GREMLIN.BAKERLAB.org
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BASR - Transcriptional regulatory protein BasR
UniProt: P30843 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11615
Length: 222 (217)
Sequences: 31205
Seq/Len: 143.80

BASR
Paralog alert: 0.93 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
13_L 29_S 3.567 1.00
13_L 31_T 2.882 1.00
17_I 29_S 2.636 1.00
34_R 56_D 2.523 1.00
32_T 56_D 2.436 1.00
28_D 45_Y 2.435 1.00
6_V 36_A 2.428 1.00
33_A 57_E 2.284 1.00
57_E 65_R 2.271 1.00
153_K 156_A 2.212 1.00
154_E 200_K 2.196 1.00
17_I 21_Q 2.182 1.00
188_N 191_E 2.173 1.00
32_T 35_M 2.145 1.00
171_R 191_E 2.114 1.00
37_E 65_R 2.081 1.00
84_L 104_A 2.073 1.00
58_D 61_H 2.038 1.00
41_E 69_K 2.037 1.00
19_A 105_L 1.994 1.00
2_K 26_A 1.952 1.00
31_T 35_M 1.901 1.00
87_K 107_E 1.868 1.00
207_R 217_V 1.795 1.00
131_N 144_G 1.778 1.00
4_L 30_V 1.776 1.00
30_V 39_S 1.768 1.00
159_S 163_L 1.745 1.00
50_L 62_F 1.741 1.00
2_K 28_D 1.731 1.00
207_R 215_M 1.73 1.00
47_L 112_I 1.689 1.00
128_I 133_T 1.686 1.00
140_Q 147_E 1.672 1.00
77_I 90_G 1.653 1.00
20_A 112_I 1.648 1.00
53_G 81_R 1.645 1.00
63_L 75_V 1.637 1.00
65_R 68_Q 1.625 1.00
133_T 142_W 1.611 1.00
28_D 39_S 1.579 1.00
193_H 196_N 1.573 1.00
50_L 63_L 1.572 1.00
92_D 113_R 1.562 1.00
96_D 118_R 1.548 1.00
76_L 115_L 1.545 1.00
134_L 162_M 1.538 1.00
23_E 109_H 1.529 1.00
6_V 54_L 1.501 1.00
63_L 77_I 1.49 1.00
52_L 77_I 1.489 1.00
170_H 173_I 1.465 1.00
164_K 167_S 1.445 1.00
57_E 61_H 1.441 1.00
48_V 73_L 1.44 1.00
33_A 62_F 1.431 1.00
160_R 177_D 1.412 1.00
65_R 69_K 1.411 1.00
37_E 62_F 1.408 1.00
160_R 174_L 1.398 0.99
81_R 86_D 1.37 0.99
7_E 13_L 1.366 0.99
77_I 95_A 1.358 0.99
169_V 177_D 1.332 0.99
61_H 64_A 1.322 0.99
28_D 43_G 1.322 0.99
25_Y 113_R 1.319 0.99
38_Q 42_A 1.31 0.99
39_S 43_G 1.299 0.99
67_R 96_D 1.296 0.99
194_I 198_R 1.278 0.99
64_A 93_V 1.265 0.99
39_S 42_A 1.254 0.99
60_L 93_V 1.23 0.98
3_I 25_Y 1.22 0.98
30_V 36_A 1.219 0.98
34_R 38_Q 1.214 0.98
52_L 60_L 1.213 0.98
34_R 57_E 1.208 0.98
40_L 66_I 1.204 0.98
135_N 138_R 1.202 0.98
165_A 169_V 1.193 0.98
37_E 57_E 1.19 0.98
47_L 116_L 1.187 0.98
209_V 215_M 1.182 0.98
97_D 111_R 1.179 0.98
64_A 89_A 1.15 0.97
10_T 31_T 1.133 0.97
8_D 51_D 1.122 0.97
83_T 86_D 1.115 0.96
139_R 212_F 1.114 0.96
35_M 38_Q 1.108 0.96
84_L 88_I 1.1 0.96
160_R 169_V 1.079 0.95
24_G 113_R 1.078 0.95
60_L 89_A 1.077 0.95
35_M 39_S 1.074 0.95
70_K 73_L 1.067 0.95
189_T 193_H 1.064 0.95
6_V 48_V 1.062 0.95
39_S 45_Y 1.06 0.95
16_L 78_L 1.059 0.95
136_M 159_S 1.04 0.94
139_R 156_A 1.037 0.94
167_S 173_I 1.037 0.94
85_T 89_A 1.032 0.94
5_I 27_C 1.03 0.94
4_L 45_Y 1.029 0.94
4_L 36_A 1.029 0.94
126_E 133_T 1.025 0.93
151_T 200_K 1.024 0.93
89_A 93_V 1.02 0.93
60_L 90_G 1.015 0.93
172_E 187_T 1.014 0.93
48_V 66_I 1.011 0.93
36_A 40_L 1.006 0.93
134_L 155_Y 1.001 0.92
172_E 176_N 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gwrA10.99551000.14Contact Map0.696
3r0jA20.9911000.143Contact Map0.676
1ys7A20.98651000.149Contact Map0.791
1kgsA10.98651000.171Contact Map0.718
2oqrA10.97751000.172Contact Map0.57
4b09A120.99551000.183Contact Map0.671
2hqrA20.96851000.185Contact Map0.691
1p2fA10.95951000.202Contact Map0.748
3q9sA10.93691000.22Contact Map0.696
3c3wA20.94591000.279Contact Map0.627

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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