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NARQ - Nitrate/nitrite sensor protein NarQ
UniProt: P27896 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11460
Length: 566 (557)
Sequences: 569
Seq/Len: 1.02

NARQ
Paralog alert: 0.47 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: NARQ NARX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
488_S 509_N 2.651 1.00
206_N 209_G 2.255 0.98
189_R 194_Q 2.231 0.98
507_R 550_L 2.141 0.97
204_L 209_G 2.134 0.97
481_A 490_I 2.015 0.96
473_I 532_A 1.741 0.89
543_Q 546_G 1.68 0.87
452_T 491_A 1.66 0.86
544_P 547_G 1.654 0.86
543_Q 547_G 1.633 0.85
198_P 216_N 1.596 0.83
326_V 329_S 1.594 0.83
476_E 531_R 1.593 0.83
485_A 509_N 1.574 0.82
528_M 539_L 1.571 0.82
504_V 553_I 1.536 0.80
75_Q 110_N 1.535 0.79
476_E 528_M 1.533 0.79
450_K 489_E 1.481 0.76
489_E 509_N 1.475 0.76
47_G 50_R 1.461 0.75
366_A 375_Q 1.461 0.75
229_L 418_E 1.456 0.74
235_E 506_I 1.453 0.74
299_N 304_M 1.438 0.73
367_R 523_Y 1.435 0.73
543_Q 549_T 1.435 0.73
476_E 522_H 1.429 0.72
473_I 531_R 1.428 0.72
368_E 472_Q 1.427 0.72
344_L 492_V 1.422 0.72
469_H 523_Y 1.415 0.71
474_I 504_V 1.411 0.71
367_R 376_V 1.408 0.71
74_F 128_Y 1.407 0.71
270_I 280_A 1.405 0.70
209_G 212_A 1.395 0.70
33_L 36_S 1.394 0.70
531_R 535_L 1.393 0.69
200_L 212_A 1.378 0.68
186_A 215_F 1.374 0.68
370_H 476_E 1.365 0.67
76_Q 152_A 1.361 0.67
358_L 361_E 1.359 0.67
44_N 47_G 1.35 0.66
490_I 504_V 1.348 0.66
367_R 422_T 1.339 0.65
257_L 271_L 1.335 0.65
366_A 412_A 1.332 0.64
130_N 156_A 1.33 0.64
528_M 531_R 1.329 0.64
370_H 531_R 1.329 0.64
420_L 423_F 1.325 0.64
362_R 370_H 1.323 0.64
215_F 218_M 1.321 0.64
443_L 481_A 1.316 0.63
100_A 162_F 1.312 0.63
370_H 375_Q 1.31 0.63
44_N 51_M 1.31 0.63
228_S 439_M 1.308 0.62
472_Q 475_R 1.298 0.62
424_R 469_H 1.296 0.61
198_P 220_S 1.293 0.61
522_H 528_M 1.29 0.61
222_L 529_R 1.283 0.60
367_R 476_E 1.28 0.60
416_L 469_H 1.272 0.59
370_H 423_F 1.271 0.59
370_H 383_Q 1.271 0.59
29_A 33_L 1.27 0.59
513_I 543_Q 1.268 0.59
11_L 171_R 1.265 0.59
49_L 52_Q 1.261 0.58
247_L 417_R 1.256 0.58
74_F 78_L 1.252 0.57
523_Y 551_V 1.248 0.57
416_L 472_Q 1.246 0.57
65_P 76_Q 1.245 0.57
522_H 531_R 1.244 0.57
381_R 416_L 1.244 0.57
473_I 490_I 1.243 0.57
484_H 522_H 1.241 0.56
477_A 551_V 1.238 0.56
540_T 554_S 1.237 0.56
532_A 553_I 1.233 0.56
340_L 446_Q 1.233 0.56
388_K 406_S 1.232 0.56
424_R 447_T 1.225 0.55
52_Q 55_R 1.224 0.55
162_F 174_H 1.224 0.55
475_R 535_L 1.221 0.55
416_L 422_T 1.221 0.55
477_A 531_R 1.219 0.54
71_R 74_F 1.208 0.53
