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ACUI - Probable acrylyl-CoA reductase AcuI
UniProt: P26646 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11315
Length: 324 (321)
Sequences: 22691
Seq/Len: 70.69

ACUI
Paralog alert: 0.83 [within 20: 0.38] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
302_E 305_N 3.481 1.00
35_H 118_A 3.297 1.00
33_D 70_R 3.205 1.00
35_H 68_T 2.993 1.00
30_V 109_L 2.914 1.00
7_E 18_Q 2.91 1.00
31_T 70_R 2.905 1.00
117_D 120_K 2.813 1.00
168_H 193_S 2.777 1.00
81_Q 111_A 2.762 1.00
149_E 173_Q 2.759 1.00
185_E 189_S 2.735 1.00
184_H 188_K 2.606 1.00
298_I 309_A 2.571 1.00
78_H 81_Q 2.568 1.00
119_R 297_E 2.533 1.00
33_D 68_T 2.439 1.00
82_E 112_M 2.392 1.00
33_D 101_Q 2.353 1.00
173_Q 194_R 2.304 1.00
150_I 167_L 2.285 1.00
5_L 18_Q 2.274 1.00
284_A 288_E 2.272 1.00
299_S 302_E 2.241 1.00
7_E 16_S 2.222 1.00
296_K 309_A 2.215 1.00
22_E 101_Q 2.204 1.00
181_E 185_E 2.181 1.00
76_R 106_G 2.166 1.00
297_E 322_K 2.135 1.00
24_R 71_T 2.107 1.00
65_F 97_G 2.081 1.00
155_A 176_A 2.07 1.00
151_V 212_W 2.059 1.00
26_P 29_D 2.056 1.00
144_R 147_D 2.053 1.00
115_G 287_P 2.045 1.00
164_V 192_A 2.039 1.00
82_E 118_A 2.027 1.00
305_N 308_E 1.99 1.00
308_E 312_N 1.981 1.00
31_T 103_R 1.973 1.00
185_E 188_K 1.943 1.00
66_A 118_A 1.928 1.00
231_M 237_V 1.916 1.00
128_G 162_T 1.908 1.00
70_R 101_Q 1.895 1.00
151_V 177_V 1.888 1.00
298_I 306_F 1.888 1.00
147_D 236_C 1.86 1.00
48_T 311_I 1.832 1.00
71_T 79_A 1.819 1.00
309_A 314_Q 1.818 1.00
65_F 85_L 1.81 1.00
112_M 121_A 1.798 1.00
184_H 195_V 1.787 1.00
136_M 170_L 1.783 1.00
181_E 197_P 1.772 1.00
213_A 232_N 1.753 1.00
236_C 261_R 1.738 1.00
2_Q 19_T 1.726 1.00
178_S 184_H 1.713 1.00
77_F 111_A 1.705 1.00
305_N 309_A 1.696 1.00
72_S 79_A 1.687 1.00
4_L 303_A 1.683 1.00
231_M 235_G 1.682 1.00
236_C 263_Q 1.679 1.00
25_L 103_R 1.676 1.00
82_E 114_Q 1.671 1.00
186_Y 189_S 1.634 1.00
231_M 260_V 1.622 1.00
112_M 118_A 1.614 1.00
69_V 77_F 1.614 1.00
153_T 227_V 1.603 1.00
29_D 105_K 1.597 1.00
169_K 290_F 1.585 1.00
175_V 212_W 1.582 1.00
68_T 82_E 1.556 1.00
215_A 227_V 1.554 1.00
200_E 203_E 1.548 1.00
28_G 105_K 1.539 1.00
2_Q 100_E 1.515 1.00
31_T 101_Q 1.503 1.00
119_R 322_K 1.498 1.00
29_D 103_R 1.495 1.00
77_F 81_Q 1.488 1.00
34_V 65_F 1.486 1.00
36_W 322_K 1.486 1.00
2_Q 301_S 1.481 1.00
30_V 77_F 1.476 1.00
31_T 71_T 1.474 1.00
3_A 20_L 1.456 1.00
141_A 214_G 1.447 1.00
173_Q 193_S 1.443 1.00
25_L 31_T 1.442 1.00
36_W 119_R 1.437 1.00
164_V 176_A 1.426 1.00
68_T 118_A 1.406 0.99
98_L 307_A 1.406 0.99
25_L 29_D 1.406 0.99
136_M 281_R 1.401 0.99
304_P 308_E 1.389 0.99
149_E 175_V 1.37 0.99
77_F 109_L 1.368 0.99
215_A 231_M 1.36 0.99
163_A 216_I 1.33 0.99
194_R 207_L 1.317 0.99
284_A 287_P 1.316 0.99
32_V 67_G 1.313 0.99
35_H 82_E 1.309 0.99
4_L 17_V 1.307 0.99
179_G 198_R 1.306 0.99
28_G 106_G 1.281 0.99
104_V 109_L 1.275 0.99
153_T 177_V 1.252 0.99
143_V 172_Y 1.24 0.98
203_E 206_P 1.232 0.98
188_K 195_V 1.221 0.98
47_I 307_A 1.2 0.98
149_E 213_A 1.195 0.98
39_L 306_F 1.179 0.98
176_A 192_A 1.178 0.98
152_V 163_A 1.176 0.98
181_E 184_H 1.174 0.98
116_L 121_A 1.172 0.98
285_D 290_F 1.168 0.97
22_E 31_T 1.167 0.97
300_L 323_V 1.152 0.97
36_W 118_A 1.151 0.97
169_K 285_D 1.13 0.97
120_K 292_T 1.125 0.97
132_M 136_M 1.116 0.96
34_V 102_A 1.113 0.96
280_Q 284_A 1.108 0.96
17_V 301_S 1.093 0.96
188_K 194_R 1.088 0.96
141_A 238_A 1.069 0.95
32_V 83_V 1.069 0.95
303_A 321_V 1.051 0.94
131_A 166_L 1.05 0.94
217_D 220_G 1.048 0.94
308_E 311_I 1.045 0.94
229_A 254_P 1.035 0.94
152_V 167_L 1.031 0.94
2_Q 17_V 1.025 0.93
281_R 284_A 1.023 0.93
70_R 79_A 1.022 0.93
4_L 300_L 1.02 0.93
78_H 111_A 1.02 0.93
47_I 311_I 1.016 0.93
299_S 322_K 1.006 0.93
33_D 100_E 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nx4A211000.024Contact Map0.743
4j6fA20.9661000.064Contact Map0.797
4a27A20.9661000.064Contact Map0.836
4dupA20.96911000.065Contact Map0.812
3uogA20.95991000.068Contact Map0.806
1tt7A60.99381000.068Contact Map0.789
4jxkA20.99381000.07Contact Map0.725
1zsyA10.97221000.073Contact Map0.745
4eyeA20.9631000.078Contact Map0.807
4gi2A20.97841000.081Contact Map0.818

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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