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ACCC - Biotin carboxylase
UniProt: P24182 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10276
Length: 449 (443)
Sequences: 8631
Seq/Len: 19.48

ACCC
Paralog alert: 0.87 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: ACCC DDLA DDLB GSHB PUR2 PURK PURT RIMK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
150_K 175_D 4.24 1.00
93_E 111_R 3.873 1.00
174_G 177_E 3.474 1.00
68_S 72_I 3.375 1.00
4_K 27_K 3.172 1.00
254_R 258_E 3.169 1.00
141_D 144_K 3.026 1.00
146_R 179_A 2.913 1.00
394_N 397_V 2.787 1.00
392_G 397_V 2.779 1.00
5_I 103_I 2.742 1.00
173_R 177_E 2.625 1.00
125_K 266_D 2.604 1.00
62_N 65_A 2.6 1.00
93_E 97_R 2.55 1.00
71_E 98_S 2.52 1.00
258_E 262_K 2.502 1.00
34_S 50_C 2.495 1.00
250_P 254_R 2.491 1.00
132_P 202_K 2.476 1.00
280_E 283_E 2.423 1.00
173_R 205_E 2.412 1.00
3_D 76_V 2.4 1.00
154_Y 175_D 2.38 1.00
123_M 263_A 2.351 1.00
94_Q 98_S 2.307 1.00
4_K 29_V 2.285 1.00
393_E 397_V 2.178 1.00
179_A 183_S 2.104 1.00
121_A 125_K 2.098 1.00
190_K 196_D 2.086 1.00
249_T 252_L 2.061 1.00
218_G 270_R 2.052 1.00
436_N 442_K 2.028 1.00
27_K 47_E 2.006 1.00
337_C 402_M 1.995 1.00
186_R 196_D 1.968 1.00
255_Y 283_E 1.961 1.00
314_R 319_Q 1.915 1.00
86_S 114_G 1.905 1.00
96_E 107_A 1.894 1.00
293_I 308_L 1.892 1.00
261_A 265_V 1.881 1.00
4_K 47_E 1.879 1.00
212_I 256_I 1.856 1.00
147_A 151_R 1.852 1.00
429_N 434_G 1.849 1.00
49_V 69_A 1.832 1.00
67_I 98_S 1.817 1.00
343_D 415_K 1.815 1.00
118_S 121_A 1.794 1.00
311_E 322_S 1.789 1.00
2_L 76_V 1.788 1.00
2_L 317_A 1.776 1.00
49_V 73_T 1.772 1.00
23_E 310_K 1.765 1.00
2_L 101_I 1.765 1.00
67_I 71_E 1.744 1.00
5_I 21_C 1.744 1.00
106_K 270_R 1.723 1.00
7_I 18_L 1.717 1.00
427_D 439_Y 1.714 1.00
262_K 265_V 1.697 1.00
95_V 100_F 1.686 1.00
259_R 284_F 1.683 1.00
31_V 51_I 1.679 1.00
310_K 314_R 1.678 1.00
222_A 261_A 1.674 1.00
140_D 144_K 1.67 1.00
147_A 150_K 1.668 1.00
205_E 281_N 1.654 1.00
175_D 179_A 1.652 1.00
63_I 94_Q 1.64 1.00
171_V 203_Y 1.626 1.00
340_N 383_S 1.624 1.00
113_M 289_M 1.615 1.00
146_R 175_D 1.614 1.00
111_R 118_S 1.58 1.00
134_S 151_R 1.579 1.00
215_L 315_I 1.579 1.00
5_I 26_I 1.577 1.00
70_A 78_I 1.571 1.00
93_E 108_E 1.565 1.00
21_C 28_T 1.558 1.00
106_K 109_T 1.552 1.00
161_S 197_M 1.551 1.00
78_I 100_F 1.55 1.00
22_K 46_D 1.546 1.00
365_V 390_C 1.545 1.00
142_M 179_A 1.54 1.00
143_D 147_A 1.537 1.00
144_K 147_A 1.533 1.00
202_K 285_Y 1.533 1.00
252_L 255_Y 1.531 1.00
30_A 41_H 1.53 1.00
409_L 418_V 1.529 1.00
148_I 151_R 1.526 1.00
215_L 311_E 1.523 1.00
428_E 432_H 1.518 1.00
403_K 426_N 1.501 1.00
353_K 376_T 1.496 1.00
78_I 95_V 1.482 1.00
95_V 102_F 1.477 1.00
121_A 124_K 1.477 1.00
424_I 430_F 1.475 1.00
216_A 222_A 1.472 1.00
64_P 94_Q 1.464 1.00
336_E 387_K 1.457 1.00
407_Q 422_I 1.443 1.00
117_V 121_A 1.435 1.00
149_A 154_Y 1.434 1.00
68_S 71_E 1.434 1.00
255_Y 259_R 1.429 1.00
427_D 443_K 1.424 1.00
112_L 122_A 1.417 1.00
148_I 152_I 1.415 1.00
154_Y 174_G 1.415 1.00
