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BAES - Signal transduction histidine-protein kinase BaeS
UniProt: P30847 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11617
Length: 467 (456)
Sequences: 3173
Seq/Len: 6.96

BAES
Paralog alert: 0.75 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
392_D 396_G 4.271 1.00
391_A 452_S 4.05 1.00
443_A 453_I 4.047 1.00
357_L 433_I 3.844 1.00
439_G 457_L 3.593 1.00
369_T 393_S 3.547 1.00
263_L 281_L 3.541 1.00
430_C 441_I 3.521 1.00
369_T 373_G 3.468 1.00
260_R 286_G 3.236 1.00
406_F 441_I 3.231 1.00
431_L 435_E 3.202 1.00
434_V 439_G 3.18 1.00
111_D 115_K 3.083 1.00
243_D 247_D 2.917 1.00
434_V 455_V 2.813 1.00
349_G 354_L 2.805 1.00
216_S 221_G 2.757 1.00
402_L 445_H 2.746 1.00
445_H 451_V 2.741 1.00
446_S 449_G 2.674 1.00
385_T 456_E 2.529 1.00
357_L 434_V 2.528 1.00
349_G 437_H 2.492 1.00
378_S 391_A 2.486 1.00
211_R 235_E 2.447 1.00
357_L 455_V 2.398 1.00
392_D 450_G 2.396 1.00
322_A 362_L 2.369 1.00
202_K 207_D 2.326 1.00
330_F 366_L 2.311 1.00
340_S 378_S 2.294 1.00
218_D 221_G 2.287 1.00
404_K 407_E 2.275 1.00
319_L 358_F 2.251 1.00
313_V 349_G 2.223 1.00
376_Q 391_A 2.179 1.00
368_Y 411_R 2.151 1.00
314_D 344_S 2.146 1.00
311_A 351_R 2.133 1.00
433_I 437_H 2.123 1.00
389_T 452_S 2.102 1.00
443_A 451_V 2.078 1.00
405_L 443_A 2.042 1.00
418_R 421_G 2.038 1.00
442_I 454_T 2.006 1.00
363_E 367_R 2 1.00
398_S 401_Q 1.975 1.00
319_L 388_L 1.971 1.00
440_R 456_E 1.965 1.00
358_F 388_L 1.926 1.00
439_G 458_P 1.894 1.00
378_S 389_T 1.856 1.00
444_A 454_T 1.815 1.00
211_R 231_A 1.812 1.00
389_T 454_T 1.805 1.00
312_P 348_F 1.799 1.00
445_H 448_F 1.796 1.00
244_F 248_I 1.765 1.00
406_F 453_I 1.756 1.00
444_A 452_S 1.756 1.00
402_L 443_A 1.743 1.00
353_R 356_Q 1.741 1.00
445_H 449_G 1.733 1.00
398_S 412_T 1.732 1.00
413_E 416_R 1.729 1.00
209_T 235_E 1.721 1.00
338_Q 376_Q 1.711 1.00
406_F 443_A 1.711 1.00
193_V 220_L 1.701 1.00
227_F 230_L 1.688 1.00
373_G 393_S 1.654 1.00
397_V 405_L 1.648 1.00
434_V 457_L 1.645 1.00
340_S 376_Q 1.626 1.00
203_L 230_L 1.62 1.00
382_R 387_R 1.62 1.00
434_V 441_I 1.615 1.00
211_R 232_S 1.606 1.00
260_R 289_T 1.604 1.00
323_G 377_I 1.601 1.00
336_K 374_S 1.587 1.00
241_R 245_M 1.584 1.00
244_F 296_H 1.583 1.00
380_G 389_T 1.583 1.00
386_V 459_L 1.57 1.00
315_L 386_V 1.565 1.00
401_Q 410_Y 1.564 1.00
387_R 456_E 1.548 0.99
353_R 436_A 1.542 0.99
314_D 317_P 1.54 0.99
330_F 375_L 1.54 0.99
388_L 455_V 1.524 0.99
263_L 278_V 1.516 0.99
425_L 429_I 1.508 0.99
401_Q 412_T 1.501 0.99
338_Q 374_S 1.501 0.99
361_L 453_I 1.492 0.99
381_Q 459_L 1.489 0.99
312_P 346_T 1.477 0.99
353_R 433_I 1.477 0.99
401_Q 404_K 1.475 0.99
196_L 224_A 1.463 0.99
203_L 231_A 1.452 0.99
9_T 187_R 1.443 0.99
247_D 408_R 1.442 0.99
374_S 393_S 1.434 0.99
