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METN - Methionine import ATP-binding protein MetN
UniProt: P30750 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11621
Length: 343 (341)
Sequences: 1968
Seq/Len: 5.77

METN
Paralog alert: 0.45 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_Q 210_C 4.954 1.00
185_D 189_R 4.815 1.00
22_N 218_E 4.409 1.00
6_N 23_N 3.741 1.00
83_Q 160_K 3.666 1.00
4_L 7_I 3.578 1.00
5_S 61_S 3.563 1.00
120_R 158_N 3.53 1.00
19_Q 22_N 3.5 1.00
3_K 27_H 3.389 1.00
126_S 131_G 3.227 1.00
104_A 117_V 3.094 1.00
32_Q 209_D 3.044 1.00
4_L 26_L 2.748 1.00
210_C 222_Q 2.738 1.00
234_T 237_A 2.635 1.00
6_N 25_S 2.633 1.00
183_L 194_I 2.607 1.00
30_A 160_K 2.603 1.00
61_S 68_E 2.586 1.00
29_P 32_Q 2.586 1.00
34_Y 212_A 2.535 1.00
100_F 121_V 2.484 1.00
117_V 121_V 2.473 1.00
51_V 195_L 2.419 1.00
224_T 227_E 2.395 1.00
35_G 208_C 2.314 1.00
113_P 116_E 2.302 1.00
120_R 123_E 2.265 1.00
68_E 71_T 2.255 1.00
65_D 160_K 2.177 1.00
8_T 23_N 2.154 1.00
3_K 63_L 2.097 1.00
97_R 108_E 1.944 1.00
34_Y 222_Q 1.933 1.00
28_V 34_Y 1.925 1.00
288_R 293_N 1.91 1.00
73_S 76_E 1.877 1.00
299_A 312_M 1.865 1.00
133_K 136_S 1.859 1.00
11_F 46_T 1.825 1.00
212_A 219_L 1.815 1.00
26_L 212_A 1.81 1.00
13_Q 16_R 1.78 1.00
21_L 214_I 1.75 1.00
104_A 121_V 1.747 1.00
53_L 56_R 1.746 1.00
124_L 156_A 1.742 1.00
94_L 105_L 1.726 1.00
36_V 195_L 1.71 1.00
24_V 219_L 1.709 1.00
9_K 55_E 1.696 1.00
89_Q 143_G 1.671 1.00
328_A 332_E 1.654 1.00
198_T 204_V 1.653 1.00
21_L 50_C 1.645 1.00
99_V 141_L 1.64 1.00
223_D 228_V 1.639 1.00
100_F 122_T 1.622 0.99
116_E 119_R 1.6 0.99
127_L 190_L 1.591 0.99
328_A 331_Q 1.576 0.99
141_L 145_Q 1.569 0.99
125_L 134_H 1.531 0.99
23_N 218_E 1.529 0.99
118_K 122_T 1.52 0.99
184_K 206_R 1.515 0.99
322_D 325_A 1.508 0.99
79_K 82_R 1.508 0.99
4_L 51_V 1.479 0.99
8_T 19_Q 1.473 0.99
63_L 68_E 1.471 0.99
8_T 22_N 1.467 0.99
100_F 135_D 1.46 0.99
164_C 208_C 1.438 0.98
6_N 59_E 1.435 0.98
324_Q 328_A 1.415 0.98
29_P 210_C 1.411 0.98
34_Y 210_C 1.399 0.98
2_I 161_V 1.399 0.98
35_G 204_V 1.361 0.98
214_I 219_L 1.358 0.98
223_D 227_E 1.335 0.97
67_Q 80_A 1.331 0.97
8_T 59_E 1.326 0.97
10_V 19_Q 1.325 0.97
185_D 188_R 1.316 0.97
3_K 66_G 1.304 0.97
5_S 63_L 1.293 0.96
5_S 25_S 1.262 0.96
115_D 119_R 1.261 0.96
36_V 47_L 1.246 0.95
288_R 291_N 1.236 0.95
271_L 335_V 1.234 0.95
80_A 161_V 1.231 0.95
67_Q 76_E 1.228 0.95
98_T 135_D 1.227 0.95
48_I 196_L 1.214 0.94
147_Q 169_S 1.213 0.94
53_L 69_L 1.209 0.94
5_S 27_H 1.207 0.94
98_T 101_G 1.18 0.93
187_N 209_D 1.177 0.93
325_A 328_A 1.173 0.93
285_E 289_R 1.171 0.93
12_H 17_T 1.141 0.92
125_L 132_D 1.134 0.91
213_V 237_A 1.123 0.91
50_C 55_E 1.119 0.91
112_T 116_E 1.119 0.91
327_I 331_Q 1.113 0.90
127_L 189_R 1.109 0.90
102_N 153_R 1.1 0.90
24_V 214_I 1.1 0.90
21_L 47_L 1.091 0.89
270_R 338_E 1.091 0.89
148_R 152_A 1.088 0.89
122_T 134_H 1.087 0.89
9_K 50_C 1.077 0.88
7_I 50_C 1.071 0.88
271_L 314_T 1.068 0.88
146_K 194_I 1.066 0.87
283_L 294_N 1.058 0.87
11_F 20_A 1.056 0.87
10_V 58_T 1.053 0.87
127_L 185_D 1.05 0.86
103_V 134_H 1.048 0.86
186_I 192_L 1.047 0.86
158_N 190_L 1.046 0.86
119_R 123_E 1.045 0.86
88_F 169_S 1.041 0.86
212_A 222_Q 1.041 0.86
318_G 326_A 1.03 0.85
4_L 62_V 1.029 0.85
147_Q 171_L 1.023 0.84
177_R 206_R 1.021 0.84
67_Q 83_Q 1.008 0.83
136_S 140_N 1.005 0.83
100_F 118_K 1.004 0.83
39_A 174_A 1.001 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC411000.179Contact Map0.871
1v43A10.94171000.315Contact Map0.764
1g29120.95631000.316Contact Map0.826
1oxxK10.94461000.317Contact Map0.738
2it1A20.94171000.319Contact Map0.788
2yyzA10.94461000.321Contact Map0.745
4fwiB10.89211000.325Contact Map0.651
3rlfA20.93881000.326Contact Map0.76
1z47A20.91841000.329Contact Map0.756
2oljA20.69681000.33Contact Map0.82

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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