375_Q 412_A 1.207 0.53
491_A 507_R 1.204 0.53
367_R 370_H 1.203 0.53
385_T 555_F 1.201 0.53
422_T 475_R 1.199 0.52
367_R 468_V 1.196 0.52
372_S 522_H 1.194 0.52
386_L 425_L 1.189 0.52
371_D 476_E 1.189 0.52
375_Q 476_E 1.188 0.51
476_E 485_A 1.184 0.51
44_N 53_S 1.182 0.51
452_T 489_E 1.177 0.50
383_Q 522_H 1.175 0.50
175_Q 368_E 1.174 0.50
415_Q 422_T 1.172 0.50
437_R 494_C 1.171 0.50
429_Q 436_L 1.169 0.50
436_L 492_V 1.169 0.50
412_A 421_T 1.168 0.50
491_A 509_N 1.167 0.49
361_E 375_Q 1.167 0.49
408_A 419_L 1.163 0.49
422_T 472_Q 1.161 0.49
416_L 425_L 1.159 0.49
219_S 419_L 1.158 0.49
367_R 522_H 1.155 0.48
477_A 522_H 1.154 0.48
412_A 415_Q 1.152 0.48
423_F 522_H 1.152 0.48
139_L 373_L 1.15 0.48
11_L 222_L 1.148 0.48
473_I 535_L 1.148 0.48
370_H 412_A 1.147 0.48
415_Q 469_H 1.145 0.47
7_V 10_S 1.144 0.47
53_S 56_L 1.144 0.47
383_Q 409_L 1.144 0.47
376_V 551_V 1.144 0.47
358_L 373_L 1.143 0.47
484_H 511_I 1.139 0.47
44_N 136_V 1.139 0.47
368_E 422_T 1.138 0.47
477_A 528_M 1.137 0.47
375_Q 523_Y 1.137 0.47
193_G 397_T 1.132 0.46
419_L 494_C 1.131 0.46
108_E 141_H 1.128 0.46
375_Q 383_Q 1.128 0.46
408_A 413_Y 1.126 0.46
235_E 238_R 1.122 0.45
106_W 135_F 1.121 0.45
466_M 484_H 1.121 0.45
375_Q 423_F 1.119 0.45
532_A 535_L 1.118 0.45
367_R 375_Q 1.118 0.45
366_A 417_R 1.118 0.45
177_V 212_A 1.114 0.45
472_Q 527_I 1.113 0.44
415_Q 523_Y 1.112 0.44
102_L 364_T 1.107 0.44
485_A 488_S 1.107 0.44
59_D 499_D 1.105 0.44
374_A 522_H 1.105 0.44
298_P 322_Q 1.104 0.44
222_L 271_L 1.103 0.44
152_A 156_A 1.101 0.43
416_L 475_R 1.101 0.43
415_Q 423_F 1.098 0.43
71_R 110_N 1.096 0.43
367_R 477_A 1.094 0.43
369_L 387_L 1.092 0.43
522_H 551_V 1.091 0.42
93_E 499_D 1.091 0.42
526_N 553_I 1.091 0.42
474_I 490_I 1.09 0.42
469_H 475_R 1.09 0.42
417_R 476_E 1.09 0.42
381_R 385_T 1.09 0.42
270_I 339_M 1.088 0.42
47_G 51_M 1.085 0.42
383_Q 424_R 1.085 0.42
476_E 551_V 1.084 0.42
27_G 536_G 1.084 0.42
374_A 423_F 1.082 0.42
102_L 271_L 1.082 0.42
190_I 195_F 1.081 0.42
195_F 226_Y 1.081 0.42
408_A 411_D 1.081 0.42
69_A 117_D 1.081 0.42
379_Y 422_T 1.08 0.41
371_D 531_R 1.079 0.41
135_F 139_L 1.079 0.41
367_R 415_Q 1.079 0.41
237_T 423_F 1.077 0.41
21_L 46_A 1.076 0.41
366_A 421_T 1.076 0.41
372_S 423_F 1.075 0.41
40_A 136_V 1.072 0.41
29_A 157_G 1.072 0.41
376_V 523_Y 1.071 0.41
375_Q 477_A 1.07 0.41
163_T 448_S 1.069 0.40
48_S 356_L 1.068 0.40
370_H 522_H 1.068 0.40
226_Y 230_E 1.067 0.40
76_Q 506_I 1.066 0.40
432_L 436_L 1.066 0.40
408_A 472_Q 1.065 0.40
381_R 409_L 1.065 0.40
476_E 523_Y 1.065 0.40