290_K 352_D 1.431 0.99
397_V 451_V 1.429 0.99
362_L 390_F 1.415 0.99
382_R 456_E 1.41 0.99
358_F 390_F 1.372 0.98
238_Q 241_R 1.362 0.98
368_Y 395_P 1.361 0.98
360_N 430_C 1.358 0.98
397_V 402_L 1.346 0.98
321_V 351_R 1.345 0.98
347_V 386_V 1.336 0.98
263_L 285_V 1.327 0.98
376_Q 393_S 1.327 0.98
259_L 281_L 1.325 0.98
357_L 430_C 1.307 0.98
397_V 445_H 1.302 0.98
263_L 282_Q 1.301 0.98
196_L 227_F 1.282 0.97
396_G 450_G 1.281 0.97
395_P 451_V 1.279 0.97
361_L 455_V 1.274 0.97
289_T 293_D 1.272 0.97
267_Q 282_Q 1.269 0.97
182_T 186_A 1.261 0.97
392_D 451_V 1.261 0.97
296_H 423_S 1.238 0.97
345_I 379_A 1.233 0.96
249_S 296_H 1.228 0.96
353_R 357_L 1.222 0.96
361_L 390_F 1.209 0.96
313_V 354_L 1.202 0.96
211_R 228_N 1.201 0.96
176_L 180_L 1.193 0.96
326_F 359_N 1.19 0.95
244_F 249_S 1.188 0.95
260_R 282_Q 1.187 0.95
380_G 387_R 1.175 0.95
387_R 454_T 1.175 0.95
394_A 397_V 1.173 0.95
319_L 390_F 1.17 0.95
296_H 300_M 1.165 0.95
370_D 393_S 1.165 0.95
340_S 380_G 1.163 0.95
262_E 280_S 1.158 0.94
401_Q 405_L 1.158 0.94
194_K 197_V 1.146 0.94
253_R 293_D 1.142 0.94
396_G 451_V 1.142 0.94
337_L 377_I 1.128 0.93
230_L 234_L 1.127 0.93
430_C 434_V 1.123 0.93
244_F 251_E 1.114 0.93
13_F 17_F 1.113 0.93
281_L 285_V 1.112 0.93
260_R 285_V 1.112 0.93
197_V 222_K 1.109 0.93
354_L 437_H 1.102 0.92
441_I 453_I 1.097 0.92
200_T 226_D 1.093 0.92
284_E 287_T 1.087 0.92
318_L 349_G 1.084 0.92
194_K 198_D 1.082 0.91
325_A 355_M 1.079 0.91
7_G 10_G 1.078 0.91
266_I 278_V 1.077 0.91
387_R 442_I 1.074 0.91
397_V 403_Q 1.073 0.91
330_F 335_L 1.069 0.91
264_E 282_Q 1.067 0.91
330_F 337_L 1.066 0.91
375_L 390_F 1.064 0.91
208_F 211_R 1.058 0.90
363_E 408_R 1.055 0.90
239_Q 243_D 1.054 0.90
442_I 456_E 1.052 0.90
399_D 402_L 1.051 0.90
235_E 239_Q 1.05 0.90
244_F 409_F 1.049 0.90
405_L 453_I 1.045 0.89
251_E 356_Q 1.045 0.89
358_F 362_L 1.04 0.89
11_K 218_D 1.04 0.89
408_R 429_I 1.037 0.89
404_K 410_Y 1.037 0.89
335_L 375_L 1.028 0.88
259_L 285_V 1.027 0.88
314_D 346_T 1.023 0.88
200_T 227_F 1.019 0.88
258_V 261_G 1.019 0.88
370_D 373_G 1.011 0.87
310_K 348_F 1.011 0.87
245_M 298_L 1.01 0.87
260_R 264_E 1.008 0.87
315_L 388_L 1.007 0.87
345_I 386_V 1.006 0.87
200_T 230_L 1.005 0.87
310_K 437_H 1.002 0.87
319_L 379_A 1.001 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.67021000.433Contact Map0.794
2btzA10.67021000.537Contact Map0.571
4ew8A20.55461000.546Contact Map0.781
3jz3A20.4691000.554Contact Map0.672
2q8gA10.69161000.554Contact Map0.574
2e0aA20.68091000.555Contact Map0.612
4e01A10.70241000.556Contact Map0.611
2c2aA10.52681000.563Contact Map0.734
1y8oA10.71521000.565Contact Map0.595
3d36A20.49251000.581Contact Map0.721

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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