GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
ASLB - Anaerobic sulfatase-maturating enzyme homolog AslB
UniProt: P25550 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10090
Length: 411 (376)
Sequences: 2091
Seq/Len: 5.56

ASLB
Paralog alert: 0.56 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ASLB MOAA YDEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
134_P 151_K 6.927 1.00
49_T 311_H 4.281 1.00
138_N 148_P 3.763 1.00
293_D 309_N 3.376 1.00
150_H 187_F 3.366 1.00
117_A 163_H 3.362 1.00
297_C 352_C 3.24 1.00
46_D 49_T 3.139 1.00
23_L 109_V 2.965 1.00
113_D 159_L 2.878 1.00
22_N 107_N 2.749 1.00
282_C 297_C 2.744 1.00
51_E 90_L 2.698 1.00
186_D 190_D 2.617 1.00
293_D 306_R 2.614 1.00
47_D 86_R 2.54 1.00
52_A 56_H 2.535 1.00
55_R 90_L 2.525 1.00
113_D 162_K 2.52 1.00
111_L 116_C 2.489 1.00
134_P 138_N 2.434 1.00
158_T 191_A 2.304 1.00
158_T 162_K 2.225 1.00
282_C 352_C 2.209 1.00
117_A 121_E 2.166 1.00
50_L 87_A 2.055 1.00
309_N 312_Q 2.05 1.00
180_Q 183_Q 2.045 1.00
92_A 122_H 2.033 1.00
133_P 136_I 2.013 1.00
116_C 159_L 1.999 1.00
133_P 180_Q 1.991 1.00
152_L 155_R 1.959 1.00
313_Q 317_E 1.952 1.00
314_T 317_E 1.948 1.00
131_D 141_R 1.941 1.00
154_M 191_A 1.925 1.00
45_M 49_T 1.925 1.00
112_D 115_W 1.889 1.00
108_G 128_L 1.885 1.00
24_N 144_K 1.875 1.00
105_Q 127_G 1.831 1.00
128_L 157_L 1.813 1.00
126_V 160_L 1.812 1.00
143_T 147_R 1.779 1.00
113_D 163_H 1.747 1.00
23_L 149_T 1.728 1.00
55_R 98_R 1.725 1.00
128_L 156_A 1.717 1.00
137_H 149_T 1.707 1.00
79_L 82_A 1.697 1.00
175_R 236_E 1.684 1.00
289_E 293_D 1.681 1.00
137_H 148_P 1.676 1.00
336_P 362_S 1.661 1.00
54_V 69_F 1.658 1.00
169_V 193_V 1.635 0.99
186_D 247_H 1.605 0.99
157_L 167_Y 1.588 0.99
22_N 110_L 1.579 0.99
118_F 122_H 1.57 0.99
151_K 155_R 1.568 0.99
130_L 169_V 1.568 0.99
111_L 119_L 1.567 0.99
182_L 243_A 1.546 0.99
85_R 121_E 1.545 0.99
22_N 75_E 1.523 0.99
169_V 188_L 1.518 0.99
143_T 152_L 1.504 0.99
71_W 102_N 1.503 0.99
91_Q 102_N 1.496 0.99
158_T 161_Q 1.476 0.99
136_I 180_Q 1.476 0.99
294_V 318_M 1.461 0.99
139_Q 176_T 1.452 0.98
21_C 28_C 1.446 0.98
153_V 156_A 1.444 0.98
109_V 156_A 1.422 0.98
242_V 246_D 1.42 0.98
88_V 118_F 1.418 0.98
155_R 159_L 1.417 0.98
25_C 28_C 1.414 0.98
90_L 93_K 1.408 0.98
187_F 191_A 1.407 0.98
159_L 162_K 1.399 0.98
51_E 85_R 1.397 0.98
26_D 142_V 1.384 0.98
69_F 91_Q 1.379 0.98
29_F 72_Q 1.376 0.98
183_Q 186_D 1.369 0.97
132_G 150_H 1.368 0.97
