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ALR2 - Alanine racemase, catabolic
UniProt: P29012 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11408
Length: 356 (354)
Sequences: 2185
Seq/Len: 6.17

ALR2
Paralog alert: 0.34 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ALR1 ALR2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
14_L 232_V 4.235 1.00
158_S 189_L 3.675 1.00
266_G 308_L 3.275 1.00
239_I 266_G 3.049 1.00
64_A 96_L 3.013 1.00
250_R 255_G 2.946 1.00
285_P 292_R 2.896 1.00
292_R 331_D 2.868 1.00
192_S 211_I 2.804 1.00
244_T 264_R 2.778 1.00
65_I 94_H 2.71 1.00
246_K 262_E 2.578 1.00
265_I 296_V 2.571 1.00
236_S 319_P 2.544 1.00
21_V 211_I 2.537 1.00
256_R 298_T 2.534 1.00
347_L 351_V 2.501 1.00
250_R 258_T 2.463 1.00
237_S 268_V 2.456 1.00
321_E 326_E 2.409 1.00
293_T 311_C 2.399 1.00
235_L 270_A 2.368 1.00
257_Y 263_Q 2.319 1.00
91_Y 98_T 2.317 1.00
288_V 306_V 2.308 1.00
261_D 310_P 2.275 1.00
252_G 300_S 2.245 1.00
125_N 129_N 2.237 1.00
129_N 249_E 2.235 1.00
177_E 203_F 2.233 1.00
245_L 259_A 2.208 1.00
16_Q 230_R 2.178 1.00
10_D 13_A 2.176 1.00
33_V 57_A 2.157 1.00
246_K 259_A 2.156 1.00
29_R 54_D 2.049 1.00
37_N 349_L 2.022 1.00
286_V 306_V 2.006 1.00
8_S 236_S 1.996 1.00
276_Y 322_L 1.986 1.00
330_D 340_G 1.944 1.00
247_A 262_E 1.93 1.00
239_I 314_A 1.915 1.00
163_A 193_A 1.91 1.00
215_A 344_M 1.905 1.00
162_E 255_G 1.904 1.00
244_T 262_E 1.88 1.00
119_D 152_G 1.858 1.00
44_E 70_R 1.843 1.00
171_G 175_R 1.825 1.00
329_I 344_M 1.82 1.00
173_M 201_A 1.811 1.00
51_G 74_G 1.742 1.00
133_F 141_V 1.738 1.00
246_K 249_E 1.735 1.00
31_W 205_W 1.728 1.00
18_L 212_L 1.711 1.00
215_A 340_G 1.694 1.00
268_V 320_V 1.673 1.00
20_I 23_Q 1.672 1.00
302_D 350_R 1.663 1.00
277_P 346_A 1.639 1.00
174_A 178_Q 1.633 1.00
300_S 305_A 1.622 1.00
263_Q 309_T 1.621 1.00
242_V 308_L 1.615 1.00
47_W 67_L 1.605 1.00
315_G 318_T 1.596 0.99
121_Y 188_S 1.594 0.99
287_L 321_E 1.59 0.99
287_L 327_I 1.583 0.99
289_D 318_T 1.563 0.99
267_I 305_A 1.544 0.99
11_L 355_T 1.524 0.99
6_Q 236_S 1.52 0.99
41_H 233_M 1.517 0.99
14_L 46_I 1.509 0.99
31_W 57_A 1.504 0.99
43_I 66_T 1.501 0.99
56_F 74_G 1.497 0.99
173_M 203_F 1.49 0.99
180_A 187_R 1.488 0.99
288_V 293_T 1.483 0.99
99_C 157_M 1.469 0.99
110_Q 148_M 1.455 0.99
15_K 49_A 1.445 0.99
50_I 212_L 1.416 0.98
7_A 351_V 1.416 0.98
287_L 292_R 1.413 0.98
263_Q 307_D 1.404 0.98
239_I 308_L 1.402 0.98
261_D 309_T 1.399 0.98
97_T 154_M 1.396 0.98
171_G 174_A 1.391 0.98
268_V 304_L 1.379 0.98
5_I 237_S 1.372 0.98
239_I 242_V 1.37 0.98
51_G 56_F 1.369 0.98
162_E 169_I 1.354 0.98
233_M 323_W 1.353 0.98
16_Q 20_I 1.348 0.98
187_R 204_D 1.338 0.98
124_V 179_A 1.328 0.97
162_E 165_H 1.328 0.97
195_T 208_P 1.307 0.97
276_Y 295_T 1.307 0.97
250_R 259_A 1.304 0.97
32_S 212_L 1.301 0.97
235_L 351_V 1.299 0.97
249_E 259_A 1.287 0.97
69_E 94_H 1.272 0.96
256_R 282_T 1.261 0.96
333_A 338_T 1.247 0.96
299_V 304_L 1.24 0.96
239_I 288_V 1.24 0.96
259_A 263_Q 1.239 0.96
36_A 273_A 1.239 0.96
190_S 201_A 1.237 0.96
13_A 230_R 1.23 0.95
308_L 314_A 1.224 0.95
50_I 56_F 1.223 0.95
123_K 131_L 1.215 0.95
177_E 181_E 1.204 0.95
263_Q 296_V 1.195 0.94
260_R 263_Q 1.188 0.94
190_S 202_H 1.17 0.94
284_T 295_T 1.157 0.93
18_L 30_V 1.154 0.93
5_I 270_A 1.152 0.93
7_A 235_L 1.15 0.93
276_Y 332_V 1.149 0.93
270_A 322_L 1.148 0.93
7_A 233_M 1.146 0.93
278_R 339_V 1.144 0.93
44_E 66_T 1.138 0.92
18_L 50_I 1.137 0.92
125_N 243_Q 1.128 0.92
34_V 47_W 1.11 0.91
160_F 194_A 1.11 0.91
95_R 116_A 1.108 0.91
323_W 329_I 1.105 0.91
45_R 355_T 1.098 0.90
251_V 263_Q 1.092 0.90
287_L 326_E 1.091 0.90
238_E 319_P 1.089 0.90
293_T 309_T 1.088 0.90
45_R 48_S 1.086 0.90
22_R 54_D 1.086 0.90
20_I 24_A 1.083 0.90
16_Q 228_G 1.079 0.89
131_L 303_M 1.079 0.89
21_V 208_P 1.073 0.89
252_G 305_A 1.072 0.89
251_V 265_I 1.071 0.89
44_E 48_S 1.059 0.88
237_S 304_L 1.058 0.88
61_L 64_A 1.056 0.88
211_I 229_L 1.056 0.88
210_I 341_Y 1.038 0.87
245_L 251_V 1.038 0.87
190_S 194_A 1.037 0.87
328_K 331_D 1.029 0.86
11_L 49_A 1.029 0.86
25_A 28_A 1.026 0.86
233_M 347_L 1.022 0.86
173_M 177_E 1.021 0.86
95_R 119_D 1.013 0.85
59_L 302_D 1.01 0.85
7_A 41_H 1.004 0.84
208_P 211_I 1.003 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1bd0A20.9861000.228Contact Map0.86
3e5pA30.9861000.234Contact Map0.851
2rjgA40.99721000.241Contact Map0.83
3hurA10.98031000.244Contact Map0.663
1rcqA10.98881000.246Contact Map0.799
2vd8A20.9861000.251Contact Map0.892
3mubA20.98031000.255Contact Map0.849
4a3qA20.9861000.256Contact Map0.841
3co8A20.98311000.257Contact Map0.787
3kw3A20.9861000.26Contact Map0.798

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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