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ACSA - Acetyl-coenzyme A synthetase
UniProt: P27550 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11448
Length: 652 (605)
Sequences: 16154
Seq/Len: 26.70

ACSA
Paralog alert: 0.80 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: ACSA CAIC ENTE FADK LCFA MENE PRPE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
129_I 157_A 4.282 1.00
258_P 275_L 4.149 1.00
464_L 502_A 4.091 1.00
177_D 263_Y 3.6 1.00
445_Q 467_T 3.536 1.00
450_D 454_N 3.394 1.00
133_D 181_R 3.201 1.00
181_R 215_E 3.111 1.00
136_A 180_S 3.104 1.00
93_T 107_H 3.017 1.00
179_N 479_G 3.014 1.00
118_C 154_R 2.998 1.00
447_A 455_P 2.924 1.00
521_N 526_R 2.899 1.00
148_A 184_I 2.894 1.00
277_T 475_R 2.778 1.00
480_D 483_R 2.756 1.00
299_D 381_R 2.659 1.00
544_E 604_K 2.617 1.00
503_R 511_W 2.603 1.00
344_Q 348_K 2.558 1.00
481_H 485_E 2.531 1.00
536_L 561_A 2.479 1.00
482_E 486_Q 2.391 1.00
120_F 151_A 2.367 1.00
134_V 160_S 2.353 1.00
91_D 111_K 2.352 1.00
83_D 114_H 2.339 1.00
436_S 511_W 2.331 1.00
120_F 147_V 2.33 1.00
177_D 480_D 2.316 1.00
461_E 501_G 2.314 1.00
483_R 486_Q 2.313 1.00
541_K 578_E 2.284 1.00
123_T 240_L 2.276 1.00
93_T 109_S 2.275 1.00
131_K 257_D 2.255 1.00
89_N 92_R 2.253 1.00
96_I 326_T 2.247 1.00
116_D 147_V 2.245 1.00
111_K 115_R 2.235 1.00
522_V 527_L 2.224 1.00
129_I 182_L 2.222 1.00
114_H 154_R 2.208 1.00
449_V 465_V 2.153 1.00
504_R 510_Y 2.141 1.00
125_L 155_I 2.125 1.00
350_Q 379_S 2.124 1.00
135_V 152_C 2.12 1.00
447_A 465_V 2.116 1.00
152_C 157_A 2.11 1.00
484_F 488_Y 2.104 1.00
539_H 582_W 2.085 1.00
114_H 118_C 2.08 1.00
135_V 157_A 2.074 1.00
396_E 400_K 2.074 1.00
94_A 113_L 2.058 1.00
537_V 545_A 2.056 1.00
433_K 507_D 2.041 1.00
547_V 561_A 2.034 1.00
448_L 502_A 2.032 1.00
300_I 326_T 2.024 1.00
254_N 257_D 2.018 1.00
560_Y 597_H 2.017 1.00
611_M 614_I 2.007 1.00
120_F 184_I 2.003 1.00
463_S 497_F 2.003 1.00
92_R 298_G 1.985 1.00
346_V 379_S 1.984 1.00
117_V 151_A 1.96 1.00
153_A 259_L 1.956 1.00
134_V 478_F 1.942 1.00
465_V 497_F 1.94 1.00
108_I 147_V 1.913 1.00
275_L 476_T 1.904 1.00
129_I 135_V 1.9 1.00
415_Q 496_Y 1.872 1.00
123_T 127_L 1.87 1.00
151_A 155_I 1.863 1.00
90_G 111_K 1.855 1.00
96_I 107_H 1.841 1.00
112_E 115_R 1.839 1.00
328_L 351_V 1.831 1.00
577_A 581_N 1.821 1.00
392_P 396_E 1.809 1.00
541_K 569_E 1.803 1.00
280_G 473_Q 1.785 1.00
172_A 176_I 1.779 1.00
34_V 37_T 1.776 1.00
450_D 456_L 1.773 1.00
538_A 586_E 1.767 1.00
107_H 349_H 1.764 1.00
299_D 352_N 1.749 1.00
115_R 119_R 1.743 1.00
85_H 89_N 1.738 1.00
136_A 175_I 1.73 1.00
96_I 349_H 1.726 1.00
236_W 239_D 1.714 1.00
29_Q 33_N 1.713 1.00
84_R 88_E 1.702 1.00
86_L 114_H 1.696 1.00
