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ARTI - Putative ABC transporter arginine-binding protein 2
UniProt: P30859 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11625
Length: 243 (224)
Sequences: 10389
Seq/Len: 46.38

ARTI
Paralog alert: 0.90 [within 20: 0.42] - ratio of genomes with paralogs
Cluster includes: ARGT ARTI ARTJ FLIY GLNH GLTI HISJ YHDW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
130_G 168_I 3.788 1.00
26_A 81_V 3.489 1.00
22_T 63_T 3.364 1.00
57_E 226_K 3.187 1.00
102_T 225_E 2.58 1.00
153_Y 162_D 2.492 1.00
24_R 63_T 2.435 1.00
92_P 95_E 2.388 1.00
90_I 206_G 2.387 1.00
232_T 235_T 2.365 1.00
90_I 95_E 2.322 1.00
217_Q 221_N 2.239 1.00
234_E 238_N 2.221 1.00
22_T 61_T 2.18 1.00
75_S 81_V 2.178 1.00
24_R 65_S 2.175 1.00
98_V 208_A 2.093 1.00
55_C 62_C 2.083 1.00
225_E 229_K 2.026 1.00
120_S 123_Q 2.021 1.00
53_A 56_K 2.021 1.00
138_Q 152_P 2.014 1.00
155_S 158_N 2.011 1.00
138_Q 142_M 1.983 1.00
38_D 44_V 1.953 1.00
209_V 220_L 1.918 1.00
209_V 217_Q 1.916 1.00
77_K 97_Q 1.912 1.00
53_A 232_T 1.909 1.00
128_K 151_V 1.904 1.00
102_T 221_N 1.842 1.00
99_L 217_Q 1.83 1.00
128_K 149_T 1.819 1.00
173_G 178_V 1.772 1.00
210_R 213_N 1.766 1.00
49_D 239_K 1.764 1.00
57_E 223_A 1.739 1.00
53_A 57_E 1.724 1.00
53_A 227_V 1.684 1.00
101_T 221_N 1.664 1.00
214_T 218_Q 1.636 1.00
85_M 207_I 1.629 1.00
38_D 42_Q 1.605 1.00
112_V 178_V 1.602 1.00
218_Q 222_T 1.596 1.00
57_E 230_D 1.587 1.00
49_D 240_W 1.58 1.00
99_L 212_G 1.568 1.00
159_A 171_V 1.564 1.00
25_F 51_A 1.475 1.00
75_S 80_R 1.45 1.00
127_K 169_D 1.448 1.00
25_F 83_A 1.426 1.00
114_Q 117_K 1.404 0.99
129_V 170_G 1.378 0.99
114_Q 166_G 1.377 0.99
133_N 154_D 1.369 0.99
115_Q 189_A 1.351 0.99
162_D 167_R 1.347 0.99
93_E 96_K 1.342 0.99
154_D 158_N 1.324 0.99
163_L 168_I 1.317 0.99
36_S 44_V 1.314 0.99
58_I 223_A 1.303 0.99
52_Q 64_F 1.301 0.99
219_K 222_T 1.298 0.99
47_D 104_Y 1.293 0.99
175_T 179_T 1.292 0.99
99_L 214_T 1.29 0.99
116_G 189_A 1.288 0.99
67_Q 75_S 1.287 0.99
79_R 210_R 1.272 0.99
101_T 220_L 1.269 0.99
84_V 88_M 1.266 0.99
222_T 226_K 1.263 0.99
72_L 84_V 1.261 0.99
111_F 170_G 1.26 0.99
106_D 204_G 1.255 0.99
54_L 223_A 1.245 0.98
219_K 223_A 1.24 0.98
232_T 236_I 1.234 0.98
73_I 98_V 1.234 0.98
139_K 143_D 1.217 0.98
130_G 153_Y 1.21 0.98
46_F 236_I 1.203 0.98
132_Q 135_T 1.198 0.98
46_F 237_Y 1.184 0.98
128_K 169_D 1.183 0.98
83_A 220_L 1.179 0.98
140_F 144_K 1.173 0.98
83_A 209_V 1.173 0.98
163_L 171_V 1.164 0.97
162_D 168_I 1.152 0.97
68_A 71_S 1.151 0.97
226_K 230_D 1.15 0.97
88_M 208_A 1.148 0.97
42_Q 52_Q 1.148 0.97
223_A 226_K 1.139 0.97
37_I 66_N 1.124 0.97
113_G 191_V 1.112 0.96
50_L 227_V 1.111 0.96
46_F 241_F 1.111 0.96
228_K 233_Y 1.105 0.96
153_Y 159_A 1.104 0.96
130_G 159_A 1.104 0.96
122_D 125_K 1.102 0.96
223_A 227_V 1.1 0.96
48_V 52_Q 1.096 0.96
25_F 62_C 1.089 0.96
108_S 175_T 1.087 0.96
142_M 152_P 1.086 0.96
110_L 175_T 1.082 0.96
49_D 52_Q 1.069 0.95
57_E 227_V 1.065 0.95
52_Q 56_K 1.061 0.95
163_L 188_L 1.056 0.95
99_L 211_Q 1.054 0.95
110_L 190_A 1.052 0.95
91_T 94_R 1.052 0.95
50_L 233_Y 1.049 0.94
51_A 85_M 1.028 0.94
161_L 165_N 1.026 0.94
74_P 77_K 1.022 0.93
51_A 64_F 1.02 0.93
43_I 48_V 1.019 0.93
125_K 147_E 1.014 0.93
34_F 105_Y 1.013 0.93
76_L 84_V 1.009 0.93
67_Q 81_V 1.009 0.93
227_V 232_T 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2yjpA30.98351000.205Contact Map0.85
1xt8A20.98351000.215Contact Map0.863
2y7iA20.93831000.215Contact Map0.802
2ylnA10.97121000.225Contact Map0.822
3kzgA40.90951000.234Contact Map0.88
4kqpA10.92591000.235Contact Map0.799
3h7mA10.931000.236Contact Map0.795
3hv1A20.97941000.236Contact Map0.8
1lstA10.931000.237Contact Map0.831
3i6vA10.8931000.238Contact Map0.805

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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