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ACPS - Holo-[acyl-carrier-protein] synthase
UniProt: P24224 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10247
Length: 126 (125)
Sequences: 1520
Seq/Len: 12.16

ACPS
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
52_K 111_L 3.329 1.00
108_H 125_E 2.721 1.00
52_K 113_D 2.538 1.00
96_L 100_E 2.536 1.00
60_A 89_L 2.471 1.00
56_V 109_V 2.444 1.00
33_S 78_E 2.412 1.00
8_T 119_C 2.206 1.00
60_A 122_V 2.202 1.00
8_T 121_T 2.197 1.00
35_N 78_E 2.192 1.00
6_L 121_T 2.191 1.00
89_L 122_V 2.181 1.00
112_A 119_C 2.176 1.00
17_E 21_A 2.048 1.00
28_A 37_W 1.973 1.00
56_V 79_V 1.909 1.00
82_D 86_K 1.905 1.00
80_F 88_R 1.845 1.00
12_E 116_H 1.843 1.00
53_R 81_N 1.842 1.00
12_E 114_E 1.811 1.00
55_A 120_A 1.806 1.00
10_I 117_Y 1.73 1.00
61_A 68_I 1.664 1.00
8_T 110_T 1.656 1.00
99_A 104_V 1.608 1.00
10_I 119_C 1.503 1.00
40_W 50_L 1.462 1.00
19_V 23_S 1.429 1.00
98_L 102_L 1.406 0.99
5_G 108_H 1.395 0.99
29_R 34_D 1.37 0.99
48_R 113_D 1.355 0.99
106_N 125_E 1.355 0.99
3_I 108_H 1.349 0.99
13_I 118_A 1.332 0.99
29_R 37_W 1.33 0.99
14_A 116_H 1.328 0.99
37_W 50_L 1.265 0.99
11_V 55_A 1.264 0.99
68_I 74_F 1.262 0.99
27_L 31_V 1.256 0.99
60_A 64_F 1.249 0.99
94_E 97_K 1.248 0.99
91_L 107_M 1.242 0.98
32_L 40_W 1.242 0.98
25_D 29_R 1.232 0.98
13_I 47_V 1.229 0.98
37_W 41_K 1.21 0.98
32_L 50_L 1.204 0.98
80_F 90_R 1.198 0.98
41_K 50_L 1.188 0.98
40_W 49_F 1.185 0.98
107_M 124_I 1.159 0.97
11_V 16_I 1.14 0.97
77_F 89_L 1.118 0.96
32_L 49_F 1.115 0.96
60_A 77_F 1.113 0.96
11_V 118_A 1.107 0.96
39_I 81_N 1.104 0.96
8_T 112_A 1.095 0.96
82_D 88_R 1.086 0.96
5_G 125_E 1.059 0.95
61_A 72_L 1.047 0.94
78_E 92_W 1.04 0.94
98_L 101_K 1.038 0.94
55_A 118_A 1.037 0.94
97_K 100_E 1.014 0.93
114_E 117_Y 1.01 0.93
13_I 51_A 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2uv9A60.96831000.089Contact Map
2uv8A30.96831000.092Contact Map
2bddA10.99211000.149Contact Map0.672
2qg8A10.99211000.161Contact Map0.675
3h88A2411000.193Contact Map0.901
3nfdA60.96831000.193Contact Map0.742
2wdsA10.97621000.194Contact Map0.62
3gwmA10.96031000.233Contact Map0.599
3hykA30.91271000.284Contact Map0.865
3f09A30.90481000.29Contact Map0.849

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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