266_C 344_L 1.064 0.40
387_L 420_L 1.062 0.40
376_V 522_H 1.061 0.40
165_V 190_I 1.061 0.40
383_Q 423_F 1.059 0.40
365_I 527_I 1.059 0.40
68_N 163_T 1.056 0.39
218_M 484_H 1.055 0.39
19_V 60_L 1.054 0.39
362_R 475_R 1.051 0.39
43_I 47_G 1.049 0.39
4_K 7_V 1.049 0.39
100_A 486_N 1.049 0.39
366_A 528_M 1.048 0.39
375_Q 522_H 1.048 0.39
281_E 514_G 1.048 0.39
317_G 411_D 1.045 0.38
195_F 356_L 1.045 0.38
376_V 476_E 1.045 0.38
198_P 212_A 1.044 0.38
104_A 163_T 1.044 0.38
94_A 473_I 1.043 0.38
180_L 423_F 1.043 0.38
22_S 25_S 1.043 0.38
367_R 371_D 1.042 0.38
415_Q 418_E 1.042 0.38
169_L 437_R 1.041 0.38
180_L 200_L 1.041 0.38
212_A 470_L 1.04 0.38
161_I 474_I 1.039 0.38
367_R 531_R 1.039 0.38
425_L 475_R 1.037 0.38
150_V 154_S 1.037 0.38
170_R 174_H 1.037 0.38
159_I 500_G 1.035 0.37
153_I 506_I 1.032 0.37
362_R 375_Q 1.032 0.37
440_L 451_L 1.032 0.37
194_Q 208_L 1.031 0.37
21_L 85_N 1.031 0.37
366_A 423_F 1.03 0.37
370_H 417_R 1.029 0.37
417_R 528_M 1.029 0.37
370_H 477_A 1.029 0.37
269_H 343_G 1.028 0.37
371_D 522_H 1.027 0.37
375_Q 417_R 1.027 0.37
476_E 484_H 1.026 0.37
415_Q 425_L 1.025 0.37
7_V 41_E 1.025 0.37
423_F 484_H 1.025 0.37
52_Q 106_W 1.024 0.36
40_A 140_Q 1.023 0.36
371_D 375_Q 1.023 0.36
413_Y 423_F 1.023 0.36
74_F 387_L 1.023 0.36
113_L 125_I 1.022 0.36
381_R 413_Y 1.021 0.36
218_M 419_L 1.02 0.36
370_H 484_H 1.02 0.36
508_D 512_G 1.019 0.36
366_A 484_H 1.018 0.36
366_A 370_H 1.017 0.36
468_V 472_Q 1.017 0.36
50_R 54_Y 1.015 0.36
425_L 523_Y 1.014 0.36
341_G 404_D 1.014 0.36
309_V 312_Q 1.013 0.36
21_L 34_A 1.012 0.35
11_L 504_V 1.011 0.35
129_V 133_D 1.01 0.35
382_I 475_R 1.009 0.35
146_K 211_L 1.008 0.35
133_D 136_V 1.008 0.35
97_T 100_A 1.008 0.35
68_N 499_D 1.008 0.35
364_T 408_A 1.007 0.35
365_I 378_S 1.004 0.35
11_L 25_S 1.004 0.35
101_H 491_A 1.004 0.35
367_R 412_A 1.004 0.35
417_R 531_R 1.004 0.35
476_E 535_L 1.004 0.35
11_L 235_E 1.004 0.35
443_L 447_T 1.004 0.35
179_P 531_R 1.003 0.35
371_D 528_M 1.003 0.35
44_N 50_R 1.002 0.35
419_L 424_R 1.001 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.68021000.627Contact Map0.33
3a0rA10.53531000.727Contact Map0.23
3ehhA20.38521000.729Contact Map0.269
4gczA20.56541000.733Contact Map0.246
4ew8A20.42231000.745Contact Map0.317
2c2aA10.38521000.749Contact Map0.237
3jz3A20.34631000.749Contact Map0.412
3d36A20.37631000.75Contact Map0.323
2btzA10.50881000.75Contact Map0.228
4e01A10.58131000.75Contact Map0.205

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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