614_I 617_K 1.695 1.00
173_G 270_K 1.684 1.00
536_L 545_A 1.682 1.00
502_A 512_I 1.681 1.00
562_Y 615_L 1.662 1.00
178_S 263_Y 1.656 1.00
140_P 186_S 1.651 1.00
300_I 351_V 1.65 1.00
130_K 133_D 1.646 1.00
584_R 592_T 1.619 1.00
127_L 216_H 1.616 1.00
97_W 143_P 1.612 1.00
487_T 496_Y 1.601 1.00
116_D 119_R 1.598 1.00
93_T 96_I 1.594 1.00
109_S 112_E 1.591 1.00
347_D 375_T 1.59 1.00
418_T 496_Y 1.589 1.00
117_V 154_R 1.575 1.00
446_P 510_Y 1.572 1.00
356_T 361_I 1.569 1.00
306_D 309_W 1.567 1.00
118_C 122_N 1.564 1.00
446_P 466_I 1.555 1.00
158_V 258_P 1.553 1.00
466_I 498_S 1.551 1.00
183_V 202_V 1.55 1.00
457_E 460_T 1.547 1.00
258_P 475_R 1.545 1.00
505_D 511_W 1.541 1.00
531_E 591_A 1.538 1.00
564_T 602_L 1.536 1.00
177_D 479_G 1.523 1.00
162_I 171_V 1.512 1.00
136_A 162_I 1.502 1.00
113_L 150_L 1.5 1.00
385_S 390_I 1.491 1.00
108_I 143_P 1.485 1.00
505_D 509_Y 1.475 1.00
580_R 596_L 1.474 1.00
484_F 487_T 1.469 1.00
264_T 274_V 1.466 1.00
448_L 456_L 1.464 1.00
120_F 148_A 1.458 1.00
422_M 466_I 1.441 1.00
124_L 182_L 1.434 1.00
146_A 317_L 1.432 1.00
581_N 585_K 1.426 1.00
444_V 472_G 1.416 1.00
115_R 246_D 1.413 1.00
261_I 478_F 1.405 0.99
182_L 216_H 1.403 0.99
265_S 607_S 1.397 0.99
579_V 596_L 1.387 0.99
263_Y 273_G 1.378 0.99
576_Y 580_R 1.378 0.99
320_P 325_A 1.373 0.99
341_R 344_Q 1.37 0.99
539_H 579_V 1.367 0.99
605_T 611_M 1.366 0.99
296_H 299_D 1.366 0.99
458_G 504_R 1.363 0.99
539_H 578_E 1.362 0.99
485_E 488_Y 1.361 0.99
584_R 589_P 1.355 0.99
132_G 257_D 1.346 0.99
258_P 277_T 1.343 0.99
122_N 245_S 1.341 0.99
106_K 116_D 1.335 0.99
82_L 86_L 1.333 0.99
280_G 419_G 1.327 0.99
550_I 595_V 1.327 0.99
255_A 279_G 1.322 0.99
461_E 503_R 1.321 0.99
256_E 279_G 1.321 0.99
302_W 351_V 1.318 0.99
93_T 326_T 1.314 0.99
361_I 383_L 1.31 0.99
450_D 460_T 1.31 0.99
543_A 566_N 1.308 0.99
433_K 509_Y 1.306 0.99
253_M 257_D 1.305 0.99
550_I 560_Y 1.299 0.99
124_L 184_I 1.297 0.99
277_T 280_G 1.297 0.99
423_I 510_Y 1.284 0.99
582_W 585_K 1.284 0.99
30_Q 41_E 1.279 0.99
390_I 395_W 1.278 0.99
467_T 495_M 1.277 0.99
139_M 220_L 1.276 0.99
120_F 124_L 1.271 0.99
299_D 353_I 1.269 0.99
126_E 244_A 1.267 0.99
276_H 280_G 1.264 0.99
176_I 270_K 1.261 0.99
160_S 178_S 1.26 0.99
582_W 586_E 1.258 0.99
501_G 514_G 1.256 0.99
565_L 598_W 1.255 0.99
113_L 147_V 1.25 0.99
52_Y 55_V 1.245 0.98
127_L 240_L 1.244 0.98
391_N 394_A 1.239 0.98
106_K 144_E 1.238 0.98
320_P 327_T 1.236 0.98
548_V 562_Y 1.233 0.98
530_A 534_S 1.223 0.98
520_L 559_I 1.222 0.98
108_I 116_D 1.218 0.98
170_A 591_A 1.218 0.98
464_L 512_I 1.215 0.98
350_Q 376_D 1.213 0.98
108_I 113_L 1.212 0.98
489_F 493_K 1.211 0.98
538_A 582_W 1.21 0.98
119_R 246_D 1.208 0.98
