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CYNR - HTH-type transcriptional regulator CynR
UniProt: P27111 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11421
Length: 299 (291)
Sequences: 37280
Seq/Len: 128.11

CYNR
Paralog alert: 0.87 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_R 74_E 3.718 1.00
15_H 24_A 3.42 1.00
158_I 287_L 2.592 1.00
231_I 238_T 2.515 1.00
96_A 141_L 2.417 1.00
20_R 23_S 2.38 1.00
67_Y 81_A 2.339 1.00
164_S 242_A 2.301 1.00
14_E 69_S 2.231 1.00
173_H 189_E 2.218 1.00
182_A 185_R 2.211 1.00
11_A 24_A 2.21 1.00
94_R 123_Q 2.192 1.00
92_S 121_T 2.16 1.00
92_S 123_Q 2.133 1.00
71_A 75_L 2.13 1.00
159_P 162_T 2.116 1.00
112_D 289_K 2.111 1.00
13_A 57_L 2.095 1.00
67_Y 74_E 2.064 1.00
10_L 65_R 2.004 1.00
162_T 264_T 2 1.00
45_V 60_A 1.975 1.00
8_Y 35_Q 1.969 1.00
65_R 69_S 1.965 1.00
18_F 36_I 1.95 1.00
11_A 15_H 1.917 1.00
11_A 14_E 1.869 1.00
10_L 69_S 1.862 1.00
64_W 78_G 1.856 1.00
10_L 14_E 1.852 1.00
112_D 285_M 1.848 1.00
49_D 56_R 1.837 1.00
192_V 236_L 1.823 1.00
8_Y 32_L 1.823 1.00
159_P 264_T 1.814 1.00
113_F 120_I 1.803 1.00
166_A 242_A 1.779 1.00
13_A 65_R 1.747 1.00
59_D 62_E 1.705 1.00
190_K 218_V 1.685 1.00
169_V 254_I 1.676 1.00
10_L 68_A 1.673 1.00
134_D 138_R 1.672 1.00
14_E 24_A 1.672 1.00
9_F 65_R 1.672 1.00
63_V 81_A 1.671 1.00
132_I 144_G 1.656 1.00
19_T 29_Q 1.635 1.00
113_F 282_F 1.632 1.00
28_S 31_A 1.604 1.00
15_H 20_R 1.594 1.00
17_S 20_R 1.585 1.00
232_R 250_G 1.581 1.00
10_L 72_L 1.578 1.00
88_L 119_S 1.571 1.00
8_Y 27_V 1.561 1.00
201_R 205_D 1.527 1.00
67_Y 77_A 1.492 1.00
178_H 185_R 1.473 1.00
157_A 266_V 1.473 1.00
192_V 227_V 1.466 1.00
11_A 25_L 1.465 1.00
135_M 140_E 1.459 1.00
71_A 78_G 1.453 1.00
166_A 253_A 1.443 1.00
103_S 225_S 1.436 1.00
5_H 38_Q 1.434 1.00
46_P 49_D 1.429 1.00
112_D 116_R 1.423 1.00
5_H 42_S 1.418 1.00
143_V 279_A 1.409 1.00
5_H 35_Q 1.4 0.99
62_E 66_Q 1.396 0.99
64_W 79_K 1.382 0.99
3_S 75_L 1.373 0.99
189_E 237_S 1.362 0.99
169_V 237_S 1.352 0.99
112_D 115_A 1.351 0.99
37_R 41_E 1.348 0.99
90_R 119_S 1.334 0.99
281_A 284_H 1.332 0.99
135_M 141_L 1.325 0.99
227_V 238_T 1.322 0.99
67_Y 70_R 1.317 0.99
156_E 269_R 1.31 0.99
171_Q 250_G 1.306 0.99
275_Q 279_A 1.299 0.99
111_A 115_A 1.287 0.99
156_E 271_K 1.279 0.99
267_L 283_L 1.277 0.99
283_L 287_L 1.276 0.99
127_M 131_K 1.267 0.99
42_S 79_K 1.252 0.99
9_F 13_A 1.251 0.99
34_Q 37_R 1.251 0.99
221_A 227_V 1.235 0.98
174_P 189_E 1.233 0.98
114_Y 190_K 1.227 0.98
9_F 48_F 1.226 0.98
113_F 285_M 1.225 0.98
12_V 36_I 1.223 0.98
13_A 48_F 1.214 0.98
208_C 213_L 1.206 0.98
94_R 125_Q 1.204 0.98
66_Q 70_R 1.203 0.98
33_S 37_R 1.201 0.98
93_L 282_F 1.201 0.98
158_I 269_R 1.196 0.98
51_S 56_R 1.196 0.98
67_Y 78_G 1.196 0.98
57_L 61_G 1.192 0.98
114_Y 218_V 1.189 0.98
229_E 232_R 1.188 0.98
27_V 31_A 1.188 0.98
116_R 285_M 1.182 0.98
63_V 66_Q 1.177 0.98
242_A 246_T 1.172 0.98
9_F 47_L 1.166 0.97
181_V 185_R 1.164 0.97
162_T 261_L 1.163 0.97
18_F 55_I 1.159 0.97
137_C 154_E 1.155 0.97
12_V 21_A 1.155 0.97
74_E 77_A 1.153 0.97
284_H 287_L 1.146 0.97
7_N 76_G 1.131 0.97
11_A 21_A 1.123 0.97
280_K 284_H 1.11 0.96
143_V 267_L 1.106 0.96
116_R 288_D 1.099 0.96
35_Q 38_Q 1.098 0.96
171_Q 252_K 1.096 0.96
170_A 234_T 1.095 0.96
269_R 283_L 1.092 0.96
146_A 268_L 1.092 0.96
63_V 67_Y 1.079 0.95
229_E 233_R 1.077 0.95
167_L 237_S 1.073 0.95
6_I 68_A 1.072 0.95
4_R 7_N 1.071 0.95
163_E 243_A 1.07 0.95
113_F 117_Y 1.07 0.95
111_A 233_R 1.069 0.95
34_Q 38_Q 1.067 0.95
159_P 266_V 1.058 0.95
27_V 32_L 1.056 0.95
95_I 143_V 1.054 0.95
117_Y 281_A 1.052 0.95
48_F 55_I 1.051 0.94
169_V 173_H 1.05 0.94
96_A 146_A 1.049 0.94
71_A 74_E 1.044 0.94
70_R 77_A 1.044 0.94
123_Q 220_E 1.039 0.94
2_L 5_H 1.037 0.94
76_G 80_R 1.035 0.94
228_L 232_R 1.033 0.94
64_W 68_A 1.032 0.94
173_H 190_K 1.031 0.94
190_K 216_Q 1.02 0.93
158_I 283_L 1.018 0.93
136_L 144_G 1.018 0.93
157_A 268_L 1.012 0.93
168_V 245_A 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2h98A20.991000.075Contact Map0.771
2esnA40.98331000.077Contact Map0.775
1ixcA20.96991000.079Contact Map0.766
1al3A111000.08Contact Map0.755
1uthA10.99671000.082Contact Map0.756
2h9bA20.991000.087Contact Map0.757
3fxqA20.991000.091Contact Map0.79
3fzvA40.991000.092Contact Map0.727
3szpA20.96321000.113Contact Map0.76
3hhgA80.98661000.13Contact Map0.927

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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