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CODA - Cytosine deaminase
UniProt: P25524 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11326
Length: 427 (405)
Sequences: 11246
Seq/Len: 27.77

CODA
Paralog alert: 0.83 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
399_V 404_V 4.974 1.00
9_I 49_A 4.804 1.00
397_Y 404_V 3.966 1.00
26_Q 31_S 3.913 1.00
49_A 379_I 3.904 1.00
52_G 396_R 3.895 1.00
57_P 118_Q 3.691 1.00
370_A 373_N 3.559 1.00
12_A 49_A 3.556 1.00
32_A 371_A 3.514 1.00
23_I 54_V 3.399 1.00
346_Q 349_D 3.34 1.00
55_I 380_L 3.185 1.00
264_R 305_S 2.992 1.00
10_I 46_S 2.962 1.00
374_S 401_G 2.961 1.00
300_K 304_E 2.889 1.00
369_I 377_L 2.819 1.00
54_V 379_I 2.765 1.00
235_H 269_S 2.759 1.00
25_L 377_L 2.756 1.00
8_T 24_H 2.685 1.00
45_N 407_S 2.613 1.00
28_G 374_S 2.599 1.00
349_D 352_N 2.592 1.00
12_A 54_V 2.527 1.00
204_L 207_K 2.514 1.00
55_I 378_I 2.483 1.00
364_L 367_Y 2.47 1.00
308_N 360_R 2.416 1.00
11_N 48_D 2.405 1.00
52_G 381_P 2.396 1.00
377_L 399_V 2.393 1.00
29_K 374_S 2.391 1.00
54_V 377_L 2.307 1.00
7_Q 399_V 2.296 1.00
10_I 22_Q 2.262 1.00
23_I 369_I 2.248 1.00
381_P 396_R 2.173 1.00
398_S 406_A 2.163 1.00
352_N 356_H 2.16 1.00
114_A 406_A 2.133 1.00
357_H 360_R 2.096 1.00
9_I 25_L 2.062 1.00
33_I 371_A 2.061 1.00
367_Y 374_S 2.051 1.00
52_G 379_I 2.019 1.00
34_D 37_S 1.997 1.00
263_F 305_S 1.994 1.00
28_G 401_G 1.977 1.00
113_I 405_I 1.899 1.00
24_H 32_A 1.835 1.00
378_I 395_V 1.823 1.00
7_Q 25_L 1.758 1.00
264_R 268_M 1.755 1.00
205_A 212_I 1.748 1.00
272_N 361_T 1.748 1.00
49_A 54_V 1.73 1.00
97_T 100_D 1.725 1.00
298_R 301_E 1.718 1.00
14_L 23_I 1.714 1.00
303_L 349_D 1.709 1.00
379_I 399_V 1.706 1.00
23_I 377_L 1.69 1.00
59_V 358_S 1.673 1.00
253_S 301_E 1.67 1.00
356_H 373_N 1.668 1.00
310_C 361_T 1.662 1.00
265_L 269_S 1.656 1.00
8_T 22_Q 1.656 1.00
14_L 21_W 1.655 1.00
302_M 307_I 1.64 1.00
55_I 58_F 1.611 1.00
61_P 274_V 1.611 1.00
265_L 268_M 1.599 1.00
61_P 310_C 1.592 1.00
404_V 407_S 1.582 1.00
102_K 106_W 1.575 1.00
248_T 273_F 1.57 1.00
47_L 399_V 1.562 1.00
59_V 359_A 1.559 1.00
397_Y 407_S 1.544 1.00
200_K 203_A 1.538 1.00
135_K 139_E 1.521 1.00
199_H 203_A 1.507 1.00
203_A 207_K 1.507 1.00
9_I 377_L 1.506 1.00
400_R 405_I 1.496 1.00
352_N 357_H 1.491 1.00
53_L 382_A 1.437 1.00
195_V 199_H 1.431 1.00
301_E 305_S 1.423 1.00
232_A 236_H 1.421 1.00
209_D 242_R 1.421 1.00
112_Q 120_V 1.418 1.00
25_L 399_V 1.416 1.00
12_A 379_I 1.411 1.00
9_I 399_V 1.405 0.99
61_P 358_S 1.399 0.99
102_K 139_E 1.397 0.99
31_S 371_A 1.392 0.99
136_A 139_E 1.387 0.99
24_H 31_S 1.387 0.99
267_K 307_I 1.382 0.99
386_F 394_P 1.379 0.99
174_L 210_R 1.379 0.99