459_A 506_E 1.207 0.98
86_L 90_G 1.202 0.98
113_L 117_V 1.2 0.98
150_L 321_L 1.197 0.98
518_D 612_R 1.195 0.98
501_G 516_V 1.193 0.98
173_G 177_D 1.192 0.98
114_H 117_V 1.191 0.98
461_E 513_T 1.19 0.98
488_Y 497_F 1.189 0.98
130_K 181_R 1.187 0.98
535_A 583_V 1.182 0.98
123_T 244_A 1.181 0.98
143_P 147_V 1.181 0.98
92_R 326_T 1.179 0.98
482_E 485_E 1.174 0.98
397_W 401_K 1.172 0.98
95_I 146_A 1.17 0.97
129_I 155_I 1.169 0.97
433_K 505_D 1.165 0.97
347_D 376_D 1.165 0.97
83_D 154_R 1.16 0.97
583_V 592_T 1.157 0.97
386_V 412_T 1.154 0.97
299_D 325_A 1.152 0.97
134_V 179_N 1.149 0.97
468_D 473_Q 1.149 0.97
489_F 497_F 1.146 0.97
446_P 464_L 1.146 0.97
576_Y 598_W 1.132 0.97
105_S 348_K 1.123 0.97
147_V 237_W 1.123 0.97
124_L 152_C 1.121 0.97
137_I 148_A 1.12 0.96
440_P 446_P 1.12 0.96
456_L 460_T 1.115 0.96
158_V 478_F 1.112 0.96
572_S 578_E 1.112 0.96
274_V 474_A 1.11 0.96
474_A 488_Y 1.11 0.96
580_R 584_R 1.105 0.96
338_T 341_R 1.105 0.96
261_I 273_G 1.103 0.96
305_A 311_T 1.1 0.96
116_D 144_E 1.098 0.96
110_Y 325_A 1.089 0.96
340_A 344_Q 1.087 0.96
142_V 220_L 1.087 0.96
187_D 221_K 1.086 0.96
147_V 151_A 1.082 0.96
175_I 180_S 1.081 0.95
588_G 591_A 1.081 0.95
578_E 581_N 1.08 0.95
300_I 328_L 1.075 0.95
340_A 375_T 1.075 0.95
172_A 208_N 1.073 0.95
533_E 547_V 1.068 0.95
542_I 579_V 1.067 0.95
259_L 278_T 1.064 0.95
95_I 143_P 1.063 0.95
85_H 88_E 1.062 0.95
447_A 495_M 1.061 0.95
152_C 159_H 1.059 0.95
519_V 528_G 1.059 0.95
449_V 455_P 1.058 0.95
366_A 397_W 1.056 0.95
439_R 509_Y 1.055 0.95
398_Y 402_I 1.053 0.95
95_I 108_I 1.052 0.95
403_G 406_K 1.045 0.94
560_Y 595_V 1.044 0.94
503_R 513_T 1.044 0.94
120_F 237_W 1.037 0.94
345_V 349_H 1.035 0.94
173_G 263_Y 1.035 0.94
74_T 254_N 1.035 0.94
602_L 610_I 1.033 0.94
311_T 355_Y 1.031 0.94
523_S 555_K 1.03 0.94
133_D 157_A 1.03 0.94
121_A 155_I 1.028 0.94
53_Q 72_D 1.025 0.93
562_Y 599_T 1.024 0.93
552_H 558_A 1.019 0.93
168_P 204_D 1.017 0.93
354_L 380_L 1.016 0.93
125_L 251_E 1.011 0.93
121_A 154_R 1.011 0.93
347_D 378_S 1.01 0.93
464_L 510_Y 1.007 0.93
558_A 594_D 1.007 0.93
116_D 241_V 1.006 0.93
94_A 110_Y 1.002 0.92
330_F 345_V 1.002 0.92
535_A 586_E 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pg4A211000.098Contact Map0.785
1ry2A10.98931000.141Contact Map0.729
2vsqA10.89571000.237Contact Map0.725
1amuA20.84511000.269Contact Map0.821
3etcA20.87421000.271Contact Map0.834
3tsyA10.91871000.282Contact Map0.772
3g7sA20.82671000.283Contact Map0.798
4dg8A10.81441000.284Contact Map0.699
4iz6A20.87731000.284Contact Map0.739
1mdbA10.82211000.287Contact Map0.765

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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