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ALDA - Lactaldehyde dehydrogenase
UniProt: P25553 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10035
Length: 479 (471)
Sequences: 17778
Seq/Len: 37.75

ALDA
Paralog alert: 0.85 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
295_K 395_D 5.363 1.00
239_A 243_K 3.676 1.00
295_K 393_A 3.174 1.00
267_E 304_R 3.104 1.00
262_D 294_Q 2.86 1.00
331_A 335_E 2.766 1.00
374_R 377_M 2.745 1.00
25_D 37_R 2.738 1.00
80_R 113_D 2.737 1.00
54_E 221_K 2.73 1.00
298_Y 393_A 2.71 1.00
356_K 366_P 2.695 1.00
342_A 346_E 2.651 1.00
262_D 296_G 2.576 1.00
343_R 378_S 2.572 1.00
271_K 308_A 2.558 1.00
82_R 85_E 2.498 1.00
302_V 391_V 2.487 1.00
187_A 190_K 2.481 1.00
417_T 423_A 2.389 1.00
328_L 337_V 2.367 1.00
12_D 55_R 2.363 1.00
193_D 199_R 2.353 1.00
341_V 365_Y 2.353 1.00
54_E 223_A 2.256 1.00
306_G 310_Q 2.154 1.00
425_K 429_G 2.139 1.00
25_D 34_V 2.133 1.00
42_Q 45_D 2.122 1.00
350_R 372_D 2.032 1.00
397_L 425_K 2.031 1.00
338_E 342_A 2.031 1.00
83_A 106_A 2.013 1.00
397_L 422_V 1.994 1.00
78_G 194_E 1.967 1.00
370_L 379_I 1.956 1.00
75_I 192_V 1.948 1.00
9_M 41_G 1.928 1.00
292_Y 400_A 1.912 1.00
345_V 351_V 1.902 1.00
51_D 221_K 1.9 1.00
303_N 307_E 1.896 1.00
300_Q 304_R 1.892 1.00
71_W 197_L 1.889 1.00
84_S 102_E 1.882 1.00
180_F 330_N 1.88 1.00
343_R 347_E 1.877 1.00
291_V 389_L 1.841 1.00
258_A 273_I 1.838 1.00
10_Y 193_D 1.831 1.00
338_E 357_A 1.82 1.00
112_I 164_A 1.817 1.00
352_A 371_L 1.814 1.00
408_D 454_K 1.814 1.00
77_A 81_E 1.802 1.00
78_G 81_E 1.799 1.00
141_R 473_Q 1.778 1.00
214_Q 218_G 1.773 1.00
140_K 470_L 1.772 1.00
263_D 422_V 1.766 1.00
378_S 382_E 1.761 1.00
338_E 365_Y 1.748 1.00
218_G 240_T 1.747 1.00
395_D 399_D 1.74 1.00
47_R 215_E 1.73 1.00
350_R 371_L 1.722 1.00
47_R 51_D 1.718 1.00
399_D 402_S 1.708 1.00
85_E 187_A 1.705 1.00
78_G 191_I 1.692 1.00
235_E 454_K 1.691 1.00
309_M 369_L 1.69 1.00
57_Q 61_E 1.669 1.00
351_V 370_L 1.668 1.00
77_A 113_D 1.645 1.00
292_Y 403_M 1.637 1.00
299_D 393_A 1.637 1.00
262_D 422_V 1.634 1.00
306_G 352_A 1.632 1.00
431_K 453_R 1.63 1.00
298_Y 302_V 1.614 1.00
84_S 88_A 1.601 1.00
398_E 429_G 1.595 1.00
375_Q 403_M 1.594 1.00
413_S 432_F 1.59 1.00
236_K 239_A 1.584 1.00
73_R 113_D 1.575 1.00
294_Q 394_F 1.567 1.00
189_A 204_L 1.56 1.00
78_G 195_I 1.558 1.00
172_T 201_V 1.549 1.00
300_Q 303_N 1.545 1.00
272_A 416_Y 1.545 1.00
140_K 467_H 1.544 1.00
14_Q 199_R 1.543 1.00
308_A 311_A 1.536 1.00
74_K 77_A 1.525 1.00
380_M 392_V 1.52 1.00
80_R 109_A 1.512 1.00
64_P 67_E 1.505 1.00
8_P 17_T 1.501 1.00
294_Q 396_T 1.498 1.00
349_A 370_L 1.496 1.00
82_R 194_E 1.485 1.00
273_I 301_F 1.484 1.00
89_L 187_A 1.464 1.00
266_L 304_R 1.458 1.00
47_R 219_N 1.445 1.00
313_Q 321_N 1.444 1.00
401_I 426_A 1.443 1.00
335_E 339_Q 1.437 1.00
304_R 307_E 1.432 1.00
396_T 399_D 1.429 1.00
342_A 345_V 1.426 1.00
261_M 422_V 1.418 1.00
67_E 70_S 1.418 1.00
339_Q 378_S 1.411 1.00
293_V 301_F 1.408 1.00
62_A 429_G 1.405 0.99
34_V 37_R 1.398 0.99
27_V 34_V 1.381 0.99
57_Q 172_T 1.379 0.99
88_A 92_E 1.378 0.99
307_E 311_A 1.367 0.99
331_A 363_Y 1.366 0.99
16_V 48_K 1.356 0.99
298_Y 371_L 1.337 0.99
270_V 304_R 1.334 0.99
273_I 291_V 1.328 0.99
50_I 219_N 1.327 0.99
278_V 309_M 1.326 0.99
