 119_A 1.445 1.00
81_T 84_S 1.44 1.00
301_Q 347_L 1.419 1.00
63_R 207_Q 1.417 1.00
160_K 164_E 1.415 1.00
218_S 221_D 1.412 1.00
41_V 325_V 1.412 1.00
207_Q 210_P 1.406 0.99
183_I 203_A 1.401 0.99
307_I 358_V 1.388 0.99
118_A 122_H 1.374 0.99
305_I 354_S 1.361 0.99
100_Y 173_T 1.36 0.99
92_L 203_A 1.358 0.99
101_Q 170_L 1.354 0.99
54_E 293_R 1.351 0.99
213_V 294_A 1.349 0.99
38_Q 373_K 1.329 0.99
144_Q 148_D 1.314 0.99
41_V 374_A 1.311 0.99
41_V 357_Q 1.304 0.99
42_H 360_V 1.288 0.99
309_Q 344_D 1.278 0.99
213_V 292_V 1.272 0.99
21_I 24_C 1.271 0.99
253_Y 285_T 1.267 0.99
119_A 122_H 1.265 0.99
315_T 333_A 1.265 0.99
64_I 204_T 1.263 0.99
54_E 295_R 1.254 0.99
77_N 190_E 1.253 0.99
244_E 254_P 1.253 0.99
104_Y 108_K 1.245 0.98
242_N 258_T 1.233 0.98
66_E 201_E 1.222 0.98
142_Y 146_I 1.221 0.98
78_R 190_E 1.217 0.98
106_S 162_T 1.208 0.98
258_T 278_V 1.205 0.98
153_D 157_I 1.204 0.98
348_I 352_L 1.204 0.98
48_P 303_D 1.186 0.98
216_T 274_T 1.185 0.98
359_I 366_A 1.182 0.98
108_K 112_A 1.178 0.98
326_N 330_Q 1.155 0.97
266_V 273_I 1.154 0.97
127_R 143_D 1.151 0.97
259_L 275_L 1.148 0.97
43_I 355_G 1.14 0.97
76_L 96_D 1.138 0.97
111_L 115_E 1.135 0.97
177_A 180_S 1.134 0.97
109_G 161_A 1.133 0.97
80_F 90_Q 1.13 0.97
119_A 150_R 1.123 0.97
304_A 347_L 1.122 0.97
129_V 142_Y 1.121 0.97
307_I 322_V 1.111 0.96
91_S 94_Q 1.111 0.96
125_V 146_I 1.108 0.96
186_S 189_T 1.107 0.96
93_Y 203_A 1.107 0.96
72_S 196_N 1.1 0.96
103_N 106_S 1.097 0.96
179_I 205_V 1.095 0.96
140_Q 144_Q 1.093 0.96
121_A 152_A 1.09 0.96
114_S 152_A 1.086 0.96
130_P 134_T 1.085 0.96
124_T 128_Y 1.079 0.95
281_N 284_H 1.076 0.95
261_F 276_R 1.071 0.95
167_R 171_A 1.065 0.95
84_S 90_Q 1.065 0.95
85_D 284_H 1.063 0.95
104_Y 170_L 1.056 0.95
165_S 169_N 1.052 0.95
214_D 276_R 1.052 0.95
82_E 185_K 1.05 0.94
222_F 273_I 1.049 0.94
185_K 204_T 1.045 0.94
312_V 346_W 1.041 0.94
143_D 146_I 1.034 0.94
267_D 270_T 1.03 0.94
163_V 167_R 1.03 0.94
69_P 175_V 1.027 0.94
119_A 123_L 1.026 0.94
194_V 202_L 1.022 0.93
118_A 156_V 1.017 0.93
76_L 97_P 1.016 0.93
66_E 204_T 1.015 0.93
124_T 140_Q 1.011 0.93
80_F 203_A 1.009 0.93
40_T 361_S 1.008 0.93
124_T 144_Q 1.007 0.93
107_A 159_A 1.003 0.93
247_M 292_V 1.003 0.93
213_V 245_L 1.003 0.93
309_Q 341_A 1.002 0.92
58_R 271_G 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vf7A130.90911000.312Contact Map0.839
3lnnA20.88831000.339Contact Map0.763
4l8jA10.81821000.357Contact Map0.633
4dk0A10.84681000.361Contact Map0.632
3fppA20.8391000.361Contact Map0.781
3ne5B20.89871000.388Contact Map0.769
4kkuA40.73771000.4Contact Map0.799
2f1mA40.69351000.469Contact Map0.753
2k32A10.298799.90.739Contact Map0.614
2dneA10.264999.60.799Contact Map0.631

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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