5_I 313_L 1.41 1.00
142_M 146_R 1.409 1.00
255_Y 258_E 1.406 0.99
120_I 201_E 1.405 0.99
182_I 198_V 1.402 0.99
354_I 371_I 1.4 0.99
305_G 329_H 1.379 0.99
146_R 150_K 1.379 0.99
94_Q 97_R 1.375 0.99
108_E 112_L 1.362 0.99
122_A 126_A 1.353 0.99
96_E 270_R 1.349 0.99
67_I 94_Q 1.342 0.99
420_L 424_I 1.339 0.99
55_P 58_K 1.336 0.99
420_L 440_L 1.336 0.99
65_A 68_S 1.334 0.99
396_D 400_A 1.332 0.99
214_V 264_C 1.327 0.99
69_A 73_T 1.324 0.99
353_K 375_Y 1.319 0.99
329_H 332_G 1.316 0.99
220_G 265_V 1.314 0.99
223_I 323_I 1.304 0.99
158_I 198_V 1.297 0.99
2_L 77_A 1.296 0.99
30_A 45_A 1.294 0.99
20_A 310_K 1.289 0.99
392_G 401_R 1.282 0.99
262_K 266_D 1.279 0.99
438_H 441_E 1.267 0.99
403_K 431_Q 1.26 0.99
18_L 44_L 1.25 0.99
70_A 100_F 1.243 0.98
128_V 286_F 1.237 0.98
404_N 408_E 1.235 0.98
143_D 146_R 1.234 0.98
103_I 313_L 1.232 0.98
243_A 303_I 1.23 0.98
142_M 182_I 1.229 0.98
400_A 431_Q 1.22 0.98
15_L 44_L 1.206 0.98
217_D 221_N 1.198 0.98
252_L 279_F 1.194 0.98
26_I 317_A 1.181 0.98
119_A 123_M 1.179 0.98
144_K 148_I 1.177 0.98
101_I 317_A 1.174 0.98
142_M 183_S 1.17 0.97
215_L 272_A 1.169 0.97
335_V 398_A 1.168 0.97
149_A 178_L 1.166 0.97
251_E 255_Y 1.163 0.97
172_V 181_S 1.161 0.97
137_P 197_M 1.16 0.97
170_R 188_E 1.158 0.97
124_K 130_C 1.157 0.97
223_I 328_V 1.155 0.97
145_N 178_L 1.152 0.97
93_E 107_A 1.152 0.97
154_Y 178_L 1.151 0.97
226_A 328_V 1.144 0.97
149_A 156_V 1.142 0.97
305_G 327_E 1.136 0.97
112_L 118_S 1.136 0.97
212_I 257_G 1.132 0.97
149_A 182_I 1.132 0.97
63_I 67_I 1.132 0.97
138_L 148_I 1.124 0.97
335_V 399_I 1.121 0.97
438_H 442_K 1.107 0.96
219_Q 265_V 1.106 0.96
248_I 252_L 1.105 0.96
27_K 46_D 1.103 0.96
157_I 203_Y 1.1 0.96
372_Y 375_Y 1.099 0.96
251_E 254_R 1.098 0.96
122_A 125_K 1.096 0.96
429_N 443_K 1.09 0.96
402_M 425_M 1.089 0.96
206_N 436_N 1.08 0.95
92_A 102_F 1.077 0.95
145_N 182_I 1.071 0.95
219_Q 320_P 1.071 0.95
254_R 257_G 1.068 0.95
388_L 409_L 1.065 0.95
96_E 106_K 1.064 0.95
67_I 97_R 1.06 0.95
302_M 391_Y 1.053 0.95
123_M 286_F 1.046 0.94
399_I 425_M 1.046 0.94
106_K 268_G 1.045 0.94
157_I 171_V 1.043 0.94
324_K 327_E 1.037 0.94
32_H 48_T 1.036 0.94
124_K 135_D 1.033 0.94
91_F 95_V 1.03 0.94
70_A 95_V 1.028 0.94
152_I 156_V 1.023 0.93
64_P 68_S 1.022 0.93
256_I 284_F 1.02 0.93
140_D 197_M 1.019 0.93
397_V 401_R 1.01 0.93
108_E 111_R 1.009 0.93
224_Y 257_G 1.009 0.93
204_L 287_I 1.007 0.93
212_I 260_C 1.007 0.93
156_V 200_M 1.005 0.93
301_E 389_I 1.002 0.92
260_C 289_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3n6rA60.96211000.27Contact Map0.685
3va7A10.8331000.281Contact Map0.72
3u9tA10.96661000.282Contact Map0.678
3hblA40.99331000.287Contact Map0.799
2qf7A20.89531000.287Contact Map0.729
1w96A30.97331000.289Contact Map0.711
1ulzA10.99111000.296Contact Map0.778
2dzdA20.99781000.304Contact Map0.786
3jrxA10.92871000.309Contact Map0.714
2w70A20.98891000.31Contact Map0.756

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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