148_G 173_I 1.325 0.99
334_L 338_E 1.322 0.99
261_M 394_F 1.319 0.99
347_E 378_S 1.318 0.99
139_F 428_K 1.315 0.99
399_D 403_M 1.312 0.99
28_N 31_T 1.311 0.99
76_S 113_D 1.311 0.99
118_W 121_R 1.304 0.99
307_E 310_Q 1.296 0.99
46_A 212_V 1.287 0.99
33_A 361_K 1.284 0.99
340_K 384_T 1.284 0.99
88_A 318_A 1.281 0.99
86_I 187_A 1.278 0.99
190_K 194_E 1.276 0.99
334_L 365_Y 1.269 0.99
51_D 55_R 1.266 0.99
310_Q 353_F 1.264 0.99
112_I 160_A 1.254 0.99
312_V 325_M 1.251 0.99
238_M 457_I 1.251 0.99
344_A 370_L 1.245 0.98
192_V 202_F 1.236 0.98
258_A 288_A 1.234 0.98
63_L 67_E 1.232 0.98
91_V 101_A 1.229 0.98
331_A 334_L 1.222 0.98
224_M 249_C 1.216 0.98
316_N 319_E 1.216 0.98
98_Q 102_E 1.212 0.98
292_Y 394_F 1.21 0.98
74_K 78_G 1.21 0.98
398_E 425_K 1.208 0.98
261_M 426_A 1.207 0.98
45_D 48_K 1.205 0.98
75_I 112_I 1.19 0.98
394_F 403_M 1.188 0.98
76_S 80_R 1.185 0.98
75_I 191_I 1.183 0.98
259_I 400_A 1.182 0.98
159_I 175_I 1.181 0.98
82_R 187_A 1.173 0.98
381_H 406_D 1.172 0.98
148_G 226_S 1.171 0.98
464_H 467_H 1.159 0.97
83_A 102_E 1.157 0.97
36_S 183_N 1.157 0.97
401_I 405_N 1.153 0.97
86_I 191_I 1.144 0.97
401_I 429_G 1.143 0.97
381_H 408_D 1.141 0.97
23_W 37_R 1.141 0.97
10_Y 15_F 1.14 0.97
214_Q 240_T 1.138 0.97
139_F 475_V 1.138 0.97
236_K 240_T 1.133 0.97
413_S 435_T 1.133 0.97
189_A 202_F 1.132 0.97
73_R 120_R 1.128 0.97
299_D 303_N 1.128 0.97
427_I 475_V 1.124 0.97
337_V 386_G 1.117 0.96
376_E 381_H 1.111 0.96
334_L 357_A 1.109 0.96
50_I 221_K 1.104 0.96
163_M 202_F 1.101 0.96
125_E 464_H 1.096 0.96
345_V 370_L 1.094 0.96
302_V 306_G 1.091 0.96
28_N 316_N 1.091 0.96
301_F 305_L 1.09 0.96
82_R 191_I 1.087 0.96
91_V 317_P 1.084 0.96
125_E 463_K 1.083 0.96
305_L 389_L 1.082 0.96
233_A 236_K 1.08 0.95
140_K 472_T 1.079 0.95
214_Q 236_K 1.072 0.95
137_L 424_M 1.07 0.95
52_A 200_G 1.068 0.95
32_E 361_K 1.068 0.95
147_T 222_V 1.066 0.95
375_Q 406_D 1.064 0.95
259_I 426_A 1.064 0.95
145_V 222_V 1.063 0.95
75_I 197_L 1.063 0.95
397_L 426_A 1.062 0.95
419_N 422_V 1.061 0.95
261_M 294_Q 1.06 0.95
32_E 363_Y 1.054 0.95
294_Q 297_I 1.051 0.94
58_P 402_S 1.051 0.94
400_A 403_M 1.05 0.94
423_A 437_I 1.048 0.94
218_G 243_K 1.046 0.94
339_Q 343_R 1.044 0.94
215_E 219_N 1.043 0.94
297_I 300_Q 1.042 0.94
310_Q 366_P 1.039 0.94
154_F 284_V 1.039 0.94
302_V 352_A 1.039 0.94
238_M 248_V 1.039 0.94
230_S 233_A 1.037 0.94
463_K 467_H 1.035 0.94
306_G 353_F 1.032 0.94
263_D 419_N 1.024 0.93
315_G 322_D 1.023 0.93
63_L 71_W 1.023 0.93
20_G 42_Q 1.023 0.93
398_E 402_S 1.023 0.93
88_A 98_Q 1.021 0.93
313_Q 324_A 1.015 0.93
143_L 171_N 1.007 0.93
223_A 431_K 1.007 0.93
268_L 418_Q 1.005 0.93
22_A 40_D 1.005 0.93
12_D 52_A 1.005 0.93
299_D 302_V 1.002 0.92
19_R 48_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i8pA20.99791000.006Contact Map0.78
3k2wA80.99791000.009Contact Map0.862
3ek1A80.99371000.012Contact Map0.801
3ed6A20.99791000.013Contact Map0.786
4f3xA40.99371000.013Contact Map0.722
2o2pA40.99791000.014Contact Map0.817
4i9bA20.99791000.015Contact Map0.758
3u4jA40.99791000.015Contact Map0.806
1a4sA40.99371000.016Contact Map0.785
1o04A80.99581000.016Contact Map0.827

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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