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ARGK - Probable GTPase ArgK
UniProt: P27254 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11445
Length: 331 (321)
Sequences: 857
Seq/Len: 2.67

ARGK
Paralog alert: 0.15 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
15_R 50_Y 4.311 1.00
79_I 114_A 3.914 1.00
22_L 141_L 3.773 1.00
306_A 311_T 2.74 1.00
10_S 21_T 2.437 1.00
65_A 176_I 2.415 1.00
88_I 138_L 2.404 1.00
13_R 18_E 2.378 1.00
76_M 114_A 2.279 1.00
199_I 214_R 2.162 1.00
290_L 321_L 2.113 1.00
13_R 21_T 2.111 1.00
75_G 87_V 2.105 1.00
51_C 140_L 2.1 1.00
268_Q 271_Q 2.098 1.00
170_C 256_F 2.091 1.00
79_I 116_A 2.001 0.99
173_S 191_M 1.946 0.99
257_K 261_T 1.913 0.99
8_A 46_A 1.91 0.99
139_M 152_V 1.905 0.99
11_I 43_L 1.86 0.99
170_C 196_L 1.843 0.99
59_V 172_I 1.776 0.99
172_I 198_V 1.774 0.99
14_L 25_A 1.771 0.98
57_L 74_F 1.758 0.98
303_T 317_G 1.741 0.98
70_F 249_I 1.735 0.98
83_L 148_D 1.735 0.98
283_E 287_L 1.713 0.98
11_I 46_A 1.685 0.98
22_L 142_C 1.663 0.97
122_V 138_L 1.656 0.97
72_E 110_D 1.641 0.97
84_K 116_A 1.629 0.97
252_A 255_D 1.614 0.97
319_R 323_E 1.606 0.97
65_A 174_L 1.577 0.96
6_T 9_E 1.571 0.96
178_G 206_N 1.557 0.96
75_G 111_L 1.514 0.95
306_A 320_Q 1.484 0.94
22_L 147_Y 1.462 0.94
25_A 43_L 1.456 0.93
49_P 52_G 1.42 0.92
76_M 110_D 1.391 0.91
172_I 249_I 1.389 0.91
27_T 31_S 1.381 0.91
191_M 217_Y 1.38 0.91
80_R 114_A 1.378 0.91
176_I 179_G 1.378 0.91
77_L 246_I 1.377 0.91
251_H 255_D 1.372 0.90
307_V 317_G 1.37 0.90
20_A 23_A 1.364 0.90
77_L 247_D 1.36 0.90
83_L 149_V 1.344 0.89
18_E 319_R 1.343 0.89
12_R 16_Q 1.342 0.89
76_M 79_I 1.342 0.89
14_L 47_I 1.339 0.89
177_A 206_N 1.331 0.89
55_L 257_K 1.324 0.88
305_L 309_N 1.317 0.88
7_L 39_L 1.314 0.88
299_Y 302_Q 1.299 0.87
29_V 141_L 1.297 0.87
175_Q 217_Y 1.288 0.86
106_T 183_L 1.285 0.86
178_G 204_G 1.282 0.86
299_Y 320_Q 1.282 0.86
38_A 42_Q 1.28 0.86
78_L 85_V 1.273 0.85
238_C 249_I 1.273 0.85
14_L 141_L 1.273 0.85
57_L 151_I 1.267 0.85
206_N 209_N 1.267 0.85
65_A 289_H 1.261 0.85
65_A 213_A 1.257 0.84
70_F 238_C 1.255 0.84
198_V 249_I 1.245 0.84
318_L 322_S 1.244 0.84
86_A 147_Y 1.243 0.84
101_I 136_R 1.228 0.83
314_P 318_L 1.222 0.82
62_T 176_I 1.217 0.82
27_T 30_E 1.214 0.82
81_E 254_I 1.211 0.81
258_T 262_A 1.21 0.81
77_L 81_E 1.2 0.80
214_R 237_T 1.193 0.80
54_T 143_E 1.191 0.80
222_H 232_Q 1.189 0.80
75_G 117_A 1.186 0.79
111_L 119_I 1.184 0.79
133_Q 284_E 1.183 0.79
26_M 145_A 1.173 0.78
10_S 43_L 1.163 0.78
60_T 178_G 1.162 0.77
105_K 121_P 1.162 0.77
104_D 161_E 1.144 0.76
101_I 186_I 1.139 0.75
258_T 302_Q 1.138 0.75
78_L 151_I 1.133 0.75
122_V 132_S 1.128 0.74
177_A 238_C 1.127 0.74
97_T 238_C 1.127 0.74
85_V 151_I 1.126 0.74
209_N 212_I 1.124 0.74
256_F 260_L 1.121 0.74
57_L 253_I 1.118 0.73
78_L 250_W 1.117 0.73
231_W 256_F 1.11 0.73
19_R 27_T 1.102 0.72
302_Q 305_L 1.096 0.71
235_V 239_S 1.095 0.71
305_L 323_E 1.093 0.71
70_F 174_L 1.093 0.71
80_R 247_D 1.089 0.71
218_E 222_H 1.088 0.71
214_R 218_E 1.081 0.70
282_T 318_L 1.08 0.70
149_V 250_W 1.079 0.70
169_D 270_R 1.079 0.70
72_E 198_V 1.079 0.70
299_Y 324_F 1.073 0.69
81_E 251_H 1.072 0.69
73_A 240_A 1.071 0.69
79_I 85_V 1.071 0.69
285_E 319_R 1.07 0.69
172_I 196_L 1.069 0.69
281_Q 284_E 1.067 0.68
285_E 289_H 1.066 0.68
29_V 82_G 1.062 0.68
306_A 312_L 1.06 0.68
200_N 240_A 1.06 0.68
236_L 252_A 1.059 0.68
317_G 322_S 1.059 0.68
268_Q 305_L 1.057 0.67
22_L 145_A 1.055 0.67
25_A 141_L 1.049 0.67
296_F 325_I 1.047 0.66
71_L 151_I 1.046 0.66
306_A 309_N 1.045 0.66
179_G 206_N 1.041 0.66
254_I 258_T 1.03 0.64
234_R 256_F 1.03 0.64
72_E 105_K 1.027 0.64
93_S 124_S 1.022 0.64
312_L 317_G 1.016 0.63
124_S 157_V 1.011 0.62
20_A 162_T 1.004 0.62
234_R 255_D 1.002 0.61
24_Q 178_G 1.002 0.61
88_I 118_F 1 0.61
313_S 316_T 1 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2wwwA40.99091000.493Contact Map0.742
2p67A111000.554Contact Map0.734
2qm8A211000.557Contact Map0.637
3p32A10.9941000.593Contact Map0.679
2j69A40.96681000.745Contact Map0.376
2wsmA20.667799.90.801Contact Map0.558
2x2eA20.885299.90.805Contact Map0.252
2akaB10.773499.90.808Contact Map0.264
4hi0E20.57199.90.812Contact Map0.566
3t34A20.879299.90.816Contact Map0.13

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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