179_Q 239_E 1.364 0.97
12_V 57_Y 1.356 0.97
20_D 44_H 1.353 0.97
15_K 170_L 1.35 0.97
82_A 86_R 1.349 0.97
51_E 86_R 1.339 0.97
295_Y 306_R 1.338 0.97
21_C 25_C 1.327 0.97
75_E 106_T 1.305 0.96
160_L 165_V 1.27 0.96
134_P 150_H 1.27 0.96
155_R 158_T 1.268 0.96
104_F 126_V 1.268 0.96
120_A 164_H 1.265 0.95
89_A 93_K 1.261 0.95
170_L 199_I 1.256 0.95
132_G 141_R 1.255 0.95
84_Y 115_W 1.254 0.95
317_E 320_D 1.249 0.95
88_V 122_H 1.247 0.95
77_T 110_L 1.245 0.95
305_Y 357_F 1.244 0.95
26_D 139_Q 1.24 0.95
54_V 98_R 1.233 0.95
129_S 172_C 1.224 0.94
156_A 159_L 1.22 0.94
172_C 201_V 1.212 0.94
116_C 156_A 1.212 0.94
138_N 149_T 1.207 0.94
170_L 298_D 1.193 0.93
88_V 124_F 1.188 0.93
49_T 52_A 1.186 0.93
120_A 163_H 1.185 0.93
339_C 342_C 1.174 0.93
154_M 187_F 1.172 0.92
342_C 348_C 1.166 0.92
71_W 87_A 1.161 0.92
171_V 196_I 1.159 0.92
19_S 290_H 1.156 0.92
294_V 315_I 1.149 0.91
23_L 143_T 1.141 0.91
117_A 120_A 1.133 0.91
89_A 118_F 1.131 0.91
185_Y 189_C 1.128 0.90
116_C 165_V 1.126 0.90
53_Y 310_M 1.113 0.90
140_Y 174_N 1.112 0.90
116_C 163_H 1.108 0.89
360_D 366_G 1.108 0.89
107_N 110_L 1.104 0.89
51_E 93_K 1.102 0.89
128_L 160_L 1.093 0.89
55_R 59_A 1.093 0.89
57_Y 69_F 1.09 0.88
47_D 51_E 1.089 0.88
186_D 189_C 1.086 0.88
52_A 55_R 1.083 0.88
52_A 311_H 1.082 0.88
108_G 157_L 1.073 0.87
152_L 156_A 1.073 0.87
344_V 379_R 1.069 0.87
118_F 121_E 1.069 0.87
75_E 107_N 1.062 0.87
342_C 371_C 1.06 0.86
324_Q 328_G 1.059 0.86
375_Q 378_F 1.058 0.86
343_N 379_R 1.047 0.85
291_N 309_N 1.041 0.85
133_P 183_Q 1.037 0.85
114_E 117_A 1.036 0.85
322_P 325_Q 1.033 0.84
348_C 371_C 1.03 0.84
339_C 348_C 1.028 0.84
233_R 236_E 1.028 0.84
72_Q 105_Q 1.025 0.84
157_L 193_V 1.025 0.84
132_G 136_I 1.021 0.83
116_C 120_A 1.021 0.83
51_E 55_R 1.021 0.83
110_L 156_A 1.019 0.83
85_R 114_E 1.019 0.83
307_L 324_Q 1.009 0.82
81_L 118_F 1.008 0.82
45_M 50_L 1.007 0.82
154_M 158_T 1.005 0.82
159_L 163_H 1.003 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4k36A20.93431000.317Contact Map0.737
1tv8A20.77371000.616Contact Map0.638
4m7tA10.59611000.623Contact Map0.565
3c8fA10.54741000.698Contact Map0.541
2yx0A10.608399.90.736Contact Map0.548
3rfaA20.661899.90.743Contact Map0.491
2z2uA10.593799.90.744Contact Map0.623
2qgqA80.67499.90.745Contact Map0.611
2a5hA40.678899.90.758Contact Map0.51
4jc0A20.69199.90.761Contact Map0.526

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0351 seconds.