55_I 351_L 1.379 0.99
139_E 143_E 1.377 0.99
301_E 304_E 1.362 0.99
310_C 357_H 1.354 0.99
359_A 368_G 1.352 0.99
360_R 365_Q 1.35 0.99
7_Q 45_N 1.348 0.99
356_H 360_R 1.346 0.99
121_R 362_L 1.346 0.99
139_E 142_Q 1.344 0.99
378_I 398_S 1.329 0.99
380_L 395_V 1.327 0.99
274_V 310_C 1.327 0.99
267_K 309_V 1.311 0.99
21_W 33_I 1.306 0.99
365_Q 373_N 1.305 0.99
22_Q 37_S 1.302 0.99
351_L 355_T 1.301 0.99
395_V 398_S 1.299 0.99
6_L 24_H 1.298 0.99
11_N 50_E 1.292 0.99
24_H 44_E 1.285 0.99
113_I 400_R 1.284 0.99
113_I 148_I 1.267 0.99
59_V 119_H 1.261 0.99
171_E 208_Y 1.258 0.99
47_L 397_Y 1.255 0.99
224_S 228_E 1.248 0.99
379_I 397_Y 1.242 0.98
272_N 308_N 1.242 0.98
6_L 26_Q 1.227 0.98
396_R 408_T 1.224 0.98
251_M 302_M 1.221 0.98
332_L 350_G 1.215 0.98
61_P 362_L 1.213 0.98
21_W 35_A 1.212 0.98
13_R 18_E 1.212 0.98
13_R 20_L 1.207 0.98
366_D 373_N 1.203 0.98
381_P 384_N 1.2 0.98
204_L 208_Y 1.196 0.98
30_I 377_L 1.181 0.98
12_A 377_L 1.177 0.98
376_N 400_R 1.173 0.98
113_I 398_S 1.168 0.97
172_E 176_L 1.158 0.97
140_V 143_E 1.157 0.97
267_K 305_S 1.153 0.97
211_L 363_N 1.149 0.97
30_I 369_I 1.147 0.97
65_L 108_T 1.143 0.97
137_M 141_K 1.141 0.97
205_A 210_R 1.13 0.97
7_Q 47_L 1.129 0.97
45_N 404_V 1.127 0.97
23_I 33_I 1.125 0.97
60_E 63_I 1.121 0.97
336_L 350_G 1.121 0.97
225_R 228_E 1.12 0.96
194_G 197_S 1.118 0.96
199_H 233_L 1.117 0.96
310_C 358_S 1.116 0.96
11_N 20_L 1.115 0.96
10_I 48_D 1.114 0.96
199_H 236_H 1.103 0.96
65_L 120_V 1.089 0.96
59_V 367_Y 1.084 0.96
113_I 406_A 1.083 0.96
263_F 302_M 1.08 0.95
35_A 38_G 1.074 0.95
64_H 314_D 1.071 0.95
266_L 273_F 1.064 0.95
245_A 248_T 1.06 0.95
213_D 246_S 1.059 0.95
175_R 208_Y 1.057 0.95
196_E 199_H 1.05 0.94
167_E 171_E 1.042 0.94
206_Q 243_V 1.04 0.94
11_N 49_A 1.035 0.94
118_Q 398_S 1.034 0.94
198_L 214_V 1.034 0.94
308_N 357_H 1.033 0.94
11_N 51_Q 1.032 0.94
263_F 301_E 1.03 0.94
171_E 204_L 1.023 0.93
9_I 54_V 1.019 0.93
171_E 207_K 1.017 0.93
235_H 265_L 1.015 0.93
169_L 172_E 1.013 0.93
119_H 367_Y 1.013 0.93
385_G 392_Q 1.013 0.93
244_T 361_T 1.013 0.93
171_E 175_R 1.005 0.93
13_R 53_L 1.004 0.93
24_H 34_D 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ra0A10.99771000.212Contact Map0.774
4dzhA10.92741000.317Contact Map0.779
2qt3A20.91331000.319Contact Map0.827
4gbdA20.92741000.335Contact Map0.798
4f0rA10.92741000.339Contact Map0.809
3lnpA10.92741000.346Contact Map0.795
3ls9A20.92271000.351Contact Map0.79
2pajA10.93441000.356Contact Map0.75
3h4uA20.94151000.362Contact Map0.775
4aqlA10.8971000.363Contact Map0.731

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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