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APPC - Cytochrome bd-II oxidase subunit 1
UniProt: P26459 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11380
Length: 514 (492)
Sequences: 1275
Seq/Len: 2.59

APPC
Paralog alert: 0.45 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: APPC CYDA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
170_S 173_E 6.249 1.00
452_A 462_A 5.24 1.00
276_E 283_A 4.945 1.00
201_A 430_L 4.937 1.00
235_L 401_L 4.247 1.00
273_A 282_N 3.593 1.00
128_L 132_L 3.482 1.00
261_Q 308_K 3.387 1.00
297_T 302_K 3.303 1.00
276_E 279_Q 3.125 1.00
294_I 300_L 2.966 1.00
189_M 237_L 2.949 1.00
280_E 308_K 2.937 1.00
44_G 123_K 2.801 1.00
194_T 437_I 2.784 1.00
398_S 402_L 2.672 1.00
239_D 298_H 2.61 1.00
34_A 131_W 2.581 1.00
224_S 407_A 2.575 1.00
239_D 243_Y 2.492 1.00
197_M 227_G 2.476 1.00
469_G 473_F 2.335 1.00
442_F 446_F 2.282 1.00
3_D 6_D 2.216 1.00
410_Q 422_V 2.169 1.00
243_Y 298_H 2.166 1.00
420_R 424_K 2.163 1.00
41_V 127_L 2.148 1.00
121_L 129_V 2.135 1.00
280_E 380_I 2.12 1.00
266_P 290_A 2.08 1.00
396_C 400_L 2.032 1.00
20_F 187_T 1.938 0.99
290_A 300_L 1.936 0.99
270_H 287_K 1.917 0.99
282_N 285_A 1.912 0.99
472_A 476_I 1.878 0.99
251_V 310_L 1.871 0.99
88_V 92_F 1.863 0.99
35_I 39_I 1.862 0.99
399_L 429_S 1.817 0.99
158_H 169_T 1.805 0.99
270_H 387_F 1.771 0.98
38_T 131_W 1.764 0.98
26_T 62_N 1.757 0.98
122_N 125_Q 1.748 0.98
17_L 438_E 1.728 0.98
38_T 127_L 1.717 0.98
172_S 175_V 1.716 0.98
279_Q 283_A 1.715 0.98
403_V 429_S 1.699 0.98
385_P 446_F 1.689 0.98
421_W 424_K 1.684 0.98
231_I 401_L 1.683 0.98
268_P 287_K 1.676 0.97
55_W 219_S 1.674 0.97
424_K 428_W 1.669 0.97
14_L 475_L 1.639 0.97
379_A 458_P 1.634 0.97
14_L 479_V 1.628 0.97
51_M 219_S 1.624 0.97
58_L 493_M 1.606 0.96
4_V 8_S 1.593 0.96
262_T 303_P 1.59 0.96
197_M 403_V 1.581 0.96
270_H 273_A 1.58 0.96
33_L 130_T 1.577 0.96
113_L 121_L 1.57 0.96
157_A 456_I 1.565 0.96
83_F 86_N 1.564 0.96
168_M 174_L 1.524 0.95
382_Q 446_F 1.522 0.95
494_Q 498_R 1.519 0.95
92_F 147_A 1.517 0.95
221_A 411_T 1.516 0.95
8_S 471_L 1.512 0.95
392_I 439_A 1.51 0.95
17_L 442_F 1.505 0.94
25_L 198_F 1.496 0.94
260_W 282_N 1.495 0.94
449_Q 459_T 1.494 0.94
305_P 313_E 1.476 0.94
320_R 347_L 1.454 0.93
277_Q 384_A 1.447 0.93
46_T 50_D 1.438 0.92
58_L 198_F 1.435 0.92
37_E 127_L 1.433 0.92
477_M 481_L 1.428 0.92
160_D 163_T 1.426 0.92
196_A 227_G 1.424 0.92
40_Y 49_R 1.423 0.92
474_S 477_M 1.423 0.92
4_V 468_T 1.419 0.92
185_V 237_L 1.418 0.92
142_L 146_N 1.412 0.92
13_A 446_F 1.401 0.91
203_S 219_S 1.396 0.91
5_I 463_H 1.384 0.90
407_A 422_V 1.378 0.90
429_S 432_L 1.367 0.90
60_G 115_F 1.366 0.90
207_L 213_R 1.357 0.89
457_L 462_A 1.356 0.89
25_L 29_L 1.354 0.89
106_L 136_G 1.352 0.89
273_A 285_A 1.346 0.89
473_F 477_M 1.346 0.89
87_Y 166_M 1.346 0.89
205_W 209_R 1.339 0.88
135_F 139_L 1.334 0.88
406_I 410_Q 1.324 0.88
405_L 409_V 1.31 0.87
118_W 126_H 1.304 0.87
229_L 233_G 1.303 0.87
231_I 235_L 1.301 0.86
145_L 180_S 1.296 0.86
33_L 52_T 1.296 0.86
311_M 376_M 1.294 0.86
18_Y 486_L 1.293 0.86
197_M 426_A 1.288 0.86
200_M 223_G 1.288 0.86
317_R 350_D 1.286 0.86
36_M 51_M 1.283 0.85
265_A 303_P 1.283 0.85
342_Q 346_G 1.281 0.85
458_P 461_S 1.277 0.85
53_R 118_W 1.266 0.84
292_L 304_V 1.263 0.84
146_N 180_S 1.257 0.84
84_Y 88_V 1.257 0.84
47_I 218_R 1.245 0.83
25_L 434_W 1.238 0.83
27_L 191_G 1.237 0.82
278_D 281_R 1.236 0.82
484_L 488_A 1.229 0.82
90_D 165_R 1.228 0.82
37_E 118_W 1.223 0.81
480_G 484_L 1.217 0.81
363_D 380_I 1.217 0.81
62_N 198_F 1.211 0.81
141_A 188_V 1.208 0.80
114_F 130_T 1.207 0.80
392_I 435_I 1.204 0.80
256_M 443_M 1.2 0.80
195_G 433_P 1.199 0.80
315_Y 319_Q 1.198 0.80
483_T 487_I 1.193 0.79
134_A 138_N 1.19 0.79
98_M 171_F 1.187 0.79
133_V 137_S 1.182 0.78
403_V 426_A 1.18 0.78
338_P 342_Q 1.166 0.77
206_Y 211_R 1.162 0.77
190_A 437_I 1.161 0.77
402_L 406_I 1.16 0.76
34_A 38_T 1.153 0.76
196_A 223_G 1.149 0.75
403_V 425_M 1.146 0.75
290_A 302_K 1.142 0.75
221_A 225_V 1.142 0.75
290_A 294_I 1.136 0.74
24_P 92_F 1.131 0.74
403_V 432_L 1.131 0.74
276_E 281_R 1.128 0.74
208_L 420_R 1.125 0.73
31_F 134_A 1.124 0.73
52_T 118_W 1.121 0.73
491_Y 495_K 1.121 0.73
208_L 427_L 1.12 0.73
242_A 295_L 1.119 0.73
415_K 418_Q 1.117 0.73
200_M 224_S 1.114 0.72
297_T 301_D 1.108 0.72
345_R 348_E 1.107 0.72
253_L 256_M 1.104 0.71
246_A 253_L 1.102 0.71
406_I 421_W 1.102 0.71
274_W 284_F 1.099 0.71
360_Y 378_G 1.097 0.71
382_Q 385_P 1.096 0.70
184_F 188_V 1.095 0.70
113_L 129_V 1.085 0.69
337_E 340_V 1.085 0.69
396_C 432_L 1.084 0.69
330_E 335_N 1.084 0.69
273_A 284_F 1.083 0.69
231_I 404_M 1.082 0.69
263_E 287_K 1.081 0.69
312_A 315_Y 1.08 0.69
160_D 167_E 1.079 0.69
138_N 188_V 1.076 0.68
334_G 337_E 1.072 0.68
48_Y 501_P 1.072 0.68
299_S 302_K 1.067 0.68
54_F 500_G 1.067 0.68
53_R 123_K 1.067 0.68
50_D 502_S 1.063 0.67
320_R 350_D 1.063 0.67
153_Y 179_V 1.062 0.67
409_V 412_L 1.059 0.67
403_V 422_V 1.057 0.66
49_R 53_R 1.057 0.66
251_V 307_L 1.055 0.66
334_G 340_V 1.051 0.66
131_W 135_F 1.045 0.65
220_F 426_A 1.043 0.65
31_F 34_A 1.037 0.64
253_L 304_V 1.031 0.64
253_L 292_L 1.03 0.64
294_I 298_H 1.027 0.63
463_H 471_L 1.025 0.63
399_L 402_L 1.025 0.63
39_I 45_K 1.025 0.63
204_A 423_L 1.019 0.62
395_G 399_L 1.016 0.62
297_T 303_P 1.014 0.62
258_G 273_A 1.014 0.62
290_A 301_D 1.012 0.62
39_I 42_V 1.009 0.61
21_L 434_W 1.009 0.61
118_W 500_G 1.009 0.61
408_L 412_L 1.007 0.61
341_L 345_R 1.007 0.61
260_W 280_E 1.007 0.61
49_R 118_W 1.005 0.61
182_V 244_E 1.005 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4m48A10.3949490.981Contact Map0.159
3mk7A40.383335.70.982Contact Map0.208
2yevA20.6693340.983Contact Map0.162
2a65A10.379427.50.983Contact Map0.239
3kp9A10.509713.50.986Contact Map0.045
1v54A20.420210.10.986Contact Map0.293
3s8fA10.43779.80.986Contact Map0.226
3o0rB10.37559.30.987Contact Map0.312
2gsmA20.43978.60.987Contact Map0.366
3qapA10.24517.60.987Contact Map0.128

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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